Cognition improving potentials of aqueous extract of roots of Asparagus adscendens Roxb. in mice
Keywords:Acetyl cholinesterase, Asparagus adscendens, Amnesia, Memory, Scopolamine
The present study involves investigations on the nootropic activity of aqueous extract of dried roots of Asparagus adscendens Roxb. (AAR) in mice. Elevated plus maze and water maze were the models used for testing learning and memory. Scopolamine (0.4 mg/kg, i.p.) and natural aging induced amnesia were the interocpetive behavioral models. Piracetam (200 mg/kg, ip) was used as standard drug. AAR (50 and 100 mg/kg, p.o.) significantly attenuated amnesic deficits induced by scopolamine and natural aging. AAR found to increase whole brain acetyl cholinesterase inhibition activity in mice. Aqueous extract of A. adscendens can be useful in treatment of preliminary symptoms of dementia in elderly.
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