Minoxidil Emulgel for Androgenic Alopecia: A Literature Review Including Patents
Keywords:Minoxidil, Androgenic alopecia, Emulgel, Patents, Polymers
Minoxidil is a powerful vasodialator (antihypertensive drug), i.e. direct relaxation of arteriolar smooth muscle with little effect on venous capacitance. Minoxidil is the only FDA approved topical medication with proven efficacy for the treatment of androgenic alopecia. Alopecia is characterized by round or oval patches of non-scarring hair loss. It is believed that it only causes scalp hair loss that may be partial (transient or persistent) or complete (alopecia totalis), but sometimes it may progress to cause total body hair loss (alopecia universalis). Eumlgels are emulsion gels which contains randomly distributed oil microdroplets. They are emulsions either of oil-in- water or water-in-oil type, which are gelled by mixing with gelling agent. Emulgels have been found to be novel approach for the treatment of various topical disorders. According to the various literature collected emulgels were found to be optimum over other topical preparations i.e. gel, cream, etc.
Anthony C Maffot, M.David Osselton. Brian Widdop. Clarkes Analysis of drug and Poison in Pharmaceutical Body Fluid and Postmortem Material. London Pharmaceutical Press. Electric Version. 3rd edition Volume I.
Bhowmik Debjit, Chiranjib, Chandira Maergret, Jayakar. B, Sampath K.P. Recent advances in Transdermal Drug Delivery System. A Research Article. International Journal of PharmTech Research. 2010. 2 (1). 68-77.
Bois F.C, Rault I, Steiger M. Topical Compositions. EP2214642 A1
Cavallari Cristiana, Luppi Barbara, Maria Di P.A, Rodriguez Lorenzo; Pharmaceutical Preparations for Transdermal Use. EP 2019666 A2.
Cavallari Cristiana, Luppi Barbara, Maria Di P.A, Rodriguez Lorenzo; Pharmaceutical Preparations for Transdermal Use. WO2007129162 A2.
Date Namrata B, Purohit G. Angira, S.Smita, chaudhari D. Pravin. Formulation and Evaluation of Coated Microneedles for the treatment of Hair loss. A Research Article. Intenational Journal of Research and Reviews in Pharmacy and Applied Sciences. 2014. 4 (2). 1083-1101
Falk, Edgar R, Asculai, Simon S. Topical composition containing hyaluronic acid and NSAIDS. 5639738.
Florey Klaus. Analytical Profiles of Drug Substances. Volume 17. 185-220.
FM Sakr, et al. Preparation and evaluation of a multimodal minoxidil microemulsion versus minoxidil alone in the treatment of androgenic alopecia of minoxidil etiology: a pilot study. A research article. NCBI. 2013. (7). 413-423.
Friedman D, Schwartz J, Aviv H. Topical and Transdermal Delivery System utilizing submicron oil spheres. US 6004566 A.
Friedman D, Schwartz J, Aviv H. Topical and Transdermal Delivery System utilizing submicron oil spheres. US 6113921 A.
George Eby and Mathews Manju Maria. Formulation and Evaluation of Topical Gel containing Hair Growth Promoters for the Treatment of Androgenic Alopecia. A Research Article. 2014. 4(1). 1-8.
Hardenia Anu, Jayronia Sonali and Jain Sanjay. Emulgel: An emergent tool in topical drug delivery. A review International Journal of Pharmaceutical Science and Research, 2014; 5(5): 1653-1660
Helal Doaa, Rhman Dalia Abdel, Halim Abdel, Nabarawi Mohamed A. El. Formulation and Evaluation of Fluconazole Topical Gel. A research article. Intrnational Journal of Pharmacy and Pharmaceutical Sciences. 2012. 4(5). 175-183.
Hosny M. Khaled, Shatha M. Rambo, Zaahara Charaterization, and Pharmacodynamic Evaluation. International Journal of Sciences. 2013. 20(2). 306-310.
http://www.drugs.com/minoxidil.html. Minoxidil-FDA prescribing information, side effects and uses.pdf.
Jain Ankur, Gautam P Surya, Gupta Yashwant, Khambete Hemant, Jain Sanjay. Development and Charaterization of Ketoconazole Emulgel for Topical Drug Delivery. A Research article. Pelagia Research Library. 2010.1(3). 221-231.
Joshi Baibhav, Singh Gurpreet, Rana AC, Saini Seema. Development and Characterization of Clarithromycin Emulgel for Topical Delivery. A Research article. International Journa of Drug Development and Research. 2012. 4(3). 310-323.
K.D Triphati. Essentials of Medical Pharmacology. Jaypee Brothers. 5th ed. 2003. 512.
Kute S.B and Saudagar R.B. Emulsified Gel a Novel approach for delivery of hydrophobic drugs: An overview. A review; Journal of Advanced Pharmacy Education and Research, 2013; 3(4): 368-376
Mohamed I Magdy. Optimisation of Chlorphenesin Emulgel Formulation. A research article. The AAPs Journal. 2004. 6(3). 1-7
Patil Suchita, Dr. Sarode Suraj, Prof. Sathe B.S., Dr. Jain P.V., Jain B.V., Dr. Vadnere G.P. Formulation and Evaluation of Etodolac Trans-Emulgel. A Research article. World Journal of Pharmacy and Pharmaceutical Sciences. 2014. 3(7). 1731-1749.
Purushottam Sonaje Sumeet, Bhaskarrao Gondkar Sheetal, Bhandudas Saudagar Ravindra. Gellified Emulsion: A New Born Formulations For Topical Delivery of Hydrophobic Drugs. A Review, World Journal of Pharmacy and Pharmaceutical Sciences, 2013; 3(1): 233-251.
Rabinarayan Parhi, Bhaskara Rao Terapalli, Teja B.B. Formulation and In Vitro Evaluation of Minoxidil Topical Gel. A Research Article. Turk J Pharm Sci. 2014. 11 (2). 153-162.
Ranga Priya. M, Sellakumar V, Nataranjan R, K Mohan. Formulation and In-Vitro Evaluation of Ciprofloxacin Loaded Topical Emulgel. A research article. International Journal of Pharmaceutical and chemical sciences. 2012. 1(1). 237-242.
S. Sunitha. Formulation and Evaluation of Minoxidil Gels for Topical Application. A Research Article. Journal of Parma Research. 2014. 3 (1). 7-10.
Shatalebi M.A, Rafiei.Y. Preparation and evaluation of Minoxidil Foamable Emu Oil Emulsion. A Research Article. Research in Pharmaceutical Sciences. 2014. 9 (2). 123-133.
Singla Vikas, Saini Seema, Baibhav Joshi and Rana AC. Emulgel: A New Platform for Topical Drug Delivery. A Review Article. International Journal of Pharma and Biosciences. 2012. 3(1). 485-498.
United State of Pharmacopeia, The official Compendia of Standards. Asian Edition. 2005. 1300
Verma Swati, Singh Kumar Anil and Mukherjee Alok. Formulation and Evaluation of Ketoconazole Nanoemulgel. A research article. World Journal of Pharmacy and Pharmaceutical Sciences. 2015. 5(2). 899-911.
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