PHYTOSOME: A NOVEL DRUG DELIVERY SYSTEM IN THE MIDDLE OF IMPROVED BIOAVAILABILITY
Keywords:Phytosome, Phospholipids, Bioavaibility, flavonoids, herbosomes
Novel Drug Delivery System in the field of medicine had taken a popular attention now a day as it makes the intake, bioavaibility and overall therapeutics of a drug easier and in short period of time. In recent times the emerging technology of drug delivery and drug targeting is also being applied to Phytopharmaceuticals. In current herbal drugs have been widely used because of their less side effects, cost effectiveness and easy availability. Current review deals one of the herbal Novel Drug Delivery System i.e. Phytolipid Delivery System Phytosomes are recently introduced herbal formulations that are better absorbed, and as a result produce better bioavailability and actions than the conventional phytomolecules or botanical extracts. The term “Phyto” means plant while “some” means cell-like. It is also often known as herbosomes. Phytosome technology has been effectively used to enhance the bioavailability of many popular herbal extracts and can be developed for various therapeutic uses or dietary supplements.
Cott J.; Natural Product Formulations Available in Europe for Psychotropic Indications, Psychopharmacol Bull, 1995, 31(4), 745.
Bombardelli E, Curri SB, Della RL, Del NP, Tubaro A, Gariboldi P, Complexes Between Phospholipids and Vegetal Derivatives of Biological Interest.,Fitoterapia. 1989, 60(1),1-9.
Dang Yi. New product concept. UPC code 0300540111783. 2000.
Manach C, Scalbert A, Morand C. Polyphenols; Food Sources and Bioavailabilit, Am J Clin Nutr. 2004, 79, 727-47.
Mascarella S; Therapeutic and Antilipoperoxidant Effects of Silybin-Phosphatidylcholine Complex in Chronic Liver Disease, Preliminary Results, Curr Ther Res. 1993, 53(1),98-102.
Bombardelli E, Cristoni A, Morazzoni P. Phytosomes in Functional Cosmetics. Fitoterapia. 1994; 95:387-401.
Bombardelli E. Phytosome: New Cosmetic Delivery System, Boll Chim Farm. 1991, 130,431-38.
Bombardelli E, Spelta M. Phospholipid-Polyphenol Complexes: A New Concept in Skin Care Ingredients. Cosm & Toil, 1991, 106, 69-76.
Murray D. Phytosomes- Increase the Absorption of Herbal Extract [online]. 2008 [cited 2008 Sep 28]. Available from: URL: www.doctormurray.com/articles/silybin.htm
Phytosomes: A Technical Revolution in Phytomedicine [online]. 2010 [cited 2010 Mar 22]. Available from: URL: http://www.indena.com
Jose MM, Bombardelli E. Pharmaceutical Compositions ContainingFlavanolignans and Phospholipida Active Principles. U.S. PatentEPO209037. 1987.
Sharma S, Sikarwar M. Phytosome: A Review. Planta Indica .2005, 1:1-3.
Kidd P, Head K.; A Review of the Bioavailability and ClinicalEfficacy of Milk Thistle Phytosome: A Sily-binphosphatidylcholineComplex, Altern Med Rev. 2005, 10,193-203.
Bombardelli E, Spelta M, Loggia Della R, Sosa S, Tubaro A.; Aging Skin: Protective Effect of Silymarin- Phytosome. Fitoterapia, 1991, 62(2), 115-22.
Bombardelli E, Mustich G. Bilobalide Phospholipid Complex, Their Uses and Formulation Containing Them. U.S. Patent EPO-275005. 1991.
Franco PG, Bombardelli, E. Complex Coppouns of BioflavonoidsWith Phospholipids, Their Preparation, Uses and Pharmaceuticaland Cosmetic Compositions Containing Them. U.S. Patent No-EPO275005. 1998.
Jain NK, Controlled and Novel Drug Delivery. CBS publisher NewDelhi, 2001.
Valenzuela A, Aspillaga M, Vial S, Guerra R.; Selectivity of Silymarin on the Increase of the Glutathione Content in Different Tissues of the Rat, Planta Med, 1989, 55(5),420-22.
Hikino H, Kiso Y, Wagner H, Fiebig M. ;Antihepatotoxic Actions of Flavonolignans from Silybum Mari-anum Fruits.,Planta Med, 1984, 50(3), 248-250.
Kidd PM. ;Phosphatidylcholine: A Superior Protectant against Liver Disease, Altern Med Rev, 1996, 1,258-74.
Francesco D P, Anna B M, Angela B, Maurizio L, Andrea C; Green Select Phytosome as an Adjunct to a Low-Calorie Diet for Treatment of Obesity: A Clinical Trial, Altern Med Rev 2009, 14, 154-160
Mukherjee K, Maiti K, Venkatesh M, Mukherjee PK. Phytosome of Hesperetin, A Value Added Formula-tion with Phytomolecules. 60th Indian Pharmaceutical Congress; New Delhi, 2008, p. 287.
Yanyu X, Yunmei S, Zhipeng C, Quineng P; The Preparation of Silybin-Phospholipid Complex and the Study on Its Pharmacokinetics in Rats. Int J Pharm, 2006, 307, 77-82.
Ravarotto L; Eficacy of Silymarin-Phospholipid Complex in Reducing the Toxicity of Aflatoxin B1in Broiler Chick’. Poult Sci, 2004, 83, 1839-43.
Busby A, LaGrange L, Edwards J, King J; The use of A Silymarin/ Phospholipid Compound As A Fetoprotectant From Ethanol-Induced Behavioral Deficit, J Herb Pharmacother, 2002, 2(1),39-47.
Maiti K, Mukherjee K, Gantait A, Ahamed HN, Saha BP, Mukherjee PK; Enhanced Therapeutic Benefit of Quercetin– Phospholipid Complex In Carbon Tetrachloride Induced Acute Liver Injury In Rats: A Comparative Study, Iran J Pharmacol Ther.2005, 4,84–90.
Barzaghi N, Crema F, Gatti G, Pifferi G, Perucca E; Pharmacokinetic Studies on Idb 1016, A Silybin Phosphatidylcholine Complex In Healthy Human Subjects. Eur J Drug Metab Pharmacokinet, 1990, 15,333-38.
Moscarella S, Giusti A, Marra F, Marena C, Lampertico M, Relli P, Gentilini P, Buzzelli G; Therapeutic And Antilipoperoxidant Effects of Silybin Phosphatidylcholine Complex In Chronic Liver Disease: Preliminary Results, Curr Ther Res. 1993, 5, 98-102.
La Grange L, Wang M, Watkins R, Ortiz D, Sanchez ME, Konst J, Lee C, Reyes E; Protective Effects of The Flavonoids Mixture, Silymarin, On Fetal Rat Brain and Liver, J Ethnopharmacol. 1999, 65,53-61.
Schwitters B, Masquelier J. OPC in Practice: Biflavanals and Their Application. Alfa Omega Rome. Italy 1993.
Phospholipids: The Vital Lipids [online]. 2010 [cited 2010 Mar 26].mAvailable from: URL: www.phospholipidsonline.com
Vitamedics, Phytosome Products [online]. 2008 [cited 2008 Sep 19]. Available from: URL: http://www.vitamedics.com
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