Overview of various medicinal plants having potent activity against ulcers
Keywords:peptic ulcer, side effects, drug interaction
A peptic ulcer is the most widely recognized gastrointestinal problem in clinical practice. Various medications including proton pump inhibitors and H2 receptor antagonists are accessible for the treatment of peptic ulcers. However, these medications have demonstrated the frequency of side effects and drug interaction. Medicinal plants give a successful and more secure route in the treatment of peptic ulcers. Numerous therapeutic plants are shown to have potential antiulcer activity. Various methods like pylorus ligation method, indomethacin-induced gastric ulcer, acetic acid-induced ulcer model, ethanol-induced gastric ulcer were used to induce ulcer. The present paper is an attempt to present a comprehensive review of different methods for inducing ulcers, various plant parts, and their solvent extracts having a beneficial antiulcer activity.
Chan FK, Graham DY. Prevention of non?steroidal anti?inflammatory drug gastrointestinal complications–review and recommendations based on risk assessment. Alimentary pharmacology & therapeutics. 2004 May; 19  :1051-61.
Bhowmik D, Chiranjib TK, Pankaj KS. Recent trends of treatment and medication peptic ulcerative disorder. Int J Pharm Tech Research. 2010;2:970-80.
Vyawahare N, Deshmukh V, Gadkari M, Kagathara V. Plants with antiulcer activity. Pharmacognosy Reviews. 2009;3:118.
Søreide K, Thorsen K, Harrison EM, Bingener J, Møller MH, Ohene-Yeboah M, Søreide JA. Perforated peptic ulcer. The Lancet. 2015 Sep 26;386:1288-98.
Siddique O, Ovalle A, Siddique AS, Moss SF. Helicobacter pylori infection: an update for the internist in the age of increasing global antibiotic resistance. The American journal of medicine. 2018 May 1;131:473-9.
Zaki M, Coudron PE, McCuen RW, Harrington L, Chu S, Schubert ML. H. pylori acutely inhibits gastric secretion by activating CGRP sensory neurons coupled to stimulation of somatostatin and inhibition of histamine secretion. American Journal of Physiology-Gastrointestinal and Liver Physiology. 2013 Apr 15;304:G715-22.
Moss SF, Calam J, Legon S, Bishop AE, Polak JM. Effect of Helicobacter pylori on gastric somatostatin in duodenal ulcer disease. The Lancet. 1992 Oct 17;340:930-2.
Zakaria ZA, Hisam EA, Rofiee MS, Norhafizah M, Somchit MN, Teh LK, Salleh MZ. In vivo antiulcer activity of the aqueous extract of Bauhinia purpurea leaf. Journal of ethnopharmacology. 2011 Sep 2;137:1047-54.
El-Dien RT, Maher SA, Abdelmohsen UR, AboulMagd AM, Fouad MA, Kamel MS. Antiulcer secondary metabolites from Elaeocarpusgrandis, family Elaeocarpaceae, supported by in silico studies. RSC Advances. 2020;10:34788-99.
Mekonnen AN, AsradeAtnafie S, Wahab Atta MA. Evaluation of Antiulcer Activity of 80% Methanol Extract and Solvent Fractions of the Root of Croton macrostachyusHocsht: Ex Del.[Euphorbiaceae] in Rodents. Evidence-Based Complementary and Alternative Medicine. 2020 Apr 9;2020.
Yismaw YE, Abdelwuhab M, Ambikar DB, Yismaw AE, Derebe D, Melkam W. Phytochemical and Antiulcer Activity Screening of Seed Extract of Cordiaafricana Lam [Boraginaceae] in Pyloric Ligated Rats. Clinical Pharmacology: Advances and Applications. 2020;12:67.
Maheswari B, Devi PR, Ajith K, VedPrakash P, Gayatri KS. Evaluation of Antiulcer Activity of Ethanol Extract of Leaves of Lactucasativa. Journal of Drug Delivery and Therapeutics. 2020 Jul 22;10:196-9.
Panchawat S, Pradhan J. Comparative Evaluation of Antiulcer Activity of Ficus religiosa [Stem Bark] Extracts Prepared by Different Methods of Extraction. Current Traditional Medicine. 2020 Dec 1;6:351-9.
Verma P, Paswan SK, Vishwakarma VK, Saxena P, Rao CV, Shrivastva S. Evaluation of the Antiulcer Activity of Ethanolic Leave Extracts of Saracaindica against Ethanol, Pylorus Ligature and Indomethacin Induced Ulcer in Albino Rats. Current Bioactive Compounds. 2020 Oct 1;16:1191-6.
Manjunatha E, Vedigounder M, Geetha KM, Nandeesh R, Ahmed SM. Antioxidant and Antiulcer activity of Ziziphus rugosa Lam. bark. Research Journal of Pharmacy and Technology. 2020 Oct 1;13:4720-4.
