THE STUDY OF THE EFFECTS OF PREDNISOLONE ON THE CEREBRAL CORTEX OF WISTAR RATS
Keywords:Prednisolone, Effects, cerebral cortex, corticosteroid, neurodegeneration and wistar rats
Prednisolone is an oral, synthetic (man-made) corticosteroid used for suppressing the immune system and inflammation. It
belongs to the general class of medicines called „steroids? which are used to treat a number of conditions; for example
inflammation, asthma, arthritis and allergic reactions. Steroids are used with other medicines to prevent the body from
rejecting transplanted organ. The purpose of this study was to evaluate the possible effects that Prednisolone could have on
the cerebral cortex of wistar rats. Twenty (20) wistar rats were used for this experiment; they were divided into four groups
with each group consisting of five Wistar rats. Group I was the control, while groups II, III, and IV were given 5mg/kg,
15mg/kg and 20mg/kg of Prednisolone respectively for a period of fourteen (14) days via oral intubations. The brain tissues
were fixed, processed and stained in haematoxylin and eosin; and the slides were viewed under the light microscope fitted
with a digital camera and laptop. Our results showed neuronal degeneration of the cerebral cortex of the Prednisolone
treated groups when compared with the control. Based on our observations, we therefore conclude that Prednisolone
administration resulted into neurodegeneration of the cerebral cortex of Wistar rats.
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