Brief overview of Jaundice and its Current treatment options

Yash Srivastav; Akhandnath Prajapati

doi:10.47957/ijpda.v11i3.556

Authors

Yash Srivastav Goel Institute of Pharmacy & Sciences (GIPS), Lucknow, Uttar Pradesh, India
Akhandnath Prajapati Goel Institute of Pharmacy & Sciences (GIPS), Lucknow, Uttar Pradesh, India.

DOI:

https://doi.org/10.47957/ijpda.v11i3.556

Keywords:

Jaundice, Histology, Symptoms, Causes, Pathophysiology, Treatments

Abstract

The sickness of jaundice is intricate. The cause of jaundice is a high bilirubin level in the body. Jaundice commonly manifests as skin, mucous membranes, and skin that are yellow. Pre-hepatic jaundice is caused by hemolysis of red blood cells, hepatic jaundice is caused by a problem with the liver's ability to collect, conjugate, and excrete bilirubin, and post-hepatic jaundice is caused by the obstruction of the extra hepatobiliary system.When bilirubin is metabolised, red blood cells (RBCs) go through hemolysis and release haemoglobin as a result. Heme is broken down by the heme oxygenase in the reticuloendothelial system into biliverdin and carbon monoxide. Then, biliverdin is converted into unconjugated bilirubin by the enzyme biliverdin reductase. Jaundice typically manifests as extreme weakness, fever and a headache, decrease in appetite, extremely constipated, Nausea, urine, tongue, skin, and eyes that are all yellow, dull discomfort near the liver.In the entire world, liver disease is one of the leading causes of illness and mortality. The total number of liver disease-related deaths in India reached 2.95%, per W.H.O. data released in 2017. One in five Indians may have a liver disorder.The aetiology, causes, symptoms, and combination therapy of jaundice are covered in this review study.

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Author Biographies

Yash Srivastav, Goel Institute of Pharmacy & Sciences (GIPS), Lucknow, Uttar Pradesh, India

Goel Institute of Pharmacy & Sciences (GIPS), Lucknow, Uttar Pradesh, India.

Akhandnath Prajapati, Goel Institute of Pharmacy & Sciences (GIPS), Lucknow, Uttar Pradesh, India.

Goel Institute of Pharmacy & Sciences (GIPS), Lucknow, Uttar Pradesh, India.

References

Tewari D, Mocan A, Parvanov ED, Sah AN, Nabavi SM, Huminiecki L, et al. Ethnopharmacological approaches for therapy of jaundice: Part I. Front Pharmacol. 2017;8(AUG):1–18.

Click R, Dahl-Smith J, Fowler L, DuBose J, Deneau-Saxton M, Herbert J. An osteopathic approach to reduction of readmissions for neonatal jaundice. Osteopath Fam Physician [Internet]. 2013;5(1):17–23. Available from: http://dx.doi.org/10.1016/j.osfp.2012.09.005

Pyrz KE. Archive 1969. 1969;

Labori KJ, Bjørnbeth BA, Ræder MG. Aetiology and prognostic implication of severe jaundice in surgical trauma patients. Scand J Gastroenterol. 2003;38(1):102–8.

Hundt M, Basit H, John S. Physiology, Bile Secretion. [Updated 2022 Sep 26]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK470209/. 2023;470209.

Memon N, Weinberger BI, Hegyi T, Aleksunes LM. Inherited disorders of bilirubin clearance. Pediatr Res. 2016;79(3):378–86.

Bansal V, Schuchert VD. Jaundice in the Intensive Care Unit. Surg Clin North Am. 2006;86(6):1495–502.

Wheatley, M. and KLH. Jaundice: An emergency department approach to diagnosis and management. Emerg Med Pr 103 1-24. 2008;76(3):61–4.

Kumar KPS, Bhowmik D. Jaundice-review of clinical features, differential diagnosis and remedies. Pharma Res. 2011;4(2):241–52.

