SYNTHESIS AND BIOLOGICAL EVALUATION OF ISOINDOLINE-1, 3- DIONE DERIVATIVES
Keywords:
Phthalimide, Analgesic activity, In-vitro anti-inflammatory activity, Protein denaturation techniqueAbstract
A series of phthalimide derivatives were synthesized and evaluated for their analgesic and invitro anti-inflammatory activity. The target compounds were obtained by condensation of N-hydroxymethylphthalimide with the substituted triazole. The structures of the synthesized derivatives were confirmed by means of IR, 1H-NMR spectral data. The analgesic activity was determined by acetic acid induced writhings in mice and Invitro anti-inflammatory activity was evaluated using thermally induced protein denaturation technique. The results revealed the importance of the combination of triazole and phthalimide moieties as a promising analgesic and anti-inflammatory candidate.
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References
S. S. Kadam, K. R. Mahadik, K. G. Bothara, Principles of medicinal chemistry, (2001), vol II, 255- 273
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M.Hamza and R. A. Dionne, Mechanisms of non-opioids analgesics beyond cyclooxygenase enzyme inhibition, Current Molecular Pharmacology, (2009), (2), 1-14,
J. G. Hardman, L. E. Limbird, Goodman and Gilman’s The pharmacological basis of therapeutics, analgesic-antipyretic and anti-inflammatory agents and drugs employed in the treatment of gout, 9th Edn, (1996), 617-657
F. Ahmad, R. A. Khan, S. Rasheed, Study of analgesic and antiinflammatory activity from plant extracts of lactuca scariola and Artemisia absinthium. Journal of Islamic World Academy of Sciences, (1992), 5, 111-114,
H. J. Kim, N. R. Hwang, and K. J. Lee, Heat shock responses for understanding diseases of protein denaturation, Molecular Cells, Vol. 23( 2), 123-131
R. A. Pophale, M. N. Deodhar, Synthesis and evaluation of novel phthalimide derivatives as analgesic and antiinflammatory agents, Der Pharma Chemica, (2010), 2(1), 185-19
M. A. Bhat, M. A. Al-Omar, N. Siddiqui, Synthesis, anticonvulsant and neurotoxicity of some novel 1,3,4-oxadiazole derivatives of phthalimide, Der Pharma Chemica, (2010), 2(2), 1-10
S. P. Mahapatra, P. Ghode, D. K Jain, S. C. Chaturvedi, B. C. Maiti and T. K. Maity, Synthesis and hy-poglycemic activity of some phthalimide derivatives
R. Antunes, H. Batista, R. M. Srivastava, G. Thomas, C. C. Araujo, R. L. Longo, H. Magalhaes, Marcel B. C. Leao, A. C. Pavao, Synthesis, characterization & interaction of new oxadiazolo-phthalimide as peripheral analgesic, Journal of Molecular Structure, (2003), 660, 1–13
J. L. Santos, P. R. Yamasaki, C. M. Chin, C. H. Takashi, F. R. Pavan , C. Q. F. Leite , Synthesis and in vitro anti Mycobacterium tuberculosis activity of a series of phthalimide derivatives, 2009, Bioorganic & Medicinal Chemistry 17 , 3795–3799
C. Kishor Kumar, H. V. Kumar, R. Giriyapura ,V.Kumar, and N.Naika, 3-oxoisoindoline-5-carboxamides Synthesis and their antioxidant activity studies, 2010, Journal of Pharmaceutical Science and Technology ,Vol. 2 (12), 380-390
S. P. Mahapatra, P. Ghode, D. K Jain, S. C. Chaturvedi, B. C. Maiti and T. K. Maity, Synthesis and hypoglycemic activity of some phthalimide derivatives, 2010, J. Pharm.Sci. & Res. Vol.2 (9), 567-578
P. Singh, S. Kaur, V. Kumar, P. M. S. Bedi, M. P. Mahajan , I. Sehar, H. Chandra Pal and A. K. Saxena, Synthesis and in vitro cytotoxic evaluation of N-alkylbromo and N- alkylphthalimido-isatins , 2011
F. Hassanzadeh, M. Rabbani, G. A. Khodarahmi, A. Fasihi, G. H. Hakimelahi, M. Mohajeri, Synthesis of phthalimide derivatives and evaluation of anxiolytic activity, Research in Pharmaceutical Sciences, (2007), 2, 35-41
K. V. Derpoorten, J. Balzarini, E. D. Clercq, J. H. Poupaert, Anti-HIV activity of N-1-adamantyl-4Aminophthalimide, 1997, Biomed & pharmacother,51, 464 – 468
L. M.Sena, R. M. Srivastava, C. A. Simone, S. M. Cruz Goncalves, R. O.Silva & M. A. Pereira, Conventional and microwave assisted reaction of N-hydroxymethylphthalimide with aryl amines: Synthesis of N-(Arylaminomethyl)-phthalimide, 2007, Journal Brazil. Chem.soc., Vol.18, No. 6 , 1224-1234
M. Yadav, S. Kumar, Abu Nasar, Inhibition of corrosion of copper by 4-Amino-3-Phenyl-5-Mercapto-1,2,4-Triazole in 3.5% sodium chloride solution, Asian Journal of Research in Chemistry, 3(4)Oct-Dec.(2010), 932-942.
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