Understanding menopause-postmenopausal complications, management and quality of life

Authors

  • Timmana.V.S.Geethika Department of Pharmacy, Avanthi Institute of Pharmaceutical Sciences, Cherukupally (v), Bhogapuram (m), near Tagarapuvalasa bridge, Vizianagaram district, Andhra Pradesh,India
  • Glory Mattapalli Department of Pharmacy, Avanthi Institute of Pharmaceutical Sciences, Cherukupally (v), Bhogapuram (m), near Tagarapuvalasa bridge, Vizianagaram district, Andhra Pradesh,India
  • Emmanuel Gujju Department of Pharmacy, Avanthi Institute of Pharmaceutical Sciences, Cherukupally (v), Bhogapuram (m), near Tagarapuvalasa bridge, Vizianagaram district, Andhra Pradesh,India
  • Priyanka Boddu Department of Pharmacy, Avanthi Institute of Pharmaceutical Sciences, Cherukupally (v), Bhogapuram (m), near Tagarapuvalasa bridge, Vizianagaram district, Andhra Pradesh,India

DOI:

https://doi.org/10.47957/ijpda.v9i2.473

Keywords:

Menopause, quality of life, postmenopausal women, complications

Abstract

Menopause is a commonly occurring transition that all women go through with advancing age. The permanent cessation of menstruation is defined as natural menopause it happens with the termination of a woman’s final menstrual period. Variations in race and ethnicity may be a reason for different menopausal onsets in women which may also be affected by lifestyle and demographic factors. A negative effect on the common health and quality of life (QOL) as well as the contentment of middle-aged women may occur due to Menopause and associated biological changes. From one individual to another, symptoms of menopause and their severity differ due to the effects of different factors such as social status, lifestyle, psychological status, and body composition. QOL in women may be diminished due to Menopausal symptoms, mostly sexual and vasomotor symptoms.

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References

Bauld R, Brown RF. Stress, psychological distress, psychosocial factors, menopause symptoms and physical health in women. Maturitas. 2009 Feb 20;62(2):160-5.

Meeta M, Digumarti L, Agarwal N, Vaze N, Shah R, Malik S. Clinical practice guidelines on menopause:* An executive summary and recommendations: Indian menopause society 2019–2020. Journal of Mid-life Health. 2020 Apr;11(2):55.

George SA. The menopause experience: a woman's perspective. Journal of Obstetric, Gynecologic, & Neonatal Nursing. 2002 Jan;31(1):77-85.

Simoncini T, Caretto M, Giannini A, Genazzani AR. Diagnosis of Menopause

Avis NE, Kaufert PA, Lock M, McKinlay SM, Vass K. 2 The evolution of menopausal symptoms. Baillière's clinical endocrinology and metabolism. 1993 Jan 1;7(1):17-32.

Gold EB. The timing of the age at which natural menopause occurs. Obstetrics and Gynecology Clinics. 2011 Sep 1;38(3):425-40.

Torgerson DJ, Avenell A, Russell IT, Reid DM. Factors associated with onset of menopause in women aged 45–49. Maturitas. 1994 Aug 1;19(2):83-92.

Snieder H, MacGregor AJ, Spector TD. Genes control the cessation of a woman’s reproductive life: a twin study of hysterectomy and age at menopause. The Journal of Clinical Endocrinology & Metabolism. 1998 Jun 1;83(6):1875-80.

Whelan EA, Sandler DP, McConnaughey DR, Weinberg CR. 90137575 Menstrual and reproductive characteristics and age at n`atural menopause. Maturitas. 1990 Nov 1;12(4):371.

Bromberger JT, Matthews KA, Kuller LH, Wing RR, Meilahn EN, Plantinga P. Prospective study of the determinants of age at menopause. American journal of epidemiology. 1997 Jan 15;145(2):124-33.

Kaye SA, Folsom AR, Prineas RJ, Potter JD, Gapstur SM. The association of body fat distribution with lifestyle and reproductive factors in a population study of postmenopausal women. International journal of obesity. 1990 Jul 1;14(7):583-91.

Weel AE, Uitterlinden AG, Westendorp IC, Burger H, Schuit SC, Hofman A, Helmerhorst TJ, van Leeuwen JP, Pols HA. Estrogen receptor polymorphism predicts the onset of natural and surgical menopause. The Journal of Clinical Endocrinology & Metabolism. 1999 Sep 1;84(9):3146-50.

