Synthesis, characterization and anti-bacterial activity of schiff bases of sulphanilamide derivatives

Abstract

A Schiff base (azomethine) is named after its inventor, Hugo Schiff and it is a functional group that contains a carbon-nitrogen double bond with the nitrogen atom connected to an aryl or alkyl group but not hydrogen. Schiff bases have the general formula of R₁R₂C=NR₃, where R₃ is an aryl or alkyl group that makes the Schiff base a stable imine. Schiff bases can be synthesized from a reaction of an aromatic amine and a carbonyl compound by a nucleophilic addition forming a hemiaminal, followed by dehydration to generate an imine. The scheme includes Sulphanilamide react with various aromatic aldehydes to give Schiff base derivatives. (SFB-1 to SFB-5). All the synthesized compounds were purified by appropriate solvents, identified and characterized by TLC, Melting Point, IR spectroscopy. In the present study all synthesized compounds tested for anti bacterial activity and have shown significant activity when compared with standard drug Streptomycin. But as the biological and pharmacological screening conducted were preliminary.