Solid Dispersion Preparation by Different Methods to Improve Solubility & Dissolution Simvastatin
Keywords:Simvastatin, Hydroxy Propyl Methyl Cellulose, gum acacia, Solubility, Dissolution rate
The improvement of a pure drug's solubility and dissolution rate in the treatment of hyperlipidemia. Simvastatin is a 5-percent absolute bioavailability selective competitive inhibitor of HMG Co-A reductase. For the selection of the carrier, a preliminary solubility investigation of solid dispersion was performed, and solid dispersion was made using Hydroxy Propyl Methyl Cellulose (HPMC) and gum acacia. Solid dispersion of medication with polymer was created and studied for solubility and in-vitro dissolution profile. Solid dispersion of drug with polymer has shown an increase in solubility and improved dissolution rate. On the obtained formulations, further FTIR, X-Ray, Scanning electron microscopy, and Differential scanning calorimetry experiments were conducted. The existence of amorphous form in a solid dispersion made with polymer in a 1:5 ratio is verified by characterization research. The research also showed that using a solid dispersion approach with Polymer, the dissolving rate of a pure medication may be significantly increased.
Armstrong NA. Pharmaceutical Experimental Design and Interpretation, 2n ed., Taylor & Francis Group; 2006.
Ambike AA, Mahadik RK., Paradkar K.Spray- Dried Amorphous Solid Dispersions of Simvastatin, a Low Tg In Vitro and invivo Evaluations Pharmaceutical Research 2005;990-998.
SeoungWookJun , Min-Soo Kim , Jeong-Soo Kim , Hee Jun Park , Sibeum Lee ,Jong Soo Woo Sung-Joo Hwang Preparation and characterization simvastatin/hydroxypropyl-b-cyclodextrin inclusion complex using supercritical antisolvent (SAS) process European Journal of Pharmaceutics and Biopharmaceutics 66 (2007) 413–421.
Zhiwen Z, Huihui Bua, Zhiwei G, Yan H, Fang G, Yaping L. The characteristics and mechanism of simvastatin loaded lipid nanoparticles to increase oral bioavailability in rats International Journal of Pharmaceutics,2010,147- 153.
Galichet LY. Clarke’s Analysis of Drugs and Poisons. 3rd ed. Pharmaceutical Press. September 2005.
www. Drug.com / Drug interactions/ Side effects.
Sharma Daisy, SoniMohit, Kumar Sandeep, Gupta G.D. Solubility Enhancement – Eminent Role in Poorly Soluble Drugs.Research J. Pharm. and Tech 2009; 2(2): 220-224.
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