Pharmaceutical Standardization of Siddha Herbo-Mineral formulation of Kodi Pavala Chunnam

Authors

  • Govindaraj B PG Scholar, Post Graduate Department of Gunapadam (Pharmacology), Govt. Siddha Medical College, Chennai, Tamilnadu, India
  • Vajahath Ali A PG Scholar, Post Graduate Department of Gunapadam (Pharmacology), Govt. Siddha Medical College, Chennai, Tamilnadu, India
  • Saravana Devi M.D Professor, Head of the department, Post Graduate Department of Gunapadam (Pharmacology), Govt.Siddha Medical College, Chennai, TN, India
  • Velpandian V Professor, PG, Gunapadam Department (Pharmacology), Govt.Siddha Medical College, Chennai, TN, India

DOI:

https://doi.org/10.47957/ijpda.v10i2.503

Keywords:

Cholelithiasis, Kodi pavala chunnam, herbo mineral, Siddha medicine, alkaline

Abstract

Background: The present study is anticipated the perspective of physico chemical characteristics of the traditional Siddha medicine Kodi pavala chunnam . It is a herbo mineral formulation which treats the Cholelithiasis & it's related symptoms. Materials and Methods: The drug was prepared as mentioned in the Siddha literature Noigaluku Siddha parigaaram part 2 .Then the prepared drug was undergone physicochemical, biochemical, organoleptic and phytochemical analysis and HPTLC. Results: Loss on drying at 105°C was 0.8667 ± 0.4041,Total ash (%) was 55.67 ± 9.603,Acid insoluble ash (%) 0.64 ± 0.02,Water soluble extractive was 3.1 ± 1.044, Alcohol soluble extractive (%) was 0.2533 ± 0.0611, the PH was 8 which indicates alkaline nature of the drug. From the results the drug was free from microbial contamination . Heavy metals and Pesticide residues were below the quantification limit.Conclusion: The result shows that the  drug is of standard quality and can be used as reference in laying pharmacopoeia standards. From the results obtained in the above investigations it was concluded that the drug is effective biologically active components which may helps in treating cholelithiasis and it's related ailments.

Downloads

Download data is not yet available.

References

.References

Introduction and history of siddha [Internet]. National Health Portal. 2015. Available from: https://www.nhp.gov.in

R.Thiagarajan B.I.M.Gunapadam Thathu Jeeva Vaguppu 4th Edition 2004;Published By Indian Medicine and Homeopathy Dept.Chennai 106;p.

M.Shanmugavel H.B.I.M.Noigalukku Siddha Parigaram Part-2.1993; Department of Indian medicine and Homeopathy, Chennai-106;p.73-74.

Aanaivaari Anadhan. Sarakku Suththi Muraigal. Department of Indian medicine and Homeopathy, Chennai-106; 2008.p. 6-13.

India Pharmacopeia I Volume I, Government of India, Ministry of Health and Family welfare, Indian Pharmacopoeia commission, 2014.

Protocol for Testing of Ayurvedic Siddha and Unani medicines [Internet]. Ghaziabad: Department of AYUSH, Pharmacopoeial Laboratory for Indian Medicines; 2008. P. 49-50. Available from: https://www.researchgate.net

Brain KR, Turner TD. The Practical Evaluation of Phytopharmaceuticals. Bristol: Wright Scientechnica; 1975.p. 36-45

Wagner H. Plant Drug Analysis. A thin Layer chromatography Atlas.2nd ed. Heidelberg: Springer-Verlag Belgium; 2002. p. 305, 227.

Protocol for Testing of Ayurvedic Siddha and Unani medicines [Internet]. Ghaziabad: Department of AYUSH, Pharmacopoeial Laboratory for Indian Medicines; 2008. p. 69-73.Available from: https://www.researchgate.net

Pour Plate Method: Procedure, Uses, (Dis) Advantages • Microbe Online [Internet]. Microbe Online. 2022 [cited 13 April 2022]. Available from: https://microbeonline.com

Performance Standards for Antimicrobial Disk Susceptibility Tests; Approved Standard-11th ed. CLSI document M02-A11. Wayne, PA: Clinical and Laboratory Standards Institute; 2012.

WHO guidelines for assessing quality of herbal medicines with reference to contaminants and residues [Internet]. 2007. Available from: https://www.who.int

Protocol for Testing of Ayurvedic Siddha and Unani medicines [Internet]. Ghaziabad: Department of AYUSH, Pharmacopoeial Laboratory for Indian Medicines; 2008. p. 94-97.Available from: https://www.researchgate.net

Castro L de, Vargas EA. Determining aflatoxins B1, B2, G1 and G2 in maize using florisil clean up with thin layer chromatography and visual and densitometric quantification. Food Sci Technol [Internet]. 2001;21(1):116. Available from: http://dx.doi.org/10.1590/s0101-20612001000100024

Khandelwal K. Practical Pharmacognosy. Maharashtra: Niral Prakashan; 2008.

Nilakshi Pradhan, Jyoti Gavali,Nitin Waghmare. WHO (World Health Organization) Guidelines for Standardization of Herbal Drugs. International Ayurvedic Medical Journal. 2015;3(8):2239.

Khandelwal KR. Practical Pharmacognosy Techniques and Experiments. 20th ed. Pune, India: Nirali Prakashan; 2010. p. 23.1-23.17, 25.1-25.9

Aziz N, Wal P, Wal A, et.al. Evaluation of a Poly-herbal Powder for Treatment of Diabetes Mellitus. Indian Journal of Pharmaceutical Sciences. 2019;81(6).1072

Kaneria M, Chanda S. Phytochemical and Pharmacognostic Evaluation of Leaves of Psidium guajava L. (Myrtaceae). Pharmacog J. 2011;3(23):41–45

Savjani KT, Gajjar AK, Savjani JK. Drug Solubility: Importance and Enhancement Techniques. ISRN Pharmaceutics. 2012;2012:195727:2

L Patwekar, S., Arvind B, S. and Manoj, G., et.al 2016. Standardization of herbal drugs: An overview. The Pharma Innovation Journal, 4, p.100.

Babu, Ashok, Mahalakshmi, Vasudevan. Medicinal uses of plant secondary metabolites: A short review. International Journal of Zoological Investigations [Internet]. 2021;7(2):855–8.

Medicinally Important Phytochemicals: An Untapped Research Avenue. Research & Reviews: Journal of Pharmacognosy and Phytochemistry. 2016;4(1).40

S.Shaban n. Beni-Suef University Journal of Basic and Applied Sciences. 2016;5:103-104.

Siddique N, Mujeeb M, Ahmad S, Panda B, Makhmoor M. Determination of Aflatoxins in Medicinal Plants by High-Performance Liquid Chromatography–Tandem Mass Spectrometry. J Pharm Pharm Sci.2013;16(2):321

Seethalakshmi B, Kavitha K. Qualitative Analysis of Inorganic Acid, Basic Radicals, and Estimation of Biomolecules in the Flower Extract of Butea Superba Roxb. Asian Journal of Pharmaceutical and Clinical Research. 2018;11(10):161.

Published

2022-07-07
Statistics
203 Views | 96 Downloads
Citatons

How to Cite

B, G., V. A. A, S. D. M.D, and V. V. “Pharmaceutical Standardization of Siddha Herbo-Mineral Formulation of Kodi Pavala Chunnam”. International Journal of Pharmaceutics and Drug Analysis, vol. 10, no. 2, July 2022, pp. 38-45, doi:10.47957/ijpda.v10i2.503.

Issue

Section

Research Articles
Share |