Zewdu WS, Aragaw TJ. Evaluation of the Anti-Ulcer Activity of Hydromethanolic Crude Extract and Solvent Fractions of the Root of Rumexnepalensis in Rats. Journal of Experimental Pharmacology. 2020;12:325.
Bose S, Majumdar M. Preclinical Evaluation of Antiulcer activity of hydroalcoholic extracts of Macrotyloma uniflorum seed. Research Journal of Pharmacy and Technology. 2020;13:853-6.
Chavan GM, Ranalkar MD, Bagul SK, Patil SG, Patil SA, Pawar SP. Evaluation of Anti-ulcer Activity of leaves of AlstoniaScholaris [L] R Br by using Pylorus Ligation Method. Journal of Seybold Report ISSN NO.;1533:9211.
Ebada SS, Al-Jawabri NA, Youssef FS, Albohy A, Sa’ed MA, Disi AM, Proksch P. In vivo antiulcer activity, phytochemical exploration, and molecular modelling of the polyphenolic-rich fraction of Crepis sancta extract. Inflammopharmacology. 2020 Feb 1;28:321-31.
Shirode DS, Powar P, Jain BB, Agarwal A. Antiulcer effect of Blumealacera against Gastric ulcers in rats. Research Journal of Pharmacy and Technology. 2020 Jul 1;13:3340-2.
Kumar CP, Prathap P, Kazmi MH, Darshanala A. Evaluation of Antiulcer Activity by Using Flower Extract of Ctenolepisgarcini in Aspirin Induced Rats.
Tejaswi JK. Determination of Anti Mitotic and Anti-Ulcer Activity of Ruelliatuberosa. June 2020; 8:1027-30
Elshamy AI, Farrag AR, Ayoub IM, Mahdy KA, Taher RF, Gendy AE, Mohamed TA, Al-Rejaie SS, Ei-Amier YA, Abd-EIGawad AM, Farag MA. UPLC-qTOF-MS phytochemical profile and antiulcer potential of CyperusconglomeratusRottb. alcoholic extract. Molecules. 2020 Jan;25:4234.
Abubakar I, Muhammad HY, Shuaibu YB, Abubakar MG. Anti-ulcer activity of methanol extract of the leaves of Hannoaklaineana in rats.
Njoku UO, Umeh CG, Ogugofor MO. Anti-ulcerogenic Activity of Methanol Fraction of Hibiscus asper Leaves in Albino Rats. African Journal of Biomedical Research. 2020 Aug 5;23:267-72.
Karaoglan ES, Bayir Y, Albayrak A, Toktay E, Ozgen U, Kazaz C, Kahramanlar A, Cadirci E. Isolation of Major Compounds and Gastroprotective Activity of AlchemillaCaucasica on Indomethacin Induced Gastric Ulcers in Rats. The Eurasian Journal of Medicine. 2020 Oct;52:249.
Venu K. Anti-ulcer Potential of Aqueous and Ethanolic Bark Extracts of “Saracaindica” Using Different Screening Models. Asian Journal of Pharmaceutics [AJP]: Free full text articles from Asian J Pharm. 2020 Jul 22;14.
Makelele FB, Mukweke NL, Chasinge T, Murhula PH, Kadima JN. Antiulcer effect of Perseaamericana seed against alcohol-induced peptic ulcer in guinea pig. Journal of Pharmacognosy and Phytochemistry. 2020;9:1244-9.
Sofi SH, Nuraddin SM, Amin ZA, Al-Bustany HA, Nadir MQ. Gastroprotective activity of Hypericumperforatum extract in ethanol-induced gastric mucosal injury in Wistar rats: A possible involvement of H+/K+ ATPase ? inhibition. Heliyon. 2020 Oct 1;6:e05249.
Ofusori AE, Moodley R, Jonnalagadda SB. Antiulcerogenic effects of Celosia trigyna plant extracts on ethanol-induced gastric ulcer in adult Wistar rats. Journal of traditional and complementary medicine. 2020 Nov 1;10:586-93.
Brito SA, de Almeida CL, de Santana TI, da Silva Oliveira AR, do NascimentoFigueiredo JC, Souza IT, de Almeida LL, da Silva MV, Borges AS, de Medeiros JW, da Costa Silva Neto J. Antiulcer Activity and Potential Mechanism of Action of the Leaves of Spondiasmombin L. Oxidative medicine and cellular longevity. 2018 Jan 1;2018.
Ugwah MO, Ugwah-Oguejiofor CJ, Etuk EU, Bello SO, Aliero AA. Evaluation of the antiulcer activity of the aqueous stem bark extract of Balanitesaegyptiaca L Delile in Wistar rats. Journal of ethnopharmacology. 2019 Jul 15;239:111931.