He C, Kraft P, Chen C, Buring JE, Paré G, Hankinson SE, Chanock SJ, Ridker PM, Hunter DJ, Chasman DI. Genome-wide association studies identify loci associated with age at menarche and age at natural menopause. Nature genetics. 2009 Jun;41(6):724-8.

Lu Y, Liu P, Recker RR, Deng HW, Dvornyk V. TNFRSF11A and TNFSF11 are associated with age at menarche and natural menopause in white women. Menopause (New York, NY). 2010 Sep;17(5):1048.

Greendale GA, Hogan P, Kritz-Silverstein D, Langer R, Johnson SR, Bush T. Age at menopause in women participating in the postmenopausal estrogen/progestins interventions (PEPI) trial: an example of bias introduced by selection criteria. Menopause. 1995 Jan 1;2(1):27-34.

Lindquist O, Bengtsson C. Menopausal age in relation to smoking. Acta Medica Scandinavica. 1979 Jan 12;205(1?6):73-7

Cummings SR, Kelsey JL, Nevitt MC, O'DOWD KJ. Epidemiology of osteoporosis and osteoporotic fractures. Epidemiologic reviews. 1985 Jan 1;7(1):178-208.

Harlow SD, Gass M, Hall JE, Lobo R, Maki P, Rebar RW, Sherman S, Sluss PM, De Villiers TJ, STRAW+ 10 Collaborative Group. Executive summary of the Stages of Reproductive Aging Workshop+ 10: addressing the unfinished agenda of staging reproductive aging. The Journal of Clinical Endocrinology & Metabolism. 2012 Apr 1;97(4):1159-68.

World Health Organization. Research on the menopause in the 1990s: report of a WHO scientific group. World Health Organization; 1996.

Gracia CR, Freeman EW. Onset of the menopause transition: the earliest signs and symptoms. Obstetrics and Gynecology Clinics. 2018 Dec 1;45(4):585-97.

Rapkin AJ. Vasomotor symptoms in menopause: physiologic condition and central nervous system approaches to treatment. American journal of obstetrics and gynecology. 2007 Feb 1;196(2):97-106.

Hutton JD, Murray MA, Jacobs HS, James VH. Relation between plasma oestrone and oestradiol and climacteric symptoms. The Lancet. 1978 Apr 1;311(8066):678-81.

Deecher DC, Leventhal L, Numan S, Sipe K, Cosmi S, Merchenthaler I. Desvenlafaxine alleviates vasomotor instability in two rodent models of hot flush. Collegeville (PA): Women’s Health Research Institute, Wyeth Research. 2005.

Gold EB, Colvin A, Avis N, Bromberger J, Greendale GA, Powell L, Sternfeld B, Matthews K. Longitudinal analysis of the association between vasomotor symptoms and race/ethnicity across the menopausal transition: study of women’s health across the nation. American journal of public health. 2006 Jul;96(7):1226-35.

Mayou R, Farmer A. Functional somatic symptoms and syndromes. Bmj. 2002 Aug 3;325(7358):265-8.

Brincat MP, Muscat Baron Y, Galea R. Estrogens and the skin. Climacteric. 2005 Jun 1;8(2):110-23.

Davis SR, Castelo-Branco C, Chedraui P, Lumsden MA, Nappi RE, Shah D, Villaseca P, Writing Group of the International Menopause Society for World Menopause Day 2012. Understanding weight gain` at menopause. Climacteric. 2012 Oct 1;15(5):419-29.

Schaffer J, Fantl JA. 4 Urogenital effects of the menopause. Baillière's clinical obstetrics and gynaecology. 1996 Sep 1;10(3):401-17.

Rekers H, Drogendijk AC, Valkenburg HA, Riphagen F. The menopause, urinary incontinence and other symptoms of the genito-urinary tract. Maturitas. 1992 Oct 1;15(2):101-11.

Joffe H, Massler A, Sharkey KM. Evaluation and management of sleep disturbance during the menopause transition. InSeminars in reproductive medicine 2010 Sep (Vol. 28, No. 5, p. 404). NIH Public Access.

Freedman RR, Roehrs TA. Sleep disturbance in menopause. Menopause. 2007 Sep 1;14(5):826-9.

Harris AL, Harrison A. Examining sleep disturbance during the menopausal period. Nursing for women's health. 2020 Apr 1;24(2):134-42.

Tang R, Luo M, Li J, Peng Y, Wang Y, Liu B, Liu G, Wang Y, Lin S, Chen R. Symptoms of anxiety and depression among Chinese women transitioning through menopause: findings from a prospective community-based cohort study. Fertility and sterility. 2019 Dec 1;112(6):1160-71.

