FORMULATION AND EVALUATION OF ELETRIPTAN HYDRO- BROMIDE MICROSPHERES BY USING NATURAL POLYMERS

Authors

  • R.Manivannan Department of Pharmaceutics, JKKMMRF’s- Annai JKK Sampooraniammal College of Pharmacy, Ethirmedu, B.Komarapalayam, Namakkal (DT), Tamilnadu, India.
  • Mahaboob Ali Baig Department of Pharmaceutics, JKKMMRF’s- Annai JKK Sampooraniammal College of Pharmacy, Ethirmedu, B.Komarapalayam, Namakkal (DT), Tamilnadu, India.
  • M.Purushothaman Department of Pharmaceutics, Aadhi Bhagawan College of Pharmacy, Cheyyar (TK), Thiruvanamalai (DT), Tamilnadu, India.
  • N.Senthil kumar Department of Pharmaceutics, Aadhi Bhagawan College of Pharmacy, Cheyyar (TK), Thiruvanamalai (DT), Tamilnadu, India.

Keywords:

Eletriptan, Chitosan, SEM analysis and in-vitro studies

Abstract

Purpose: The aim of present work to develop competent and efficient sustained release microspheres of Eletriptan hydrobromide, prepared by Ionotropic gelation technique in order to reduce the frequency of administration and achieve patient compliance.

Method: Microspheres of Eletriptan hydrobromide were prepared by Ionic gelation method using natural polymers like sodium alginate, chitosan, karaya gum and guar gum. The morphology, particle size distribution and production yield were investigated. Release of Eletriptan hydrobromide was evaluated by In-vitro dissolution method using USP type I apparatus.

Result: Results showed that microspheres were spherical, discrete in shape. The percentage yield of the prepared microspheres was found to be 80.46% to 87.12%. Particle size distribution of the prepared microspheres was in the range of 487.0 – 802.5?m. In-vitro release studies revealed a controlled release of microspheres suitable for preoral administration. Formulation FEC1 showed 90.82% ± 0.26 of drug release for 12 hours in predetermined rate.

Conclusion: Based on the results the formulation FEC1 was found to be best when compared to other formulations.

Downloads

Download data is not yet available.

References

Akashmoy Chakraborty et al. Ionotropic Gelation Method of Sodium Alginte Microspheres. International journal of Comprehensive Pharmacy. 2011; 7 (07): 0976-8157.

Chinna Gangadhar et al. Indomethacin microspheres using natural and synthetic polymer as controlled release. International Jornal of Drug Discovery. 2010; 2(1): 08-16.

Shravan Kumar K et al. comparision of calcium silicate and cholestyramine based Eletriptan hydrobromide floating microspheres. Journal of drug delivery and therapeutics. 2013: 3(3): 104-112.

Chittam SS et al. Mucoadhesive microspheres of Norfloxacin. International Journal of Pharmaceutical Research. 2012; 2(6).

Durgacharan A Bhagwat et al. Controlled release microspheres of Isosorbode dinitrate. International Journal of Pharma Tech Research. 2009; 1(2): 125-128.

Prashanth VV et al. Microsphere over view. International Journal of Research in Pharmaceutical and Bio-medical Sciences. 2011; 2(2): 2229-3701.

Rajmanikam Deveswaran et al. Formulation and Evaluation of Albumin Microspheres Containing Aceclofenac. International Journal of Pharmaceutical Sciences Review and Research. 2010; 4(1): 0976-044X.

Roy Sl. Preparation on Microspheres of Mefenemic acid. International Journal of Pharmaceutical Sciences and Drug Research. 2009; 1(1): 36-42.

Senthil S Periyasamy et al. Microspheres containing Imatinib Mesylate using sodium alginate by chemical cross linking method. Journal of Drug Delivery & Therapeutics. 2012; 2(6): 37-40.

Vikas Parasar et al. Biodgradable microspheres of Tinidazole. International Journal of Drug Delivery2. 2010; 0975-0215.

Published

2014-04-15
Statistics
28 Views | 26 Downloads
Citatons

How to Cite

R.Manivannan, Mahaboob Ali Baig, M.Purushothaman, and N.Senthil kumar. “FORMULATION AND EVALUATION OF ELETRIPTAN HYDRO- BROMIDE MICROSPHERES BY USING NATURAL POLYMERS”. International Journal of Pharmaceutics and Drug Analysis, vol. 2, no. 4, Apr. 2014, pp. 347-53, https://ijpda.com/index.php/journal/article/view/50.

Issue

Section

Research Articles
Share |