Effect Of Polymers On Metronidazole Anti-Amoebic Tablets On Colon Drug Delivery System.


  • Rajkumar School of Pharmacy, OPJS University. Churu, Rajasthan, India.
  • Md. Majid Iqbal MESCO College of Pharmacy, Hyderabad, Telangana State
  • Tukaram Tadmale Basaveshwara College of Pharmacy, Bidar, Karnataka
  • Rohit Saraswat School of Pharmacy, OPJS University. Churu, Rajasthan, India.


Metronidazole, Chitosan, Pectin Amoebiasis, PVP K-30, Carbopol 934P, Compression Coated Tablets, Colon Drug Delivery System


The aim of the present study is to compare the effect of polymers on colon targeted drug delivery of Metronidazole compression coated tablets by using different polymer ratios of Chitosan and Pectin. Carbopol 934P coating is given for compression coated tablets which makes them able to release the drug at the pH of colonic fluid.Core Tablets of Metronidazole (400 mg) were prepared by using swellable and PH Dependent polymers like Chitosan and pectin in which PVP-K30 is used as Binder. Drug release profile was evaluated in simulated gastric fluid, intestinal fluid and simulated colonic fluid.The results of drug release studies performed according to the USP paddle method by using 0.1N Hcl for 2hrs, pH 7.4 phosphate buffer for 3 hrs and pH 6.8 phosphate buffer up to 24 hrs without using rat caecal content. Compression coated tablets containing chitosan as polymer released 95-99% of Metronidazole in simulated colonic fluid, whereas tablets containing pectin as polymer released 94-99% of Metronidazole. The stability study for prepared tablets at 40°C/75% relative humidity for 6 weeks showed no significant change in physical appearance, Drug content uniformity and In vitro drug release pattern.From the result it can be concluded that Formulation F1 (Chitosan compression coated tablets) and Formulation F4 (Pectin compression coated tablets). Different polymers give different time interval but were suitable for colonic drug delivery as drug release is maximum while compared to other formulations.


Download data is not yet available.


Bhushan Prabhakar Kolte.; Colon Targeted Drug Delivery System – A Novel Perspective. Asian journal of biomedical and pharmaceutical sciences, 2012; 2(14): 1-10.

Nirav Patel, Jayvadan Patel, Tejal Gandhi, Tejal Soni, Shreeraj Shah “Novel Pharmaceutical Ap-proaches for Colon-Specific Drug Delivery: An Overview”Journal of Pharmacy Research Vol.1.Issue 1. July-September 2008, 2-10.

H. RajpurohitP. Sharma, S. Sharma, and A. Bhandari “Polymers for Colon Targeted Drug Delivery Targeting”. Indian J Pharm Sci. 2010 Nov-Dec; 72(6), 689–696.

Anil K. Philip, Betty Philip “Colon Targeted Drug Delivery Systems: A Review on Primary and Novel Approaches” Oman Medical Journal 2010, Volume 25, Issue 2, April 2010, 70-78.

Y.S.R. Krishnaiah, P.R. Bhaskar Reddy, V. Satyanarayana,R.S. Karthikeyan Studies on the development of oral colon targeted drug delivery systems for metronidazole in the treatment ofamoebiasis International Journal of Pharmaceutics 236 (2002) 43–55.

Wolters Kluwer/Lippincott Williams and Wilkins, Illustrated reviews, pharmacology.2009, 4th edition, 417-420.

Kapoor D, Rajora A, Saini V “Formulation Development And Dissolution Enhancement Of Compeba-400 (Metronidazole-400) Tablet Asian Journal Of Biomedical And Pharmaceutical Sciences 1 (2) 2011, 25-31

Lachman L, Liebermann HA, Kiang JL. Theory and practice of industrial pharmacy. 3rd ed. Varghese publishing house; 1991.

M.Praveen Kumar, B. Mohammed Ishaq, J.Ravi Kumar Reddy, R.Pradeep Kumar, A.Badrinath, C. Madhusudhana chetty “Formulation and Evaluation of Colon Specific Matrix and Coated Tablets of Metronidazole” International research journal of pharmacy,2(9),2011,194-199.

Biraju D. Patel, Dhaval V. Patel, Jayant R. Chavda, Mahesh R. Dabhi and Ravi A. Manek “Develop-ment and evaluation of pectin based colon targeted herbal drug delivery system” African Journal of Pharmacy and Pharmacology Vol. 6(25), pp. 1815-1820, 8 July, 2012.

Shaik Shabbeer, I Sudha Madhuri. “Formulation and Development of Mesalamine Sustained Release Guar Gum Matrix for Colon-Specific Drug Delivery” International Journal of Pharmaceutical Research and Development (IJPRD) 2011, Volume 4(02) April 2012, 180-185.

Tarak J. Mehta, Satyanarayan Singh Rajput, Mukesh R. Patel, Kanu R.Patel, Natvarlal M. Patel and Mohan Mothila “Formulation, Development And Optimization Of MetronidazoleCompression Coated Tablets”, Scholars Research Library, Der Pharmacia Lettre, 2011: 3 (5) 94-103.

Patel Jayvadan K., Patel Nirav V. Shah Shreeraj H. “Formulation And In-Vitro Evaluation Of Mesalamine Matrix Tablets Using Chitosan For Colonic Drug Delivery” Journal Of Pharmacy Research 2009, 2(8), 1319-1323.


68 Views | 60 Downloads

How to Cite

Rajkumar, Md. Majid Iqbal, Tukaram Tadmale, and Rohit Saraswat. “Effect Of Polymers On Metronidazole Anti-Amoebic Tablets On Colon Drug Delivery System.”. International Journal of Pharmaceutics and Drug Analysis, vol. 7, no. 3, Mar. 2019, pp. 16-27, https://ijpda.com/index.php/journal/article/view/418.



Research Articles
Share |