INTERPLAY OF SOLUBILITY AND DISSOLUTION IN DOSAGE FORM DEVELOPEMNT

Authors

  • Dr. Ajay Semalty Faculty of Pharmacy, Department of Pharmaceutical Sciences, H.N.B Garhwal (Central) University, Srinagar (Garhwal)-Uttarakhand, INDIA

Keywords:

BCS, IVIVC, Solubility, theory of dissolution, Bioavailability

Abstract

For the drug formulation and drug delivery, poor solubility and the dissolution of drugs are the major challenges. The drugs which have a water solubility less than 10 mg/ml (over the pH range of 1 to 7 at 37 ºC) show potential bioavailability problems. The bioavailability of the drugs (which show the solubility or dissolution rate-limited absorption) may be improved by improving their aqueous solubility. Moreover, the various formulations need water solubility of the drug as a prerequisite. The article discussed the basic concept related to solubility and dissolution, their importance in biopharmaceutical classification of drugs along their significance in pharmaceutical drug delivery.

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Published

2014-01-11
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13 Views | 8 Downloads
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How to Cite

Dr. Ajay Semalty. “INTERPLAY OF SOLUBILITY AND DISSOLUTION IN DOSAGE FORM DEVELOPEMNT”. International Journal of Pharmaceutics and Drug Analysis, vol. 2, no. 1, Jan. 2014, pp. 13-24, https://ijpda.com/index.php/journal/article/view/8.

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Section

Review Articles
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