Microemulsions: a promising drug delivery system
Keywords:Co-surfactants, Microemulsion, Surfactants, Thermodynamically stable
Microemulsions, comprising oil, water and a surfactant, in association with some co-surfactant, are thermodynamically stable systems. They have found applications in a large number of chemical and pharmacological processes due to their unique properties such as large interfacial area, low interfacial tension, and most importantly, the ability to solubilize and deliver hydrophobic drugs. Microemulsions are ore, topical and parenteral administration. Microemulsions are thermodynamically stable. Microemulsions are clear, thermodynamically stable isotropic liquid mixtures of oil, water and surfactant, frequently in combination with a cosurfactant. This review highlights the properties and several recent developments in the use of microemulsions for medical treatment purposes including targeted drug delivery.
Shah Rohit Ramesh, Magdum Chandrakant Shripal; Preparation and Evaluation of Aceclofenac Topical Microemulsion; Iranian Journal of Pharmaceutical Research., 9(1) (2010) 5-11.
Sharma Pankaj Kumar; Enhancement of solubility and stability of Celecoxib using microemulsion based topical formulation; Journal of Pharmacy Research., 4(7) (2011) 2216-2220.
Jadhav K. R, Shetye S. L, Kadam V. J; Design and Evaluation of Microemulsion Based Drug Delivery System; International Journal of Advances in Pharmaceutical Sciences., 1 (2010) 156-166.
Fathy I. Abdallah, Hamdy M. Dawaba; Evaluation of the anti-inflammatory and analgesic effects of piroxicamloadedmicroemulsion in topical formulations; Int J Pharm Pharm Sci., 3(2)(2011) 6670
Shishu, Rajan Sunita and Kamalpreet; Development of Novel Microemulsion-Based Topical Formulations of Acyclovir for the Treatment of Cutaneous Herpetic Infections; AAPS PharmSciTech., 10 (2009) 559-565.
Ikechukwu UR, John Francis DE, Ambi AA. Development and evaluation of Ritonavir hollow microballoons for floating drug delivery. Universal Journal of Pharmaceutical Research 2017; 2(2): 8-11.
Angela Attar Nasseri, Reza Aboofazeli, Hossein Zia, Thomas E Needham; Lecithin Stabilized Microemulsion – Based Organogels for Topical Application of Ketorolac Tromethamine. II. In vitro Release Study; Iranian Journal of Pharmaceutical Research; (2003) 117-123.
Mrunali R. Patel, Rashmin B. Patel, Jolly R. Parikh; Effect of Formulation Components on the In Vitro Permeation of Microemulsion Drug Delivery System of Fluconazole; AAPS PharmSciTech.,10 (2009) 917-923.
Yusuf FS. Formulation and in-vitro evaluation of floating microballoons of stavudine. Universal Journal of Pharmaceutical Research 2016; 1(1): 8-11.
Susijit Sahoo, Bhakti Bhusan Barik, Nihar Ranjan Pani; Formulation and characterization of microemulsion of an anti-fungal drug; Journal of Pharmacy Research., 4(7) (2011) 2397-2399.
Nadeem Abbas Kizilbash, Dhaifallah Alenizi; Design of a Microemulsion-Based Drug Delivery System for Diclofenac Sodium; J.Chem.Soc.Pak., 33 (20110, 1-6.
Yuan Y, Li S-M, Mo F-K, D-F Zhong: Investigation of microemulsion system for transdermal delivery of meloxicam. Int J Pharm 2006; 321: 117-123.
Hellweg T, Phase structure of microemulsions, Curr opin colloid interface sci.,7, (2002) 50-56.
Kumar. K. Senthil, Dhachinamoorthi. D, Saravanan. R; Microemulsions as Carrier for Novel Drug Delivery: A Review; International Journal of Pharmaceutical Sciences Review and Research., 10 (2011) 37-45.
Chauhan N, Kumar K, Pant NC. An updated review on transfersomes: a novel vesicular system for transdermal drug delivery. Universal Journal of Pharmaceutical Research 2017; 2(4): 42-45.
Hunter, R. J: Introduction to Modern Colloid Science; 1st ed.; Oxford University Press: Oxford, 1994.
Sushama Talegaonkar, Adnan Azeem, Farhan Ahmad J, Roop Khar K, Shadab Pathan A, Zeenat Khan I; Microemulsions:A Novel approach to enhanced drug delivery; Recent patents on drug delivery and formulation; 2, 2008; 238-257.
Shafiq un Nabi S, Shakeel F, Talegaonkar S; Formulation development and optimization using nanoemulsion technique: A technical note; AAPS Pharm Sci Tech., 8 (2007) 1-6.
