Cognition improving potentials of aqueous extract of roots of Asparagus adscendens Roxb. in mice


  • Hanumanthachar Joshi Department of Postgraduate studies and Research Division of Pharmacognosy and Photochemistry Sarada Vilas College of Pharmacy, K. M. Puram, Mysore-04, Karnataka, India
  • Majed Abdo Alkanad Department of Postgraduate studies and Research Division of Pharmacognosy and Photochemistry Sarada Vilas College of Pharmacy, K. M. Puram, Mysore-04, Karnataka, India
  • Charan C S Department of Postgraduate studies and Research Division of Pharmacognosy and Photochemistry Sarada Vilas College of Pharmacy, K. M. Puram, Mysore-04, Karnataka, India


Acetyl cholinesterase, Asparagus adscendens, Amnesia, Memory, Scopolamine


The present study involves investigations on the  nootropic activity of aqueous extract of dried roots of Asparagus adscendens Roxb. (AAR) in mice. Elevated plus maze and water maze were the models used for testing learning and memory. Scopolamine (0.4 mg/kg, i.p.) and natural aging induced amnesia  were the interocpetive behavioral models. Piracetam (200 mg/kg, ip) was used as standard drug. AAR (50 and 100 mg/kg, p.o.) significantly attenuated amnesic deficits induced by scopolamine and natural aging. AAR found to increase whole brain acetyl cholinesterase inhibition activity in mice. Aqueous extract of A. adscendens can be useful in treatment of preliminary symptoms of dementia in elderly.


Download data is not yet available.


Prince, M., Bryce, R., Albanese, E., Wimo, A., Ribeiro, W., and Ferri, C. P. The global prevalence of dementia: a systematic review and meta analysis. Alzheimer’s Dement. (2013). 9, 63–75.

Prince, M., Comas-Herrera, A., Knapp, M., Guerchet, M., and Karagiannidou, M. World Alzheimer Report 2016 Improving Healthcare for People Living with Dementia. Coverage, Quality and Costs Now and in the Future. Available online at:

Frozza RL, Lourenco MV, De Felice FG. Challenges for Alzheimer's Disease Therapy: Insights from Novel Mechanisms Beyond Memory Defects. Front Neurosci. 2018 Feb 6;12: 37.

Du X, Wang X, Geng M. Alzheimer's disease hypothesis and related therapies. Transl Neurodegener. 2018, Jan 30;7:2

Rogers EJ, Milhalik S, Ortiz D, Shea TB. Apple juice prevents oxidative stress and impaired cognitive performance caused by genetic and dietary deficiencies in mice. JournalNutr. Health Aging 2003, 7: 1-6.

Sharma PV. Dravyaguna vijnan, 1982; .2nd ed., Chaukambha Bharati Academy, Varanasi, 562.

Goyal R, Singh J and Lal H. Asparagus racemosus--an update. Indian journal of medical sciences. 2003, 57: 408-410.

Hayes PY, Jahidin AH, Lehmann R, Penman K, Kitching W and De Voss JJ. Steroidal saponins from the roots of Asparagus racemosus. Phytochemistry 2008, 69, 796-804.

Chauhan N.S. Medicinal and aromatic plants of Himachal Pradesh. Indus Publishing., 1999, 22-24.

Bansode FW, Arya KR, Singh RK, Narender T. Dose-dependent effects of Asparagus extract on the anabolic, reproductive, and sexual behavioral activity in rats. Pharmaceutical biology 2014, 6, 1-9.

Parle M, Dhingra D, Kulkarni SK. Memory-strengthening activity of Glycyrrhiza glabra in exteroceptive and interoceptive behavioral models. Journal of Medicinal Food . 2004, 7(4), 462.

Organization for Economic Co-operation and Development 2001. Guideline 423.Acute oraltoxicity.[]orDiener, W; U Mischke, E Schlede and D Kayser (1995). The biometric evaluation of the OECD modified version of the acute toxic category method (oral). Arch.Toxicol. 2001, 69, 729-734.

