Differential spectrophotometric method for estimation and validation of Verapamil in Tablet dosage form


  • Leena Trivedi Kamla Nehru College of Pharmacy, Butibori, Nagpur 441108, Maharashtra, India
  • Roshan Telrandhe Kamla Nehru College of Pharmacy, Butibori, Nagpur 441108, Maharashtra, India
  • Disha Dhabarde Kamla Nehru College of Pharmacy, Butibori, Nagpur 441108, Maharashtra, India


Difference spectrophotometry, Verapamil, Calibration, Tablet, Validation


The aimed of current research to development of the simple, rapid and sensitive Differential spectrophotometric method for the estimation of Verapamil in tablet dosage form. In this method two medium was use acid and alkaline and the difference spectrum was calculated. 0.1N HCL and 0.1N NaOH was used in this differential method. The ?max 278, Beers law limits 5-25µg/ml, regression equation Y= 0.024x-0.009, slope 0.024, intercept 0.09, correlation coefficient (r2) 0.998, %RSD <1.5, % Recovery (Tablet) 100.46% was shows the good efficacy and results. This method future scope in quality control of the verapamil in simple, precise and economically and it recommended for the routine drug quality analysis investigation.


Download data is not yet available.


Sayanna K, Venkateshwarlu G. Spectrophotometric Determination of Cardiovascular Drugs. Int J Mod Engi Res. 2013;3(5): 3079-3085.

Telarandhe R. Nanotechnology for cancer therapy: Recent developments. Eur J Pharm Med Res. 2016;3(11): 284-294.

Bhaskar R, Bhaskar R, Sagar M A, Saini V, Bhat K. Simultaneous Determination of Verapamil Hydrochloride and Gliclazide in Synthetic Binary Mixture and Combined Tablet Preparation by Chemometric-Assisted Spectroscopy. J Ana Sci Metho Instru. 2012;2: 161-166.

Telrandhe R, Mahapatra D K, Kamble M A. Bombax ceiba thorn extract mediated synthesis of silver nanoparticles: Evaluation of anti-Staphylococcus aures activity. Int J Pharm Drug Analysis. 2017;5(9): 376-379.

Salh D M. Spectrophotometric Determination of Isoptin (Verapamil Hydrochloride) in Pharmaceutical Preparations. IBN AL-HAITHAM J FOR PURE & APPL SCI. 2010;23(3): 1-10.

Shende V, Telrandhe R. Formulation and evaluation of Tooth Gel from Aloe vera leaves extract. Int J Pharm Drug Analysis. 2017;5(10): 394-398.

Elimam M M, Shantier S W, Gadkariem E A. Differential Spectrophotometric Method for Determination of Florfenicol. Chem Sci Trans. 2016;5(4): 1063-1067.

Deshmukh P, Telrandhe R, Gunde M. Formulation and Evalua-tion of Herbal Toothpaste: Compared With Marketed Preparation. Int J Pharm Drug Analysis. 2017;5(10): 406-410.

Shantier S, Gadkariem. Differential Spectrophotometric Method for Determination of Cefquinome Sul-phate. Bri J Pharm Res. 2014;4(5): 617-625.

Kumar G M, samy C K, Kumar P D, Nagaraju C, Ahamadi S S, Yunus S B. Development and validation of differential spectrophotometric method for determination of nelfinavir mesylate in tablet dosage form. Int J Res Pharm Nano Sci. 2013;2(3): 358-364.

Hapse S A, Kadaskar P T, Shirsath A S. Difference spectrophotometric estimation and validation of ibuprofen from bulk and tablet dosage form. Scholars Res Lib. 2011;3(6): 18-23.

Nnadi C O, Agbo M O, Uzor P F, Ugwu L O. Development of Differential Spectrophotometric Method for Assay of Paracetamol in Pure and Tablet Dosage Forms. Indian J Pharm Res. 2013;1(1): 15-21.


23 Views | 18 Downloads

How to Cite

Leena Trivedi, Roshan Telrandhe, and Disha Dhabarde. “Differential Spectrophotometric Method for Estimation and Validation of Verapamil in Tablet Dosage Form”. International Journal of Pharmaceutics and Drug Analysis, Nov. 2017, pp. 419-22, https://ijpda.com/index.php/journal/article/view/311.



Research Articles
Share |