Brites D. The evolving landscape of neurotoxicity by unconjugated bilirubin: Role of glial cells and inflammation. Front Pharmacol. 2012;3 MAY(May):1–27.

Kruger D. The assessment of jaundice in adults: tests, imaging, differential diagnosis. JAAPA. 2011;24(6):44–9.

Suriyavathana M, Jeevitha M, Aranganathan J. In vitro antioxidant profile of Justicia tranquebariensis. J Pharm Res. 2011;4(11):4259–61.

Siddiqui M. Phytochemical Analysis of Some Medicinal Plants. Liaquat Med Res J. 2021;3(8):1–5.

Mishra D, Dash KR, Khatua C, Panigrahi S, Parida PK, Behera SK, et al. A Study on the Temporal Trends in the Etiology of Cirrhosis of Liver in Coastal Eastern Odisha. Euroasian J Hepato-Gastroenterology. 2020;10(1):1–6.

Singh J, Prakash C, Gupta RS, Bora D, Jain DC, Datta KK. Epidemiology of endemic viral hepatitis in an urban area of india: A retrospective community study in Alwar. Bull World Health Organ. 1997;75(5):463–8.

Poduri CD. Jaundice: A brief historical perspective. Apollo Med [Internet]. 2016;13(2):76–9. Available from: http://dx.doi.org/10.1016/j.apme.2014.05.014

Gao B, Bataller R. Alcoholic liver disease: Pathogenesis and new therapeutic targets. Gastroenterology. 2011;141(5):1572–85.

Riva MA, Riva E, Spicci M, Strazzabosco M, Giovannini M, Cesana G. “The city of Hepar”: Rituals, gastronomy, and politics at the origins of the modern names for the liver. J Hepatol. 2011;55(5):1132–6.

Bynum W. The history of medicine: a very short introduction.

Schmid R. History of viral hepatitis: A tale of dogmas and misinterpretations. J Gastroenterol Hepatol. 2001;16(7):718–22.

McDonald S. Acute yellow atrophy.

Trepo C. A brief history of hepatitis milestones. Liver Int. 2014;34(SUPPL1):29–37.

Thomas RE, Lorenzetti DL, Spragins W. Mortality and morbidity among military personnel and civilians during the 1930s and World War II from transmission of hepatitis during yellow fever vaccination: Systematic review. Am J Public Health. 2013;103(3).

Wahab MA, Yousaf M, Hossain ME. Some indigenous medicinal knowledge for treating jaundice in Chittagong hill tracts Bangladesh. Hamdard Med. 2004;47(4):55–8.

Amiri MS, Joharchi MR, TaghavizadehYazdi ME. Ethno-medicinal plants used to cure jaundice by traditional healers of Mashhad, Iran. Iran J Pharm Res. 2014;13(1):157–62.

Abbasi AM, Khan MA, Ahmad M, Zafar M, Khan H, Muhammad N, et al. Medicinal plants used for the treatment of jaundice and hepatitis based on socio-economic documentation. African J Biotechnol. 2009;8(8):1643–50.

Sarkhel S. Open Access Journal of Medicinal and Aromatic Plants Vol . 6 ( 2 ): 43-48 Ethnomedicinal uses of some plants in treatment of jaundice by tribal communities of Paschim Medinipur district , West Bengal , India. 2015;6(Oajmap):43–8.

Ebrahimi S, Ashkani-Esfahani S, Poormahmudi A. Investigating the efficacy of Zizyphus Jujuba on neonatal jaundice. Iran J Pediatr. 2011;21(3):320–4.

Janghel V, Patel P, Chandel SS. Plants used for the treatment of icterus (jaundice) in Central India: A review. Ann Hepatol [Internet]. 2019;18(5):658–72. Available from: https://doi.org/10.1016/j.aohep.2019.05.003

Raghuvanshi D, Dhalaria R, Sharma A, Kumar D, Kumar H, Valis M, et al. Ethnomedicinal plants traditionally used for the treatment of jaundice (Icterus) in himachal pradesh in western Himalaya—A review. Plants. 2021;10(2):1–19.

