INTERPLAY OF SOLUBILITY AND DISSOLUTION IN DOSAGE FORM DEVELOPEMNT
Keywords:BCS, IVIVC, Solubility, theory of dissolution, Bioavailability
For the drug formulation and drug delivery, poor solubility and the dissolution of drugs are the major challenges. The drugs which have a water solubility less than 10 mg/ml (over the pH range of 1 to 7 at 37 ºC) show potential bioavailability problems. The bioavailability of the drugs (which show the solubility or dissolution rate-limited absorption) may be improved by improving their aqueous solubility. Moreover, the various formulations need water solubility of the drug as a prerequisite. The article discussed the basic concept related to solubility and dissolution, their importance in biopharmaceutical classification of drugs along their significance in pharmaceutical drug delivery.
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