STUDY OF SOME 1,2,4-TRIAZOLES DERIVATIVES AND THEIR BIOLOGICAL ACTIVITIES

Authors

  • Mohammad Asif Department of Pharmacy, GRD(PG)IMT, Dehradun, (UK), 248009, India

Keywords:

Antimicrobial, heterocyclic, triazole, pharmacological properties.

Abstract

It is well established that various derivatives of triazole exhibit broad spectrum of pharmacological properties. The 1,2,4-triazole moiety present in the various natural products and the synthesis of compounds. This moiety has attracted attention of chemists as well as biologists. The compounds containing different heterocyclic moiety would be tested for antimicrobial activity against different strains of pathogenic organisms. Similarly few of the compounds would also be screened for anti-inflammatory and analgesic activities.

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References

Asami T, Min YK, Nagata N, Amagishi KY, Takatsuto S, Fujioka S, Murofushi N, Yamaguchi I, Yoshida S, characterization of brassinazole, a triazole-type brassinosteroid biosynthesis inhibitor. Plant physiol, 2000, 123(1), 93-100.

Ram VJ, Mishra L, Pandey NH, Kushwaha DH, Pieters LAC, Vlietinck AJ, Bis heterocycles as potential chemotherapeutic agents. X. synthesis of Bis(4-aryl thiosemicabazido-)bis(2-aryl amino 1,3,4 thiadiazole-5yl) and bis(4-aryl-1,2,4-triazolin-3-thion-5yl) pentenes and related compounds, J. heterocycl, chem.1990,27,351.

Upadhyay PS, Vansdadia RN, Baxi AJ, studies on sulphone derivative: preparation and antimicrobial activity of thiosemicarbazides, thiazolidones, triazoles, oxadiazoles, and thiadiazole, Indian J chem, Sec B, 1990, 29,793.

Reddy KR, Mogilaiah K, Swamy D. Synthesis of some 1,8-naphthyridinyl thiosemicarbazides, triazoles and thiadiazole. Acta Chim Hung, 1990, 127, 45.

Kucukguzel I, Kucukguzel SG, Rollas S, Kiraz M. Some 3-thioxo/alkylthio-1,2,4-triazoles with a substituted thiourea moiety as possible antimycobacterials. Bioorg Med Chem Lett, 2001, 11, 1703-1707.

Kritsanida M, Mouroutsou A, Marakos P, Pouli N, Papakonstantinou S, Pannecouque C, Witvouw M, De Clercq E. Synthesis and antiviral activity evaluation of some new 6-substituted 3-(1-adamantyl)-1,2,4-triazolo-[3,4-b][1,3,4]thiadiazoles, Il Farmaco, 2002, 57, 253-257.

Mathew V, Keshavayya J, Vaidya VP, Giles D. Studies on synthesis and pharmacological activities of 3,6-disubstituted-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles and their dihydro analogues. Eur J Med Chem, 2007,42, 823-840.

Tozkoparan B,Kupeli E. Yesilada E,Ertan M, Preparation of 5-aryl-3 alkylthio 1,2,4-triazoles and corresponding sulfones with anti-inflammatory, analgesic activity, Bioorg. Med. Chem.2007, 15 ,1808-1814.

Langley M.S, Clissold S.P, in: Adis International (Ed.), Brotizolam: a Review of Its Pharmacodynamic and Pharmacokinetic Properties, and Therapeutic Efficacy as an Hypnotic. Drugs, 1988, 104-122.

Przegalinski E,Lewandowska A. The effect of etoperidone, a new potential antidepressant drug, on the central serotonin system. Journal. Neural Transm. 1979, 46, 303-312.

Kucukguzel I, Kucukguzel SG, Rollas S, Kiraz M. Some 3-thioxo/alkylthio-1,2,4-triazoles with a substituted thiourea moiety as possible antimycobacterials. Bioorg Med Chem Lett, 2001, 11, 1703-1707.

Demirbas N, Ugurluoglu R, Demirbas A. Synthesis of 3-alkyl(aryl)-4- alkylidenamino-4,5-dihydro-1H-1,2,4-triazol-5-ones and 3-alkyl-4-alkylamino-4,5- dihydro-1H-1,2,4-triazol-5-ones as antitumor agents. Bioorg Med Chem, 2002, 10, 3717-3723.