Pashankar D, Schreiber RA. Jaundice in older children and adolescents. Pediatr Rev. 2001;22(7):219–26.

Roy-Chowdhury, Namita, and Jayanta Roy-Chowdhury. “Classification and causes of jaundice or asymptomatic hyperbilirubinemia.” UpToDate 2011 (2011): 1-11. 2011;2011:2011.

Schlosser BJ, Pirigyi M, Mirowski GW. Oral manifestations of hematologic and nutritional diseases. Otolaryngol Clin North Am. 2011;44(1):183–203.

Zeitoun AA, Elhagrasy HF, Abdelsatar DM. Predictive value of umbilical cord blood bilirubin in neonatal hyperbilirubinemia. Egypt Pediatr Assoc Gaz [Internet]. 2013;61(1):23–30. Available from: http://dx.doi.org/10.1016/j.epag.2013.04.006

Dennery P, Seidman DS. 022201 Neonatal Hyperbilirubinemia. 2014;(March 2001).

Lauer BJ, Spector ND. Hyperbilirubinemia in the newborn. Pediatr Rev. 2011;32(8):341–9.

Juncker J. Conspectus medicinae theoretico-practicae.

Academy A, Pediatrics OF, Infant N, Weeks M. Weeks of Gestation. Pediatrics. 2004;114(1):297–316.

Behrman, Richard E., and Victor C. Vaughan III. Nelson textbook of pediatrics . No. Ed. 12. WB Saunders company, 1983. 1983;1983.

Manning D, Todd P, Maxwell M, Platt MJ. Prospective surveillance study of severe hyperbilirubinaemia in the newborn in the UK and Ireland. Arch Dis Child Fetal Neonatal Ed. 2007;92(5):342–6.

Abbas M, Shamshad T, Ashraf M, Javaid R. Jaundice: a basic review. Int J Res Med Sci. 2016;4(5):1313–9.

Rakhecha G, Parihar RR, Dhania B. Breastmilk jaundice: a nurse perspective. Int J Contemp Pediatr. 2022;9(11):1127.

Bratton S, Cantu RM SM. Breast Milk Jaundice. [Updated 2023 Jan 17] StatPearls [Internet] Treasure Isl StatPearls Publ 2023 Jan- Available from https//www.ncbi.nlm.nih.gov/books/NBK537334/. 2023;537334.

Janghel V, Patel P, Chandel SS. Plants used for the treatment of icterus (jaundice) in Central India: A review. Ann Hepatol. 2019;18(5):658–72.

Chen H, Ling W, Shang H, Hsu S, Hao L, Bang Y, et al. Jaundice revisited: recent advances in the diagnosis and treatment of inherited cholestatic liver diseases. J Biomed Sci. 2018;25(1):75.

Paumgartner G, Beuers U. Ursodeoxycholic acid in cholestatic liver disease: Mechanisms of action and therapeutic use revisited. Hepatology. 2002;36(3):525–31.

Chen HL, Chen HL, Yuan RH, Wu SH, Chen YH, Chien CS, et al. Hepatocyte transplantation in bile salt export pump-deficient mice: Selective growth advantage of donor hepatocytes under bile acid stress. J Cell Mol Med. 2012;16(11):2679–89.

Hayashi H, Sugiyama Y. 4-Phenylbutyrate enhances the cell surface expression and the transport capacity of wild-type and mutated bile salt export pumps. Hepatology. 2007;45(6):1506–16.