Mostofa R, Ahmed S, Begum MM, Rahman MS, Begum T, Ahmed SU, Tuhin RH, Das M, Hossain A, Sharma M, Begum R. Evaluation of anti-inflammatory and gastric anti-ulcer activity of Phyllanthusniruri L.[Euphorbiaceae] leaves in experimental rats. BMC complementary and alternative medicine. 2017 Dec 1;17:267.
Pradeepkumar B, Bhavyamadhuri CP, Padmanabhareddy Y, Veerabhadrappa KV, Narayana G, Haranath C, Somasekharreddy K, Sudheer A. Evaluation of antiulcer activity of Peltophorumpterocarpum. Journal of Clinical and Diagnostic Research: Jcdr. 2017 Jun;11:FF01.
Sahoo SK, Sahoo HB, Priyadarshini D, Soundarya G, Kumar CK, Rani KU. Antiulcer activity of ethanolic extract of Salvadoraindica [W.] leaves on albino rats. Journal of clinical and diagnostic research: JCDR. 2016 Sep;10:FF07.
Abebaw M, Mishra B, Gelayee DA. Evaluation of anti-ulcer activity of the leaf extract of OsyrisquadripartitaDecne.[Santalaceae] in rats. Journal of experimental pharmacology. 2017;9:1.
Vema BK, Mukerjee A, Verma A, Bhushan S. Preclinical screening of Antiulcer activity of Asparagus racemosus extract on phenylbutazone induced ulceration in experimental animals. Journal of Medicinal Plants. 2017;5:348-52.
Farrag AR, Abdallah HM, Khattab AR, Elshamy AI, El Gendy AE, Mohamed TA, Farag MA, Efferth T, Hegazy ME. Antiulcer activity of Cyperusalternifolius in relation to its UPLC-MS metabolite fingerprint: a mechanistic study. Phytomedicine. 2019 Sep 1;62:152970.
Ulser T. Antiulcer activity of Musa paradisiaca [banana] tepal and skin extracts in ulcer induced albino mice. Malaysian Journal of Analytical Sciences. 2016;20:1203-16.
Palle S, Kanakalatha A, Kavitha CN. Gastroprotective and antiulcer effects of Celastruspaniculatusseed oil against several gastric ulcer models in rats. Journal of dietary supplements. 2018 Jul 4;15:373-85.
Mohan CM. Antidiarrheal and antiulcer activity of StachytarphetaurticifoliaSalisb [sims] in Wistar rats. International Journal of Green Pharmacy [IJGP]. 2019 May 24;13.
How to Cite
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Most read articles by the same author(s)
- Shilpa V, Rupesh Kumar M, Harshitha H S, Chinthana H B, B Ramesh, Pharmacological and phytochemical evaluation of Chromolaena odorata , International Journal of Pharmaceutics and Drug Analysis: Volume-8, Issue-6, June-2020
- Abhishek K, Rupesh Kumar M, Shamal Badhusha PA, Sanjay K Gowda, Angitha Ajay, Blainy Baby, Ethanobotonical and biological activities of Carica papaya Linn: A review , International Journal of Pharmaceutics and Drug Analysis: Volume-8, Issue-8, August-2020
- Shamal Badhusha PA, Rupesh Kumar M, Angitha Ajay, Blainy Baby, Abhishek K, Sanjay K Gowda, B Ramesh, Traditional uses, Phytochemistry and Ethanopharmacology of Ruta graveolens Linn: A review , International Journal of Pharmaceutics and Drug Analysis: Volume-8, Issue-3, March-2020
- Sanjay K Gowda, Rupesh Kumar M, Abhishek K, Shamal Badhusha P A, Blainy Baby, B Ramesh, Moringa oleifera: A Nutrional tree with immense medicinal value-Ethonobotanical and Pharmacological review , International Journal of Pharmaceutics and Drug Analysis: Volume-8, Issue-1, January-2020
- Harshitha H S, Rupesh Kumar M, Shilpa V, B Ramesh, Comprehensive review on various medicinal plants having potent anti-diabetic activity , International Journal of Pharmaceutics and Drug Analysis: Volume-8, Issue-5, May-2020
- Blainy Baby, Rupesh Kumar M, Angitha Ajay, Shamal Badhusha PA, Abhishek K , Sanjay K Gowda, B Ramesh, A Short Review Of Tectona Grandis – Ethanopharmacological Activity , International Journal of Pharmaceutics and Drug Analysis: Volume-8, Issue-4, April-2020
- Angitha Ajay, Rupesh Kumar M, Shamal Badhusha PA, Abhishek K, Sanjay K Gowda, B Ramesh, Pharmacological Importance of Chromolaena odorata: a review , International Journal of Pharmaceutics and Drug Analysis: Volume-9, Issue-1, 2021 (January-March)