Itoh J, Nabeshima T, Kameyama T. Utility of an elevated plus maze for the evaluation of nootropics, scopolamine and electro convulsive shock. Psychopharmacology 1990, 101, 27-33.

Parle M, Dhingra D. Ascorbic acid: a promising memory enhancer in mice. Journal of Pharmaceutical Sciences.2003, 93, 129-135.

Biradar SM, Joshi H, Chheda TK. Neuro pharmacological effect of Mangiferin on brain cholinesterase and brain biogenic amines in the management of Alzheimer's disease. European Journal of Pharmacology. 2012, 683,140-147.

Joshi H, Parle M. Nardostachys jatamansi improves learning and memory in mice. Journal of Medicinal Food . 2006, 9, 113-118.

Joshi H, Parle M. Effects of piperine on memory and behavior mediated via monoamine neurotransmitters. J Trad Med. 2005, 2, 39-43.

Ellman GL, Courtney KD, Valentino A, Featherstone RM. A new and rapid colourimetric determination of acetylcholinestrase activity. Biochem Pharmacol. 1961, 7, 88-95.

Morris R. Developments of a water-maze procedure for studying spatial learning in the rat. J Neurosci Methods, 1984, 11(1), 47-60.

Hooge D R, Deyn P. Application of the Morris water maze in the study of learning and memory. Brain Research Reviews, 2001, 36(01), 60-90.

Joshi H, Parle M. Antiamnesic Effects of Desmodium gangeticumin Mice. Yakuga kuzasshi 2006, 126, 795-804.

Joshi H, Parle M. Antiamnesic potentials of Foeniculum vulgare Linn. in mice. Oriental Pharmacy and Experimental Medicine. 2007, 7 (2), 121-129.

Agnolli A, Martucci N, Manna V, Conti L. Effect of cholinergic and anticholinergic drugs on short term memory in electroencephalographic study Clinical Neuropharmacology. 1983, 6, 311.

White house PJ, Price DL, Struble RG, Clark AW, Coyle JT, Delon MR. Alzheimer’s disease and senile dementia; loss of neurons in the basal forebrain. Science 1982, 215, 1237.

Collinge J. Mammalian prions and their wider relevance in neurodegenerative diseases.Nature. 2016, 539(7628), 217-226.

Hanumanthachar Joshi, Milind Parle, Nardostachys jatamansi improves learning and memory in mice. J Med Food. 2006, 9, 113-118.

Hanumanthachar Joshi, Milind Parle. Antiamnesic potentials of Foeniculum vulgare Linn. in mice. OPEM 2007, 7,121-129.

Hanumanthachar Joshi, Majed Abdo Alkanad, Charan C S. Ameliorative Effects of Roots of Asparagus adscendens Roxb. on Cognitive Impairments and Brain Aging Induced By Scopolamine and Diazepam in Animal Models Relevant to Alzheimer's Disease. Journal of Pharmaceutical Research, 2017, 16( 3), 199-207.

Joshi H, Parle M. Zingiber officinale: Evaluation of its nootropic effect in mice. African Journal of Traditional, Complementary and Alternative medicines. 2006, 3, 64-74.

Lu, T. & Liviu Aron, Joseph Zullo, Ying Pan, Haeyoung Kim, Yiwen Chen, Tun-Hsiang Yang, Hyun-Min Kim, Derek Drake, X. Shirley Liu, David A. Bennett, Monica P. Colaiácovo, Bruce A Yankner. Addendum: REST and stress resistance in ageing and Alzheimer’s disease. Nature 2016, 507, 448–454.


31 Views | 18 Downloads

How to Cite

Hanumanthachar Joshi, Majed Abdo Alkanad, and Charan C S. “Cognition Improving Potentials of Aqueous Extract of Roots of Asparagus Adscendens Roxb. In Mice”. International Journal of Pharmaceutics and Drug Analysis, vol. 6, no. 3, Mar. 2018, pp. 384-90,



Research Articles
Share |