Formulation And Evaluation Of Mouth Dissolving Tablet Of Prochlor-perzine Maleate
Keywords:
Prochlorperzine maleate, Croscarmellose Sodium, Crospovidone, Sodium starch glycolateAbstract
Rapidly disintegrating oral tablet are gaining popularity over conventional tablets due to their convenience in administration and suitability for patients having dysphagia. Moreoverno water is required for swallowing the tablets and hence suitable for geriatric, pediatric and traveling patients. Superdisintegrants like 4 % & 8 % (Croscarmellose Sodium, Crospovidone and sodium starch glycolate), Binder (Povidone K-30), Diluent (Starlac) along with sweetening agent (aspartame) were used in the formulation of tablets by direct compression technique. The granules were evaluated for angle of repose, bulk density, tapped density, carr’s index and hausner’s ratio. The tablets were evaluated for hardness, friability, water absorption ratio, in-vitro disintegration time (DT) and in vitro drug release. In-vitro release studies were performed using USP XXIII apparatus-2 (paddle method) in 900ml of pH 1.2 at 50rpm. Maximum % drug release (97.82 %) and minimum disintegration time (23.67 second) were observed with formulation F3 comprising of crospovidone prepared by direct compression technique.
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