Turan-Zitouni G,Kaplancikli Z A, Erol K, Killic F S. Synthesis and analgesic activity of some triazoles and triazolothiadiazines. Il Farmaco, 1999, 54, 218-223.

Ghannoum M, Rice LB. Antifungal agents: mode of action, mechanism of resistance, and correlation of these mechanisms with bacterial resistance. Clin Microbiol Rev, 1999, 12, 501-517.

Mhasalkar MY, Shah MH, Nikam ST. Further studies in substituted 4H-1,2,4-triazoles for possible hypoglycemic activity. J Med Chem, 1971, 14(3), 260-262.

Delgado JN, Remers WA. Text Book of Organic, Medicinal and Pharmaceutical Chemistry, tenth ed. J.B., Lippincott Company, Philadelphia, 1998, 189.

Witkop B, Ramachandran LK, Progress in non-enzymatic selective modification and cleavage of proteins. Metabolism, 1964, 13(10), 1016-1025.

Rao G, Rajasekaran S, Attimarad M. Synthesis and antimicrobial activityof some 5-phenyl-4-substituted amino-3-mercapto (4H)-1,2,4-triazoles. Indian J Pharm Sci, 2000, 62(6), 475-477.

Kane JM, Baron BM, Dudley MW, Sorensen SM, Staeger MA, Miller FP. 2,4-Dihydro-3H-1,2,4-triazol-3-ones as anticonvulsant agents. J Med Chem, 1990, 33(10), 2772-2777.

Clereq D. In search of a selective antiviral chemotherapy. Clin Microbial Rev, 1997, 10, 674-93.

Alterman M, Samuelsson B. Design and synthesis of new potent C2-symmetric HIV-1 protease inhibitors. Use of L-mannaric acid as a peptidomimetic scaffold. J Med Chem, 1998,41, 3782-92.

Khalil SA. Efficient synthesis of novel 1,2,4-triazole fused acyclic and 21-28 membered macrocyclic with potent antimicrobial activity. Eur J Med Chem, 2010, 45, 5265-5277.

Manicrao AM. Accelerated synthesis 3-(N-substituted carboxamidomethylthio)-(4H)-1,2,4-triazoles under microwave irradiation. Inter J Chem Tech Res, 2009, 1(4), 1268-1272.

Somani RR. synthesis of some antifungal and anti-tubercular 1,2,4-triazole analogues. Inter J Chem Tech Res, 2009, 1(2),168-173.

Neslihan D. Synthesis of some new 1,2,4-triazoles, their Mannich and Schiff bases and evaluation for their antimicrobial activities. Eur J Med Chem, 2009, 44,1057-1066.

Neslihan D, Synthesis and antimicrobial activities of some new 1,2,4-triazoles derivatives. Molecules, 2010,15, 2427-2438.

Jianzin F Synthesis and biological activities of new 1H-1,2,4-triazoles derivatives containing ferrocenyl moiety. J Organometalic Chem, 2006, 691, 2686-2690.

Erhan P. Synthesis of 1-acylthiosemicarbazides, 1,3,4-oxadiazoles, 1,3,4-thiadiazole and 1,2,4-triazoles-3-thiones. Farmaco, 2007, 57, 101-107.

Neslihan D. Synthesis of some new 1,2,4-triazoles starting from isonicotinic acid hydrazide and evaluation for their antimicrobial activities. Eur J Med Chem, 2009, 44,4362-4366.

Birsen T. preparation of 5-aryl-3-alkylthio-1,2,4-triazolesand corresponding sulfones with anti-inflammatory-analgesic activity. Bioorg and Med Chem, 2007, 15, 1808-1814.

Nesrin GK. 1-Acylthiosemicarbazides,1,2,4-triazole-5(4H)-thiones, 1,3,4-thiadiazole with analgesic, anti-inflammatory and antimicrobial activities. Bioorg and Med Chem, 2007, 15, 5738-5751.

Goyal PK. Synthesis, characterization of some new 1,2,4-triazoles with their analgesic activity. Inter J Chem Tech, 2010, 2(4), 1992-1997.

Published

2014-04-23
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Mohammad Asif. “STUDY OF SOME 1,2,4-TRIAZOLES DERIVATIVES AND THEIR BIOLOGICAL ACTIVITIES”. International Journal of Pharmaceutics and Drug Analysis, vol. 2, no. 4, Apr. 2014, pp. 325-8, https://ijpda.com/index.php/journal/article/view/58.

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