EXPLORATION OF NOVEL CO-PROCESSED MULTIFUNCTIONAL EXCIPIENT FOR TABLET DOSAGE FORM
Keywords:Co-processed excipients (CPE), direct compression, superdisintegrants
The aim of the present investigation is to formulate novel co-processed multifunctional excipient for tablet dosage form.Co- processed particles of chitosan, microcrystalline cellulose (MCC) and aerosil-200 were fabricated by wet granulation technique to be used as a directly compressible excipient in tablet formulation. The developed co-processed excipients (CPE) were evaluated for their excipient related and dosage form related parameters. As expected, all the prepared batches exhibited acceptable angle of repose (<350) and quick disintegration time (<1min). The “intimate” physical association between chitosan, MCC and aerosil-200 has created an insoluble, hydrophilic, highly absorbent material, resulting in superiority in water uptake, water saturation for gelling formation, and compactability among other superdisintegrants. The developed CPE could be act as a superdisintegrant and pharmaceutical filler at the same time.
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