Novel phytotherapy for tinea versicolor by extracting zingiber wightianum thwaites
Keywords:Malassezia furfur, Zingiber wightianum Thwaties, Anti-fungal, Tinea versicolor
Herbal medicines are gaining more interest both in terms of medicinal and economic benefits and they are getting more patient compliance due to its fewer side effects as compared to allopathic medicines. The present research was aimed at phytochemical screening and antifungal evaluation of rhizomic extract of Zingiber wightianum Thwaites belonging to Zingiberaceae family. The rhizomes were subjected for Soxhlet extraction and the preliminary phytochemical screening of this extract proved the presence of alkaloids, carbohydrates, tannins, flavonoids, saponins, phenols. Subsequently, these extracts were evaluated for antifungal activity and minimum inhibitory concentration was determined. Hence revealed the potential to treat a fungal infection Tinea versicolor, caused by fungus Malassezia furfur. This investigation was also undertaken with a view to formulate and evaluate the herbal gel using Zingiber wightianum rhizomic extract. Thus, the overall studies concluded that the rhizomic extract of Zingiber wightianum Thwaites and its formulation would be a breakthrough in the field of modern antifungal drug.
Hu SW, Bigby M. Pityriasis versicolor: a systematic review of interventions. Archives of dermatology. 2010 Oct 1;146(10):1132-40
Ghosh SK, Dey SK, Saha I, Barbhuiya JN, Ghosh A, Roy AK. Pityriasis versicolor: A clinicomycological and epidemiological study from a tertiary care hospital. Indian journal of dermatology. 2008;53(4):182.
Kallini JR, Riaz F, Khachemoune A. Tinea versicolor in dark?skinned individuals. International journal of dermatology. 2014 Feb;53(2):137-41.
Gupta AK, Batra R, Bluhm R, Faergemann J. Pityriasis versicolor. Dermatologic clinics. 2003 Jul;21(3):413-29.
Saunders CW, Scheynius A, Heitman J. Malassezia fungi are specialized to live on skin and associated with dandruff, eczema, and other skin diseases. PLoS pathogens. 2012 Jun;8(6).
CHEN TA, HILL PB. The biology of Malassezia organisms and their ability to induce immune responses and skin disease. Veterinary dermatology. 2005 Feb;16(1):4-26.
Guého E, Boekhout T, Ashbee HR, Guillot J, Van Belkum A, Faergemann J. The role of Malassezia species in the ecology of human skin and as pathogens. Medical mycology. 1998 Aug 1;36(1):220-9.
Vijayakumar R, Muthukumar C, Kumar T, Saravanamuthu R. Characterization of Malassezia Furfur and its control by using plant extracts. Indian J Dermatol 2006;51: 145-8
Scorzoni L, Benaducci T, Almeida AM, Silva DH, Bolzani VD, Gianinni MJ. The use of standard methodology for determination of antifungal activity of natural products against medical yeasts Candida sp and Cryptococcus sp. Brazilian Journal of Microbiology. 2007 Sep;38(3):391-7.
Singh J, Zaman M, Gupta AK. Evaluation of microdilution and disk diffusion methods for antifungal susceptibility testing of dermatophytes. Medical mycology. 2007 Nov 1;45(7):595-602.
Dantas MG, Reis SA, Damasceno CM, Rolim LA, Rolim-Neto PJ, Carvalho FO, Quintans-Junior LJ, Almeida JR. Development and evaluation of stability of a gel formulation containing the monoterpene borneol. The Scientific World Journal. 2016;2016.
Misal G, Dixit G, Gulkari V. Formulation and evaluation of herbal gel.
Un Nabi SA, Sheraz MA, Ahmed S, Mustaan N, Ahmad I. Pharmaceutical Gels: A Review. RADS Journal of Pharmacy and Pharmaceutical Sciences. 2016 Jun 19;4(1):40-8.
Bhuiyan MNI, Chowdhury JU, Begum J. Chemical investigation of the leaf and rhizome essential oils of Zingiber zerumbet (L.) Smith from Bangladesh. Bangladesh J Pharmacol. 2009;4(1):9–12.
Singh C, Chanu S, Swapana N, Cantrell C, Ross S. Chemical Composition and Biological Activity of the essential oil of the Rhizome of Zingiber zerumbet(L) Smith. Journal of Pharmacognosy and Phytochemistry 2014;3(3):130-133.
