Osmotic release tablets formulation and evaluationof ace inhibitor molecule


  • Prachetha Kolli Scientist, Microgen Health Inc, 14225,Sullyfield Cir Suite E, Chantilly, VA, USA-2015
  • Sudhakar Kancharla Director Clinical Laboratory, Devansh Lab Werks,234, Aquarius Drive, Homewood, Alabama, USA-3520
  • Dr.K.Venkata Gopaiah Associate Professor, St. Mary’s College of Pharmacy, Chebrolu, Guntur-A.P-522 212-India






In the present study the Suitable analytical methods were developed for the drug using UV – visible spectrophotometer. From the Preformulation study and thermal analysis (DSC), the interference was verified and found that the drug did not interfere with the excipient use.Core tablet was successfully prepared by wet granulation using Polyethylene oxide WSR N80, Mannitol 25C, silicon dioxide, magnesium stearate, Polyethylene WSR 303, sodium chloride, hydroxypropyl methylcellulose (HPMC E5), Iron oxide red. Isopropyl cellulose was found to be suitable granulating fluid for binder.Formulation of the drug coating was optimized by using 22 factorial design of experiment.The coated tablets were evaluated for various physicochemical parameter. About  79 to 95% of drug was released from the formulation A-E in 24 hr in 6.8 phosphate buffer.The in vitro drug release data were plotted in zero order kinetics and optimized batch were evaluated on the basis of regression coefficient.The in-vitro drug release from the optimized formulation in the dissertation was directly proportional to the concentration of plasticizer and concentration of cellulose acetate.The manufacturing procedure was standardized and reproducible


Download data is not yet available.


Vyas SP, Khar RK, Controlled drug delivery: Concepts and advances, 1st ed. Delhi: Vallabhprakashan; 2002.

Verma RK, Garg S. Current status of drug delivery technologies and future directions. Pharma Techno 2001;25(2):1-13.

Thombare AG, DeNoto AR, Gibbes DC. Delivery of glipizide from assymetric membrane capsule using encapsulated excipients. J Control Rel 1999;333-41.

Robinson JR, Lee Vh. Controlled drug delivery: fundamentals and applications. 2nd ed. Revised and expanded. New york: Marcel dekker INC; 1987.

Hoffman A. Pharmacodynamic aspects of sustained release preparations. Adv Drug Del Rev 1988; 33: 185-99.

Jain NK. Controlled and novel drug delivery. 1st ed. New Delhi: CBS Publishers; 2002.

Ritschel WA. Biopharmaceutics and pharmacokinetics aspects in the design of controlled release peroral drug delivery systems. Drug Del Ind Pharm 1989; 15: 1073-103.

Banker SG, Rhodes TC. Modern Pharmaceutics. 2nd ed. Revised and expanded. New York: Marcel Dekker INC; 1990.

Remington. The science and practice of pharmacy. 20thed. New York: Lippincott Williams and Wilkins; 2000.

Xiaoling Li, Bhaskara R Jasti. Design of controlled release drug delivery systems. McGraw-Hill;2006.

Thombare AG, AppelLE,Chidlaw MB, Daugherity PD, Dumont FL. Evans LA, et al. Osmotic drug delivery using swellable core technology. J Control Rel 2004; 94:75-89.

Lachman L, Liberman HA, Kanig JL. Theory and practice of industrial pharmacy. 3rd ed. Bombay: Varghese house;1987.

Subramanyam CVS. Essential of physical pharmacy. 1sted Delhi: VallabhPrakashan; 2003.

NB Khavare, Fatima S Dasankoppa, NG Najundaswamy. A review on key parameters and Components in Designing of osmotic controlled oral drug delivery systems. Indian Journal of Novel Drug Delivery 2(4), Oct-Dec 2010; 122-131.

Giancarlo S, Richard WD. Osmotic drug delivery: a review of the patent literature. J control Rel 1995; 35: 1-21.

Theeuwes F. Elementary osmotic pump. J Pharmasci 1975;64(12): 1987-91.

Nuttan S, sansee P, Pichet L, Ampol M. design of salbutamol EOP tablets from pharmacokinetic parameter. Pharm DevTechnol 2003; 8(2): 135-42.

Rastogi SK, Vaya N, Mishra B. Osmotic pump: a novel concept in rate controlled oral drug delivery. Eastern pharmacist 1995:79-82.

Prakashan D, singh P, Kanauja P, Vyas SP. Effect of Hydrophillic polymers on the release of Diltiazem hydrochloride from elementary osmotic pumps. Int J pharm 2330; 259: 173-9.

Vyas SP, Guleria R, Singh R. Development and in-vitro characterization of elementary osmotic pump bearing ciprofloxacin HCl. The Eastern Pharmacist 1995;38(447):133-5.

