LACTATIONAL EXPOSURE TO DI-2-ETHYL HEXYL PHTHALATE (DEHP) INDUCES OXIDATIVE STRESS AND CAUSES NEURODEGENERATION IN HIPPOCAMPUS OF OFFSPRING FEMALE ALBINO RATS
Keywords:Phthalates, Lipid peroxidation, Superoxide dismutase, estrogen receptor, Bcl-2, Nissl’s granules
The purpose of this study was to determine the effect of DEHP on the hippocampus of F1 progeny female albino rats. Healthy mother rats were divided into four groups. The first group (control) was orally fed with olive oil–vehicle and the other three groups were treated with DEHP 1, 10 and 100 mg /kg bw/day via oral gavage from PND (Post natal day) 1 till 21. On PND 60 the offspring female rats were sacrificed, their hippocampus dissected and processed for biochemical analysis. Results showed that DEHP induced oxidative stress in hippocampus by increasing reactive oxygen species and decreasing antioxidant enzymes. Further, DEHP reduced the mRNA expression of ER?, ? and decreased that of Bcl2. Construction of a protein-protein interaction map with ER?, ?, Bcl2 and their downstream interacting partners confirmed the existence of a network, enriched for molecular functions. To conclude, lactational exposure to DEHP causes hippocampal neurotoxicity.
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