Tushar, Basak S, Sarma GC, Rangan L. Ethnomedical uses of Zingiberaceous plants of Northeast India. J Ethnopharmacol. 2010; 132:286–296.
Pingili M, Vanga S, Raparla R. Antifungal activity of plant extracts against dandruff causing organism Malassezia furfur. International journal of Bioassays.2016;5(11):5047-5049.
Bhargava S, Dhabhai K, Batra A, Sharma A, Malhotra B. Zingiber officinale: Chemical and phytochemical screening and evaluation of its antimicrobial activities. Journal of chemical and pharmaceutical research. 2012;4(1):360-4.
Kusuma IW, Kuspradini H, Arung ET, Aryani F, Min YH, Kim JS, Kim YU. Biological activity and phytochemical analysis of three Indonesian medicinal plants, Murraya koenigii, Syzygium polyanthum and Zingiber purpurea. Journal of Acupuncture and Meridian Studies. 2011 Mar 1;4(1):75-9.
Isobel Adams., Stanly S., Davis. “The formulation and sterilization of a surgical lubricant gel based on carboxypolymethylene”, J. Pharm. Pharmacol 1973; 25:640- 646.
Chowdary KPR., Kumar PA., “Formulation and evaluation of topical drug delivery systems of ciprofloxacin”, Ind. J. Pharm. Sci., 1996 Mar; 58(2):47-50.
Rhimi W, Ben Salem I, Immediato D, Saidi M, Boulila A, Cafarchia C. Chemical composition, antibacterial and antifungal activities of crude Dittrichia viscosa (L.) greuter leaf extracts. Molecules. 2017 Jul;22(7):942.
Pizzolitto RP, Barberis CL, Dambolena JS, Herrera JM, Zunino MP, Magnoli CE, Rubinstein HR, Zygadlo JA, Dalcero AM. Inhibitory effect of natural phenolic compounds on Aspergillus parasiticus growth. Journal of Chemistry. 2015;2015.
Blessy George, Dr. R. Dhivya. 36-36 Screening and Antifungal Activity of Solvent Extracts of Averrhoa bilimbi Leaves against Aspergillus niger and Rhizopus stolonifer, Vol.4; Issue: 2; International Journal of Science and Healthcare Research; April-June 2019;29-37.
Basha BN, Prakasam K, Goli D. Formulation and evaluation of gel containing fluconazole-antifungal agent. Int J Drug Dev Res. 2011
Kusum kaushik, shweta agarwal. The role of herbal antifungal agents for the management of fungal diseases: a systematic review. Asian j pharm clin res [internet]. 2019may28 [cited 2020feb.8];12(7):34-37.
Seyed Mojtaba Moosavi and Sussan Ghassabian. Linearity of Calibration Curves for Analytical Methods: A Review of Criteria for Assessment of Method Reliability, Volume 3; Issue 2 ed.: international Journal of Botany Studies; 2018;67-72
Patel J, Patel B, Banwait H, Parmar K, Patel M. Formulation and evaluation of topical aceclofenac gel using different gelling agent. Int J Drug Dev Res. 2011 Jan;3(1):156-64.
Bankar AM, Dole MN. Formulation and evaluation of herbal antimicrobial gel containing musa acuminata leaves extract. Journal of Pharmacognosy and Phytochemistry. 2016 Jan 1;5(1):1.
Lavanya J, Selvam S, Priya M, Jacintha P, Aradana M. Antioxidant and antimicrobial activity of selected medicinal plants against human oral pathogens. International Journal of Pharmacology and Pharmaceutical Science, 2016, 8-9.
Ayodele OA, Akinyosoye FA, Arotupin DJ, Owoyemi OO, Oyindamola AB. Phytochemical screening and antifungal activities of Zingiber officinale (Roscoe) on mycotoxigenic fungi associated with the deterioration of Pennisetum glaucum grains. Journal of Advances in Microbiology. 2018 Nov 21:1-1.
El-Baroty GS, El-Baky HA, Farag RS, Saleh MA. Characterization of antioxidant and antimicrobial compounds of cinnamon and ginger essential oils. African Journal of Biochemistry Research. 2010 Jun;4(6):167-74.
Kader G, Nikkon F, Rashid M, Yeasmin T. Antimicrobial Activity of Rhizome Extract of Zingiber zerumbet Linn. Asian Pacific Journal of Tropical Biomedicine 2011;1(5):409-412.
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