Hayashi H, Mizuno T, Horikawa R, Nagasaka H, Yabuki T, Takikawa H, et al. 4-Phenylbutyrate modulates ubiquitination of hepatocanalicular MRP2 and reduces serum total bilirubin concentration. J Hepatol [Internet]. 2012;56(5):1136–44. Available from: http://dx.doi.org/10.1016/j.jhep.2011.11.021

Gonzales E, Grosse B, Cassio D, Davit-Spraul A, Fabre M, Jacquemin E. Successful mutation-specific chaperone therapy with 4-phenylbutyrate in a child with progressive familial intrahepatic cholestasis type 2. J Hepatol [Internet]. 2012;57(3):695–8. Available from: http://dx.doi.org/10.1016/j.jhep.2012.04.017

Brems JJ, Reese J, Kane R, Kaminski DL. Effect of cyclosporine and steroids on canine bile flow. Hepatology. 1991;14(3):523–7.

Fardel O, Payen L, Courtois A, Vernhet L, Lecureur V. Regulation of biliary drug efflux pump expression by hormones and xenobiotics. Toxicology. 2001;167(1):37–46.

Warskulat U, Kubitz R, Wettstein M, Stieger B, Meier PJ, Häussinger D. Regulation of bile salt export pump mRNA levels by dexamethasone and osmolarity in cultured rat hepatocytes. Biol Chem. 1999;380(11):1273–9.

Kubitz R, Warskulat U, Schmitt M, Häussinger D. Dexamethasone- and osmolarity-dependent expression of the multidrug-resistance protein 2 in cultured rat hepatocytes. Biochem J. 1999;340(3):585–91.

Miethke AG, Zhang W, Simmons J, Taylor AE, Shi T, Shanmukhappa SK, et al. Pharmacological inhibition of apical sodium-dependent bile acid transporter changes bile composition and blocks progression of sclerosing cholangitis in multidrug resistance 2 knockout mice. Hepatology. 2016;63(2):512–23.

Engelmann G, Wenning D, Herebian D, Sander O, Dröge C, Kluge S, et al. Two case reports of successful treatment of cholestasis with steroids in patients with PFIC-2. Pediatrics. 2015;135(5):e1326–32.

Heubi JE, Bove KE, Setchell KDR. Oral Cholic Acid Is Efficacious and Well Tolerated in Patients with Bile Acid Synthesis and Zellweger Spectrum Disorders. J Pediatr Gastroenterol Nutr. 2017;65(3):321–6.

Dai D, Mills PB, Footitt E, Gissen P, McClean P, Stahlschmidt J, et al. Liver disease in infancy caused by oxysterol 7?-hydroxylase deficiency: successful treatment with chenodeoxycholic acid. J Inherit Metab Dis. 2014;37(5):851–61.

Aslam MS, Raheel R, Asghar S, Sciences A, Ashraf M, Sciences A. Phytochemical, Ethnopharmacological Review of Acacia Nilotica (Desi Kikar) and Taxo-Pharmacology of Genus Acacia. Indian Res J Pharm Sci [Internet]. 2014;(October 2015). Available from: http://irjps.in/journal/9.pdf

Singh, U. and AKB. Ethnobotanical study of plants of Raigarh area, Chhattisgarh, India. Int Res J Biol Sci 46 36-43. 2015;151:10–7.

Kannan N, Sakthivel KM, Guruvayoorappan C. Protective effect of acacia nilotica (L.) against acetaminophen-induced Hepatocellular Damage in Wistar rats. Adv Pharmacol Sci. 2013;2013.

Singh BN, Singh BR, Sarma BK, Singh HB. Potential chemoprevention of N-nitrosodiethylamine-induced hepatocarcinogenesis by polyphenolics from Acacia nilotica bark. Chem Biol Interact. 2009;181(1):20–8.

Kushwaha K, Tripathi RK, Dwivedi S. INTERNATIONAL JOURNAL OF PHARMACY & LIFE SCIENCES Medicinal plants used in the treatment of some common diseases by the tribal and rural people in Korea district of Chhatisgarh. Int J Pharm Life Sci. 2013;4(10):3023–7.

Sharma, R., and A. Ekka. “Diversity of medicinal plants in Pt. Ravishankar Shukla University campus, Raipur, Chhattisgarh, India.” Eur J Pharma Medic Res 3 (2016): 383-397. 2016;3:2016.

