Nanoemulgel: For Promising Topical and Systemic Delivery
Keywords:Nanoemulgel, nanoemulsion, bioavailability
A Nanoemulgel is a topical gel that contains a nanoemulsion dispersed within a gel matrix. The nanoemulsion is typically prepared using high shear mixing techniques and contains droplets of oil. The droplets size of nanoemulsion was in range of of 28 to 500nm. The sizes were confirmed by dynamic light scattering method. Nano-emulgel is an emerging drug delivery system intended to enhance the therapeutic profile of lipophilic drugs. Lipophilic formulations have a variety of limitations, which includes poor solubility, unpredictable absorption, and low oral bioavailability. Nano-emulgel, an amalgamated preparation of different systems aims to deal with these limitations. The novel system prepared by the incorporation of nano-emulsion into gel improves stability and enables drug delivery for both immediate and controlled release. Nanoemulgel improves the stability of a nanoemulsion formulation by lowering surface and interfacial tension, which increases the aqueous phase viscosity. Because the system has a higher viscosity than the nanoemulsion system, nanoemulgel is also known as hydrogel-thickened nanoemulsions. Hydrophobic medication delivery using nanoemulgel is extremely effective. Nanoemulgel use has increased in recent years as a result of the preparation's improved acceptability among patients due to its non-greasy, convenient Spread ability, easy application, and good therapeutic and safety profile.
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