Bromberger JT, Kravitz HM, Chang Y, Randolph Jr JF, Avis NE, Gold EB, Matthews KA. Does risk for anxiety increase during the menopausal transition? Study of Women's Health Across the Nation (SWAN). Menopause (New York, NY). 2013 May;20(5):488.

Mihmanli I, Kantarci F. Postmenopausal Bleeding. Ultrasound Clinics. 2008 Jul 1;3(3):391-7.

Smith PP, O'Connor S, Gupta J, Clark TJ. Recurrent postmenopausal bleeding: a prospective cohort study. Journal of minimally invasive gynecology. 2014 Sep 1;21(5):799-803.

American College of Obstetricians and Gynecologists. ACOG committee opinion no. 734: the role of transvaginal ultrasonography in evaluating the endometrium of women with postmenopausal bleeding. Obstet Gynecol. 2018;131(5):e124-9.

Hsu CY, Chen CP, Wang KL. Assessment of postmenopausal bleeding. International Journal of Gerontology. 2008 Jun 1;2(2):55-9.

Burke TN, França FJ, Meneses SR, Cardoso VI, Pereira RM, Danilevicius CF, Marques AP. Postural control among elderly women with and without osteoporosis: is there a difference?. Sao Paulo Medical Journal. 2010 Jul;128(4):219-24.

Li J, Chen X, Lu L, Yu X. The relationship between bone marrow adipose tissue and bone metabolism in postmenopausal osteoporosis. Cytokine & growth factor reviews. 2020 Apr 1;52:88-98.

Black DM, Rosen CJ. Postmenopausal osteoporosis. New England Journal of Medicine. 2016 Jan 21;374(3):254-62.

Madrasi K, Li F, Kim MJ, Samant S, Voss S, Kehoe T, Bashaw ED, Ahn HY, Wang Y, Florian J, Schmidt S. Regulatory perspectives in pharmacometric models of osteoporosis. The Journal of Clinical Pharmacology. 2018 May;58(5):572-85.

Camanho GL, Imamura M, Arendt-Nielsen L. Gênese da dor na artrose. Rev. bras. ortop. 2011:14-7.

Kellgren JH, Moore R. Generalized osteoarthritis and Heberden's nodes. British medical journal. 1952 Jan 26;1(4751):181.

Hanna FS, Wluka AE, Bell RJ, Davis SR, Cicuttini FM. Osteoarthritis and the postmenopausal woman: epidemiological, magnetic resonance imaging, and radiological findings. InSeminars in arthritis and rheumatism 2004 Dec 1 (Vol. 34, No. 3, pp. 631-636). WB Saunders.

Nevitt MC, Felson DT. Sex hormones and the risk of osteoarthritis in women: epidemiological evidence. Annals of the rheumatic diseases. 1996 Sep;55(9):673.

Paschou SA, Marina LV, Spartalis E, Anagnostis P, Alexandrou A, Goulis DG, Lambrinoudaki I. Therapeutic strategies for type 2 diabetes mellitus in women after menopause. Maturitas. 2019 Aug 1;126:69-72.

Xu Y, Lin J, Wang S, Xiong J, Zhu Q. Combined estrogen replacement therapy on metabolic control in postmenopausal women with diabetes mellitus. The Kaohsiung journal of medical sciences. 2014 Jul 1;30(7):350-61.

Gonzalez C, Alonso A, Alvarez N, Diaz F, Martinez M, Fernandez S, Patterson AM. Role of 17beta-estradiol and/or progesterone on insulin sensitivity in the rat: implications during pregnancy. Journal of Endocrinology. 2000 Aug 1;166(2):283-91.

De Paoli M, Werstuck GH. Role of estrogen in type 1 and type 2 diabetes mellitus: a review of clinical and preclinical data. Canadian journal of diabetes. 2020 Jan 12.

Indumathy P, Santhiya J. Prevalence of Anaemia among Postmenopausal Women in Karunmandi Chellipalayam Panchayat of Perundurai Taluk in Erode District.

Zaman A, Rothman MS. Postmenopausal Hyperandrogenism: Evaluation and Treatment Strategies. Endocrinology and Metabolism Clinics. 2021 Mar 1;50(1):97-111.

Alpanes M, Gonzalez-Casbas JM, Sanchez J, Pian H, Escobar-Morreale HF. Management of postmenopausal virilization. The Journal of Clinical Endocrinology & Metabolism. 2012 Aug 1;97(8):2584-8.

