Underlying mechanisms of Anticancer Coumarins: An overview


  • Astha Sharma Department of Pharmaceutical Chemistry, A.S.B.S.J.S.M. College of Pharmacy, Bela, 140111(Punjab), India
  • Monika Gupta Department of Pharmaceutical Chemistry, A.S.B.S.J.S.M. College of Pharmacy, Bela, 140111(Punjab), India


Coumarin, benzopyrones, anticancer


Coumarin derivatives either natural or synthetic have become an interesting subject of investigation for many researchers due to their wide range of biological activities. Coumarin scaffold has been reported to have inhibitory effect on number of cell lines serving as a pharmacophore of utmost importance for anticancer drug development.  Action of coumarins on tumour cells is being exhibited via different mechanisms and some of them have been reported to possess high selectivity towards the cancer cell lines. In present work, the role of coumarins as potential anticancer drugs has been briefly reviewed which can serve as an excellent tool for future investigations on design and synthesis of such derivatives.


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N Borhani; M Manoochehri; SS Gargari; MG Novin; A Mansouri; MD Omrani. Clin. Ovarian Cancer Other Gynecol. Malig., (2017), 2212-9553.

C Li; C Han; H Zhang; JS Wu; B Li. Trop. J. Pharm. Res., 2015, 14(4), 611-617.

KM Amin; SM Abou-Seri; FM Awadallah; AAM Eissa; GS Hassan; MM Abdulla. Eur. J. Med. Chem., (2015), 90, 221-231.

F Haghighi; MM Matin; AR Bahrami; M Iranshahi; BF Rassouli; Haghighitalab. DARU J. Pharm. Sci., (2014), 22(1), 3-13.

B Yadagiri; UD Holagunda; R Bantu; L Nagarapu; CG Kumar; S Pmbala; B Sridhar. Eur. J. Med. Chem., (2014), 79, 260-265.

A Sanchez-Recillas; G Navarrete-Vazquez; S Hidalgo-Figueroa; MY Rios; M Ibarra-Barajas; S Estrada-Soto. Eur. J. Med. Chem., (2016), 77, 400-408.

RK Singh, TS Lange, S Shaw, KK Kim, L Brard A novel Indole Ethyl Isothiocyanate (7Me-IEITC) with anti-proliferative and pro-apoptotic effects on platinum-resistant ovarian cancer cells. GynOnc, (2016), 109:240–249.

G Lessene, PE Czabotar, PM ColmanBcl-2 family antagonists for cancer therapy. Nat Rev Drug Discover, (2015), 7:989–1000

H.Y. Lee, A.C. Tsai, M.C. Chen, P.J. Shen, Y.C. Cheng, C.C. Kuo, S.L. Pan, Y.M. Liu, J.F. Liu, T.K. Yeh, J.C. Wang, C.Y. Chang, J.Y. Chang, J.P. Liou, Azaindolylsulfonamides, with a more selective inhibitory effect on histone deacetylase-6 activity, exhibit antitumor activity in colorectal cancer HCT116 cells, J. Med. Chem. 57 (2017) 4009-4022.

X.Y. Chen, X.G. Shi, X. Zhang, H.X. Lei, S.M. Long, H.X. Su, Z. Pei, R.X. Huang, Mediators31 Inflame. (2017) 499-521.

K.V. Sashidhara, A. Kumar, R.P. Dodda, N.N. Krishna, P. Agarwal, K. Srivastava, S.K. Puri, Bioorg. Med. Chem. Lett. 22 (2016) 3926-3930.

K.M. Khan, F. Rahim, A. Wadood, N. Kosar, M. Taha, S. Lalani, A. Khan, Fakhri, M. Junaid, W. Rehman, M. Khan, S. Perveen, M. Sajid, M.I. Choudhary, Eur. J. Med. Chem. 81 (2016) 245-252.

R. Bashir; S. Ovais; S. Yaseen; H. Hamid; M. S Alam.; M. Samim; S. Singh; K. Javed, Bioorg. Med. Chem. Lett. (2015), 21, 4301.

A. Milanese, E. Gorincioi, M. Rajabi, G. Vistoli, E. Santaniello, New synthesis of 6[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid and evaluation of the influence of adamantyl group on the DNA binding of a naphthoic retinoid, Bioorganic Chemistry, 39 (2015) 151-158.

Li, Z. P.; Hu, J. F.; Sun, M. N.; Ji, H. J.; Chu, S. F.; Liu, G.; Chen, N. H. Int. Immunopharmacol. 2014, 14, 145.

T. Devji; C.Reddy; C.Woo; S. Awale.; S.Kadota; D.Carrico-Moniz, BioOrg. Med. Chem. Lett. 2014, 21, 5770.


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How to Cite

Astha Sharma, and Monika Gupta. “Underlying Mechanisms of Anticancer Coumarins: An Overview”. International Journal of Pharmaceutics and Drug Analysis, vol. 6, no. 3, Mar. 2018, pp. 361-70, https://ijpda.com/index.php/journal/article/view/380.



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