INTERPLAY OF SOLUBILITY AND DISSOLUTION IN DOSAGE FORM DEVELOPEMNT

Abstract

For the drug formulation and drug delivery, poor solubility and the dissolution of drugs are the major challenges. The drugs which have a water solubility less than 10 mg/ml (over the pH range of 1 to 7 at 37 ºC) show potential bioavailability problems. The bioavailability of the drugs (which show the solubility or dissolution rate-limited absorption) may be improved by improving their aqueous solubility. Moreover, the various formulations need water solubility of the drug as a prerequisite. The article discussed the basic concept related to solubility and dissolution, their importance in biopharmaceutical classification of drugs along their significance in pharmaceutical drug delivery.