Thomas PK, Ferriman DG. Variation in facial and pubic hair growth in white women. American journal of physical anthropology. 1957 Jun;15(2):171-80.

Hershman JM, Pekary AE, Berg L, Solomon DH, Sawin CT. Serum thyrotropin and thyroid hormone levels in elderly and middle?aged euthyroid persons. Journal of the American Geriatrics Society. 1993 Aug;41(8):823-8.

Mazzaferri EL. Evaluation and management of common thyroid disorders in women. American journal of obstetrics and gynecology. 1997 Mar 1;176(3):507-14

Mazzaferri EL, Jhiang SM. Long-term impact of initial surgical and medical therapy on papillary and follicular thyroid cancer. The American journal of medicine. 1994 Nov 1;97(5):418-28.

Ghosh S, Naftalin J, Imrie R, Hoo WL. Natural history of uterine fibroids: a radiological perspective. Current obstetrics and gynecology reports. 2018 Sep;7(3):117-21.

Sommer EM, Balkwill A, Reeves G, Green J, Beral DV, Coffey K. Effects of obesity and hormone therapy on surgically-confirmed fibroids in postmenopausal women. European journal of epidemiology. 2015 Jun 1;30(6):493-9.

Hormones E, Key TJ, Appleby PN, Reeves GK, Roddam AW, Helzlsouer KJ, Alberg AJ, Rollison DE, Dorgan JF, Brinton LA, Overvad K. Circulating sex hormones and breast cancer risk factors in postmenopausal women: reanalysis of 13 studies. British journal of cancer. 2011 Aug;105(5):709.

Ulin M, Ali M, Chaudhry ZT, Al-Hendy A, Yang Q. Uterine fibroids in menopause and perimenopause. Menopause. 2020 Feb 1;27(2):238-42.

Srinivasan V, Martens MG. Hormone therapy in menopausal women with fibroids: is it safe?. Menopause. 2018 Aug 1;25(8):930-6.

Ghoncheh M, Pournamdar Z, Salehiniya H. Incidence and mortality and epidemiology of breast cancer in the world. Asian Pacific Journal of Cancer Prevention. 2016;17(sup3):43-6.

Heer E, Harper A, Escandor N, Sung H, McCormack V, Fidler-Benaoudia MM. Global burden and trends in premenopausal and postmenopausal breast cancer: a population-based study. The Lancet Global Health. 2020 Aug 1;8(8):e1027-37.

Hsu LH, Chu NM, Kao SH. Estrogen, estrogen receptor and lung cancer. International journal of molecular sciences. 2017 Aug;18(8):1713.

Taxel P, Choksi P, Van Poznak C. The management of osteoporosis in breast cancer survivors. Maturitas. 2012 Dec 1;73(4):275-9.

Kotsopoulos IC, Newton CL, Mould TA. Invasive cervical cancer. Obstetrics, Gynaecology & Reproductive Medicine. 2020 May 4.

Chandavarkar U, Kuperman JM, Muderspach LI, Opper N, Felix JC, Roman L. Endometrial echo complex thickness in postmenopausal endometrial cancer. Gynecologic oncology. 2013 Oct 1;131(1):109-12.

Hinds L, Price J. Menopause, hormone replacement and gynaecological cancers. Menopause international. 2010 Jun;16(2):89-93.

Rotenberg O, Doulaveris G, Fridman D, Renz M, Kaplan J, Xie X, Goldberg GL. Long-term outcome of postmenopausal women with proliferative endometrium on endometrial sampling. American journal of obstetrics and gynecology. 2020 Dec 1;223(6):896-e1.

Saso S, Chatterjee J, Georgiou E, Ditri AM, Smith JR, Ghaem-Maghami S. Endometrial cancer. Bmj. 2011 Jul 6;343.

La Vecchia C. Ovarian cancer: epidemiology and risk factors. European journal of cancer prevention. 2017 Jan 1;26(1):55-62.

Alkatout I, Schubert M, Garbrecht N, Weigel MT, Jonat W, Mundhenke C, Günther V. Vulvar cancer: epidemiology, clinical presentation, and management options. International journal of women's health. 2015;7:305.

Helvaci N, Yildiz BO. Polycystic ovary syndrome and aging: Health implications after menopause. Maturitas. 2020 Sep 1;139:12-9.

Kostakis EK, Gkioni LN, Macut D, Mastorakos G. Androgens in menopausal women: not only polycystic ovary syndrome. Hyperandrogenism in Women. 2019;53:135-61.

