• Y. N. Ingale Department of Pharmaceutical Chemistry, Padmashree Dr.Vithalrao Vikhe Patil Foundation’s College of pharmacy, Vilad Ghat, Ahmednagar, MS, India
  • R. B. Ugale Department of Pharmaceutical Chemistry, Padmashree Dr.Vithalrao Vikhe Patil Foundation’s College of pharmacy, Vilad Ghat, Ahmednagar, MS, India


Phthalimide, Analgesic activity, In-vitro anti-inflammatory activity, Protein denaturation technique


A series of phthalimide derivatives were synthesized and evaluated for their analgesic and invitro anti-inflammatory activity. The target compounds were obtained by condensation of N-hydroxymethylphthalimide with the substituted triazole. The structures of the synthesized derivatives were confirmed by means of IR, 1H-NMR spectral data. The analgesic activity was determined by acetic acid induced writhings in mice and Invitro anti-inflammatory activity was evaluated using thermally induced protein denaturation technique. The results revealed the importance of the combination of triazole and phthalimide moieties as a promising analgesic and anti-inflammatory candidate.


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How to Cite

Y. N. Ingale, and R. B. Ugale. “SYNTHESIS AND BIOLOGICAL EVALUATION OF ISOINDOLINE-1, 3- DIONE DERIVATIVES”. International Journal of Pharmaceutics and Drug Analysis, vol. 6, no. 11, Nov. 2018, pp. 604-9,



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