Formulation and Invitro evaluation of immediate release tablets containing febuxostat

Authors

  • Srikumar Billa Department of Pharmaceutics, M.L. College of Pharmacy, S. Konda-523101.
  • Saibabu Ch Head , Department of Pharmaceutics, M.L. College of Pharmacy, S. Konda-523101.
  • T.Malyadri Assistant professor, , Department of Pharmaceutics, M.L. College of Pharmacy, S. Konda-523101.

DOI:

https://doi.org/10.47957/ijpda.v9i2.466

Keywords:

Febuxostat, CCS, Lycoat, Crospovidone

Abstract

In the present research work, Febuxostat Immediate Release Tablet was prepared by direct compression method using varying concentrations of Lycoat, Crospovidone& Croscarmellose sodium as disintegrants. The formulations prepared were evaluated for precompression& post-compression parameters. From the drug excipient compatibility studies, we observe that there are no interactions between the pure drug (Febuxostat) and optimized formulation (Febuxostat+ excipients) which indicates there are no physical changes. Post compression parameters were found to be within the limits. Among the formulation prepared the tablet containing 12mg of CCS shows 98.13% of the drug release within 45 min & follows first-order kinetics.

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Published

2021-07-06
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How to Cite

Billa, S., S. Ch, and M. T. “Formulation and Invitro Evaluation of Immediate Release Tablets Containing Febuxostat”. International Journal of Pharmaceutics and Drug Analysis, vol. 9, no. 2, July 2021, pp. 93-101, doi:10.47957/ijpda.v9i2.466.

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