ALGIN YAPAR E, BESKAN U, KARAVANA SY. A recent overview of locally administered topical otic dosage forms. Universal Journal of Pharmaceutical Research 2019; 4(4): 39-42.
Hsiu-O Ho, Chih-Chuan Hsiao, Ming-Thau Sheu, preparation of microemulsions using polyglycerol fatty acid esters as surfactant for the delivery of protein drugs. J. pharm. Sci. 1996; 58: 138-143.
Dreher F, Walde P, Walther P, Wehrli E, Interaction of a lecithin microemulsion gel with human stratum corneum and its effect on transdermal transport. J. Control. Rel.1997; 45:131-140.
Agarwal P, Semimul A. A comprehensive review on sustained release matrix tablets: a promising dosage form. Universal Journal of Pharmaceutical Research 2018; 3(6): 49-54.
Ashok Patel R, Pradeep vavia R; Preparation and Invivo Evaluation of Self-Microemulsifying Drug Delivery System Containing fenofibrate; The AAPS Journal., 9 (2007) 344-352.
Peltola S, Saarinen S P, Kiesavaara J ,Urttia S T M; Microemulsions for topical delivery of estradiol; Int J Pharm., 254 (2003) 99-107.
Alfisha Saifi, Kapil Kumar, Deepak Teotia. A basic review on micro emulsion as a drug delivery system. Journal of Biomedical and Pharmaceutical Research. Volume 9, Issue 5: September-October: 2020, 06-11.
Rahi N, Kumar K. Nanosponges: a new era of versatile drug delivery system. Universal Journal of
Pharmaceutical Research 2017; 2(3): 30-33.
2Gurleen Kaur, Alfisha Saifi, Kapil Kumar , Deepak Teotia. Development and Evaluation of Micro Emulsion Formulations of Nebivolol for Solubility Enhancement, Journal of Drug Delivery and Therapeutics. 2021; 11(5):84-89.
Osama Umar, Kapil Kumar, Aparna Joshi, Dipti Khairiya, Deepak Teotia, Ikram. A comprehensive review on microemulsions: a potential novel drug delivery system. Int J Indig Herbs Drugs 2022; 7(3): 56-61.
Fialho SL, da Silva-Cunha A. New vehicle based on a microemulsion for topical ocular administration of dexamethasone. Cl i n Ex p e r Op h t h a lmo l., 2004; 32(6):626-632
Syamasri Gupta, S.P. Moulik, Biocompatible microemulsions an their prospective uses in drug delivery. Journal of Pharmaceutical Sciences. 2008; 97:22-45.
Yogeshwar G. Bachhav and Vandana B. Patravale; Microemulsion-Based Vaginal Gel of Clotrimazole: Formulation, In Vitro Evaluation, and Stability Studies; AAPS PharmSciTech; Vol. 10, No. 2, June 2009, 476-481.
Peter OI, Ifeoma UC. Development and evaluation of Albendazole microcapsule for colonic drug delivery system. Universal Journal of Pharmaceutical Research 2017; 2(2): 4-7.
E Gundogdu, I Gonzalez Alvarez, E Karasulu; Improvement of effect of water-in-oil microemulsion as an oral delivery system for fexofenadine: in vitro and in vivo studies; International Journal of Nanomedicine; 2011:6 1631–1640.
Nweje-Anyalowu Paul C, Anyalogbu Ernest AA, White Alalibo Jim. Design and evaluation of chronotherapeutic pulsatile drug delivery system of Cilnidipine. Universal Journal of Pharmaceutical Research 2017; 2(5): 15-18.
Amit A. Kale and Vandana B. Patravale; Development and Evaluation of Lorazepam Microemulsions for Parenteral Delivery; AAPS PharmSciTech.,9 (2008) 966-971.
Vandana Patel, Hirenkumar Kukadiya, Rajshree Mashru; Development of Microemulsion for Solubility Enhancement of Clopidogrel; Iranian Journal of Pharmaceutical Research., 9(4) (2010), 327-334.
Kaur G, Paliwal S. Formulation and evaluation of etoricoxib microbeads for sustained drug delivery. Universal Journal of Pharmaceutical Research 2019; 4(1): 35-39.
Park K M, Kim C K; Preparation and evaluation of flurbiprofen- loaded Microemulsions for parental delivery; Int J Pharm., 181 (1999) 173-179.
Sunday OS. Colon-targeted drug delivery systems: design, trends and approaches. Universal Journal of Pharmaceutical Research 2017; 2(4): 46-50.
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