Formulation And Evaluation Of Mouth Dissolving Tablet Of Prochlor-perzine Maleate

Authors

  • Arun Kumar Pandey Department of Pharmaceutics Sri SatyaSai University of Technology and Medical Sciences, Sehore, Madhya pradesh.
  • Pavan Kumar Rawat Department of Pharmaceutics Sri SatyaSai University of Technology and Medical Sciences, Sehore, Madhya pradesh.
  • C.K.Tyagi Department of Pharmaceutics Sri SatyaSai University of Technology and Medical Sciences, Sehore, Madhya pradesh.
  • Sunil Shah Department of Pharmaceutics Sri SatyaSai University of Technology and Medical Sciences, Sehore, Madhya pradesh.

Keywords:

Prochlorperzine maleate, Croscarmellose Sodium, Crospovidone, Sodium starch glycolate

Abstract

Rapidly disintegrating oral tablet are gaining popularity over conventional tablets due to their convenience in administration and suitability for patients having dysphagia. Moreoverno water is required for swallowing the tablets and hence suitable for geriatric, pediatric and traveling patients. Superdisintegrants like 4 % & 8 % (Croscarmellose Sodium, Crospovidone and sodium starch glycolate), Binder (Povidone K-30), Diluent (Starlac) along with sweetening agent (aspartame) were used in the formulation of tablets by direct compression technique. The granules were evaluated for angle of repose, bulk density, tapped density, carr’s index and hausner’s ratio. The tablets were evaluated for hardness, friability, water absorption ratio, in-vitro disintegration time (DT) and in vitro drug release. In-vitro release studies were performed using USP XXIII apparatus-2 (paddle method) in 900ml of pH 1.2 at 50rpm. Maximum % drug release (97.82 %) and minimum disintegration time (23.67 second) were observed with formulation F3 comprising of crospovidone prepared by direct compression technique.

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References

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Published

2018-01-02
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How to Cite

Arun Kumar Pandey, Pavan Kumar Rawat, C.K.Tyagi, and Sunil Shah. “Formulation And Evaluation Of Mouth Dissolving Tablet Of Prochlor-Perzine Maleate”. International Journal of Pharmaceutics and Drug Analysis, vol. 6, no. 1, Jan. 2018, pp. 13-21, https://ijpda.com/index.php/journal/article/view/326.

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