Ireland K, Child T. Polycystic ovary syndrome and the postmenopausal woman. British Menopause Society Journal. 2006 Dec 1;12(4):143-8.

Chen JH, Lin KP, Chen YC. Risk factors for dementia. Journal of the Formosan Medical Association. 2009 Oct 1;108(10):754-64.

Henderson VW. Oestrogens and dementia. InNovartis Foundation Symposium 2000 Aug 22 (pp. 254-273). Chichester; New York; John Wiley; 1999.

Geerlings MI, Ruitenberg A, Witteman JC, van Swieten JC, Hofman A, van Duijn CM, Breteler MM, Launer LJ. Reproductive period and risk of dementia in postmenopausal women. Jama. 2001 Mar 21;285(11):1475-81.

Büchtemann D, Luppa M, Bramesfeld A, Riedel-Heller S. Incidence of late-life depression: a systematic review. Journal of affective disorders. 2012 Dec 15;142(1-3):172-9.

Thenmozhi S. A study on psychological impact of menopause in Indian working women. Indian Journal of Health & Wellbeing. 2014 Dec 1;5(12).

Muharam R, Setiawan MW, Ikhsan M, Rizkinya HE, Sumapraja K. Depression and its link to other symptoms in menopausal transition. Middle East Fertility Society Journal. 2018 Mar 1;23(1):27-30.

World Health Organization, WHOQOL-BREF: Introduction, Administration, Scoring and Generic Version of Te Assessment: Field Trial Version, December 1996, https://www.who.int/ mental health/media/en/76.pdf.

Greendale GA, Gold EB. Lifestyle factors: are they related to vasomotor symptoms and do they modify the effectiveness or side effects of hormone therapy?. The American Journal of Medicine. 2005 Dec 19;118(12):148-54.

Rathnayake N, Lenora J, Alwis G, Lekamwasam S. Prevalence and severity of menopausal symptoms and the quality of life in middle-aged women: a study from Sri Lanka. Nursing Research and Practice. 2019 Jul 1;2019.

World Health Organization. World Health Organization Preamble to the Constitution of the World Health Organization, 1946.

Schneider HP, Birkhäuser M. Quality of life in climacteric women. Climacteric. 2017 May 4;20(3):187-94.

Chattha R, Kulkarni R, Nagarathna R, Nagendra HR. Factor analysis of Greene's Climacteric Scale for Indian women. Maturitas. 2008 Jan 20;59(1):22-7.

Sierra B, Hidalgo LA, Chedraui PA. Measuring climacteric symptoms in an Ecuadorian population with the Greene Climacteric Scale. Maturitas. 2005 Jul 16;51(3):236-45.

Girod I, Keininger DL, de la Loge C, Hunter M. Presentation of the 23-Item Women's Health Questionnaire (WHQ): Scoring and Interpretation Issues. Quality of Life Research. 2000 Mar 1:303-.

SCHNEIDER HP. Issues relating to quality of life in postmenopausal women and their measurement. InTreatment of the postmenopausal woman 2007 Jan 1 (pp. 639-654). Academic Press.

Williams RE, Levine KB, Kalilani L, Lewis J, Clark RV. Menopause-specific questionnaire assessment in US population-based study shows negative impact on health-related quality of life. Maturitas. 2009 Feb 20;62(2):153-9.

Perz JM. Development of the menopause symptom list: a factor analytic study of menopause associated symptoms. Women & health. 1997 Jun 30;25(1):53-69.

Moravcová M, Ježek S, Mareš J, Vachková E. ?eská verze dotazníku Menopause Rating Scale-p?edb?žné sd?lení. Kontakt. 2014 Jun 23;16(2):e94-101.

Heinemann K, Ruebig A, Potthoff P, Schneider HP, Strelow F, Heinemann LA. The Menopause Rating Scale (MRS) scale: a methodological review. Health and Quality of life Outcomes. 2004 Dec;2(1):1-8.

Schultz-Zehden B. Frauengesundheit in und nach den Wechseljahren. Verlag Kempkes, Gladenbach. 1998.

Published

2021-07-06
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Timmana, V. G., G. Mattapalli, E. Gujju, and P. Boddu. “Understanding Menopause-Postmenopausal Complications, Management and Quality of Life”. International Journal of Pharmaceutics and Drug Analysis, vol. 9, no. 2, July 2021, pp. 109-25, doi:10.47957/ijpda.v9i2.473.

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