Verma RK, Krishna DM, Garg S. Formulation aspects in development of osmotically controlled drug delivery systems J Control Release 2002; 79: 7-27.

Jain NK. Advances in controlled and novel drug delivery. 1sted. New Delhi; CBS Publishers; 2003.

Verma RK, Mishra B, Garg S. Osmotically controlled oral drug delivery. Drug DelInd Pharm 2000; 26(7): 695-708.

Longxioa L, Jeong K, Gilsin K, Bong L, John MR, Hai BL. Nifedipine controlled delivery by sandwiched osmotic tablet system. J control Release 2000; 68: 145-56.

Peter S,Peter K. A new multiparticulatedelayed release system Part I; dissolution properties and release mechanism. J Control Rel 1997; 47: 191-9.

Peter S, Ingunn T, Peter K. A new multiparticulate delayed release system Part II: coating formulation and properties of free films. J control Rel 1997; 47: 191-9.

Ritesh B. patel, H.R. patel, G.N. Patel, R.P. patel, M.M. Patel. Development of osmotically controlled drug delivery system by inclusion complex with HP-?-CD of glipizide: Optimization of formulation using response surface methodology. Asian Journal of Pharmaceutical sciences 2010,(2): 74-86.

BsaniGavaskar, Subashvijayakumar, DilipDodda. Effect of tablet formulation variables on tramadol HCl elementary osmotic pump tablet. International Journal of drug development & research. Oct-dec 2010 2(4).

Javadshokri, ParinazAhmadi, ParisaRashidi, MahbobehShahsavri, Ali Rajabi-Siahboomi, Ali Nokhodch. Swellable elementary osmotic pump (SEOP): An effective device for delivery of poorly water-soluble drugs. European journal of Pharmaceutics and biopharmaceutics 68(2008) 289-297.

Mehramizi A, AsgariMonfared E, Pourfarzib M, Bayati KH, Dorkoosh F.A, Rafiee-Tehrani M. Influence of ?-cyclodextrincomplexation on lovastatin release from osmotic pump tablets (OPT). DARU Vol.15, no. 2 2007.

Lu Xu, Sanming Li, Hisakazusunada. Preparation and evaluation in vitro and in vivo captopril elementary osmotic pump tablets. Asian Journal of Pharmaceutical sciences 2006, 1 (3-4): 236-245.

Mishra B, Srivastava S, Singh S, Sankar C, Oral osmotic pumps for poorly water soluble drug-rofecoxib: formulation development perspective. Ind Drugs 2006; 43(7): 553-61.

Ouyang Defang, NieShufang, Li Wei. In Vitro and in vivo Evaluation of Two extended release preparations of combination Metformin anfGlipizide. Drug Development and Industrial pharmacy, 31: 677-685,2005.

Prabakaran D, Singh P, Kanauja P, Vyas SP. Effect of hydrophilic polymers on the release of Diltiazem hydrochloride from Elementary osmtic pumps. Int J Pharm 2003;259: 173-9.

NurtenOzdemir, Jfilidesachin. Design of a controlled release osmotic pump system of ibuprofen. Int J of pharmaceutics158(1997) 91-97.

Avinashsingh, R. K. Mohammed Mutahar, Rakhee B Jain, Patel Pinkesh. An approach to develop the controlled drug delivery system for Glipizide. Der Pharmacia letter,2011, 3(1): 262-275.

B. Prakashrao M. Geetha, N. Purushothama,,Utpalsanki. Optimization and Development of swellable Controlled porosity osmotic pump Tablet for Theophylline. Tropical Journal of pharmaceutical research, 2009; 8(3) 247-255.

Jung soo Park, Jun Hyun Shin, Dong Hun Lee,Moon Suk Kim, John M. Rhee, Hai Bang Lee, Gilson Khang,Asqqeeze-type osmotic tablet for controlled delivery of Nifedipine. J. Biomater. Sci. Polymer edn; (2008): 19(1); 31-45.

Longxioa L, Xianging X. Preparation of Bilayer-core osmotic pump tablet by coating the intended core tablet. Int J Pharm 2008;352:225-30.

Kumar P, Singh S, Miahra B. Drug delivery system of Ranitidine hydrochloride based on osmotic technology: Development and evaluation. Current Drug Delivery 20085: 332-42.


230 Views | 146 Downloads

How to Cite

Kolli, P., S. Kancharla, and D. . Gopaiah. “Osmotic Release Tablets Formulation and Evaluationof Ace Inhibitor Molecule”. International Journal of Pharmaceutics and Drug Analysis, vol. 9, no. 1, Mar. 2021, pp. 24-35, doi:10.47957/ijpda.v9i1.455.



Research Articles
Share |