Development And Validation Of Liquid Chromatography Method For The Analysis Of Atazanavir In Pharmaceutical Dosage Forms

Authors

  • Sirsat Bhagwat Department Of Quality Assurance, Shri Bhagwan College Of Pharmacy, Aurangabad India.
  • Arsul Vilas A Department Of Quality Assurance, Shri Bhagwan College Of Pharmacy, Aurangabad India.
  • ArsulSupriya V Department Of Quality Assurance, Shri Bhagwan College Of Pharmacy, Aurangabad India.

Keywords:

RP-HPLC Method, Atazanavir, Validation, Recovery

Abstract

Atazanavir is an important antiretroviral drug. The objective of the current study was to develop a simple accurate, precise and rapid RP-HPLC method development and validation for determination of Atazanavir in tablet dosage form. Chromatographic separation was achieved on C18 Column with mobile phase Methanol: (0.1%) OPA (80:20) v/v with flow rate 0.7ml/min and UV detection was carried out on 250nm. Retention time of Atazanavir was found to be 4.302 & Linearity of proposed method was found to be in the range of 10-50 µg/ml (r2=0.999). Method was statistically validated for its linearity, accuracy and precision. Both interday and intraday variation was found to be showing less %RSD (Relative Standard Deviation) value indicating high grade of precision of method.

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References

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Published

2018-07-16
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How to Cite

Sirsat Bhagwat, Arsul Vilas A, and ArsulSupriya V. “Development And Validation Of Liquid Chromatography Method For The Analysis Of Atazanavir In Pharmaceutical Dosage Forms”. International Journal of Pharmaceutics and Drug Analysis, vol. 6, no. 8, July 2018, pp. 563–570, https://ijpda.com/index.php/journal/article/view/407.

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