Garaniya N, Bapodra A. Ethno botanical and Phytophrmacological potential of Abrus precatorius L.: A review. Asian Pac J Trop Biomed. 2014;4(Suppl 1):S27–34.

Battu GR, Kumar BM, Division P, Pradesh A. Battu and Kumar hepatoprotective activity of abrus precatorius linn . against paracetamol Battu and Kumar. 2009;375:366–75.

U. Tewari, A.N. Bahadur, P. Soni SP. Medicinal uses of some threatened species of wild herbal plants from Bilaspur district. Indian J Sci Res. 2014;4(1):64–9.

Nithianantham K, Shyamala M, Chen Y, Latha LY, Jothy SL, Sasidharan S. Hepatoprotective potential of clitoria ternatea leaf extract against paracetamol induced damage in mice. Molecules. 2011;16(12):10134–45.

Nithianantham K, Ping KY, Latha LY, Jothy SL, Darah I, Chen Y, et al. Evaluation of hepatoprotective effect of methanolic extract of Clitoria ternatea (Linn.) flower against acetaminophen-induced liver damage. Asian Pacific J Trop Dis. 2013;3(4):314–9.

Somania R, Vadnala P, Deshmukhb S, Patwardhana S. Hepatoprotective activity of Clitoria ternatea L. leaves against carbon tetrachloride induced hepatic damage in rats. J Pharm Res. 2011;4(10):3540–4.

Wadekar R, Supale R, Tewari K, Patil K, Jalalpure S. Screening of roots of Baliospermum montanum for hepatoprotective activity against paracetamol induced liver damage in albino rats. Int J Green Pharm. 2008;2(4):220.

Kumar KS, Rao AS. Evaluation of hepatoprotective and invitro cytotoxic activity of leaves of Chrozophora plicata Linn . Res J Pharmacol Pharmacodyn. 2017;9(1):19.

Tabassum, Nahid and SSA. "Hepatoprotective activity of Eclipta alba Hassk. against paracetamol induced hepatocellular damage in mice. JK-practitioner 114 278-280. 2004;4(1):1–14.

Beedimani, Ravindra S., and Shivkumar Shetkar. “Hepatoprotective activity of Eclipta alba against carbon tetrachlorideinduced hepatotoxicity in albino rats.” (2015). 2015;2015.

Pramyothin P, Ngamtin C, Poungshompoo S, Chaichantipyuth C. Hepatoprotective activity of Phyllanthus amarus Schum. et. Thonn. extract in ethanol treated rats: In vitro and in vivo studies. J Ethnopharmacol. 2007;114(2):169–73.

Sattar, Md Abdul et al. "Pharmacological evaluation of P. amarus seeds and L. aspera leaves for its hepatoprotective and nephroprotective activities. Res J Pharm Biol Chem Sci 61 1017-1025. 2015;1(16.1.2015):2015.

Heubi JE, Setchell KDR, Bove KE. Inborn Errors of Bile Acid Metabolism. Clin Liver Dis [Internet]. 2018;22(4):671–87. Available from: https://doi.org/10.1016/j.cld.2018.06.006

Saheki T, Kobayashi K. Mitochondrial aspartate glutamate carrier (citrin) deficiency as the cause of adult-onset type II citrullinemia (CTLN2) and idiopathic neonatal hepatitis (NICCD). J Hum Genet. 2002;47(7):333–41.

Cong Liu*, Bruce J. Aronow, Anil G. Jegga, Ning Wang, Alex Miethke, Reena Mourya and JAB. Novel resequencing chip customized to diagnose mutations in patients with inherited syndromes of intrahepatic cholestasis. NIH Public Access Author Manuscr Gastroenterol Author manuscript; available PMC 2008 January 10 Publ [Internet]. 2007;117(25):1–21. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3624763/pdf/nihms412728.pdf