Fabrication and Characterization of Olopatadine Hydrochloride Loaded Bionanofibers as a Platform for Drug Delivery
Keywords:Moringa oleifera gum, Bionanofibers, Olopatadine hydrochloride, Entrapment efficiency, In-vitro drug release etc
Bionanofibers drug delivery systems are able to improve therapeutic efficacy, reduce toxicity, and increase patient compliance by delivering drugs at controlled rate over a period of time to the site of action. Bionanofibers were individualized from Moringa oleifera gum by a chemical process and then mechanically separated into nanofibers using high- intensity ultrasonication. The obtained bionanofibers were characterized on the basis of fiber length and diameter, morphology, entrapment efficiency and drug release behavior. FE-SEM images showed that the length of obtained bionanofibers is about 10µm with 94nm in diameter. DSC data showed that the endothermic peak at about 253ºC for drug shifted to lower temperature in drug polymer blend. FTIR analysis shows no any significant interaction between drug and polymer. The in-vitro release study demonstrated that there is a controlled release pattern of drug from bionanofibers.
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