• Konda Ravi Kumar Department of Pharmaceutical Chemistry, Hindu college of Pharmacy, Guntur.
  • N. Hasya Harshitha Department of Pharmaceutical Chemistry, Hindu college of Pharmacy, Guntur.
  • B. Sai Keerthana Department of Pharmaceutical Chemistry, Hindu college of Pharmacy, Guntur.


Sydnone, Mesoionic, Heterocycles, imines, biological activity


Sydnones are mesoionic heterocyclic aromatic compounds. They have been widely studied for some important biological activities like antiviral, antitumor, antimicrobial, anti-inflammatory, anticancer, analgesic, anthelmintic and antihypertensive activities. The aim of the present article is to review the available information on sydnones and the derivatives of sydnones and also a look at the future perspectives. Sydnone can be defined as a five-membered pseudo-aromatic heterocyclic molecule. Classically, 1,2,3-oxadiazole forms the main skeleton of sydnone. The molecule has delocalized balanced positive and negative charges. The five annular atoms share the positive charge and the enolate-like exocyclic oxygen atom bears the negative charge. The hydrogen atom at the position C4 was proved to have acidic and nucleophilic functionalities making the sydnone ring reactive towards electrophilic reagents. These unique chemical features enable sydnones to interact with biomolecules resulting in important therapeutic effects like anticancer, antidiabetic, antimicrobial, antioxidant and anti-inflammatory. Consequently, we aim from the current article to review the available chemical and pharmacological information on sydnone and its derivatives.


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How to Cite

Konda Ravi Kumar, N. Hasya Harshitha, and B. Sai Keerthana. “CHEMISTRY OF MESOIONIC SYDNONES AS VERSATILE HETEROCYCLIC COMPOUNDS”. International Journal of Pharmaceutics and Drug Analysis, Dec. 2019, pp. 88-95,



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