FORMULATION AND EVALUATION OF FAST DIS-INTEGRATING TABLETS OF SERTRALINE HCL BY USING NATURAL SUPER DISINTEGRANTS

Authors

  • Mahesh Gaikwad Department of Quality Assurance Techniques, MES’s college of Pharmacy, Sonai, Maharashtra, India.
  • Vinayak Deshmukh Department of Quality Assurance Techniques, MES’s college of Pharmacy, Sonai, Maharashtra, India.
  • Anil Pawar Department of Quality Assurance Techniques, MES’s college of Pharmacy, Sonai, Maharashtra, India.
  • Prashant Ghule Mula Rural institute of pharmacy, Sonai, Maharashtra, India.
  • Sooraj Bendre Mula Rural institute of pharmacy, Sonai, Maharashtra, India.
  • Sanket Jangale Mula Rural institute of pharmacy, Sonai, Maharashtra, India.

Keywords:

Sertraline Hcl, FDT, Direct compression techniques, Superdisintegrants, FTIR

Abstract

The speed of onset of action of antidepressant is clinically important for several reasons. Objective of this research was to formulate fast disintegrating tablets of sertraline hydrochloride by using natural superdisintegrants so that it will minimize time of onset of action and also become economic. Direct compression method is use to prepare fast disintegrating tablets. Paper describes impact of different concentration of natural superdisintegrants like gelatinized starch, treated agar on various parameters of fast disintegrating tablets of sertraline Hcl. All formulation were evaluated for various parameters such as hardness, friability, drug content, wetting time, dissolution study, disintegration test. An optimized formulation (GS-6) was found to have good hardness of 3.10 kg/cm2, disintegration time of 22.37 second and dissolution of 95 % in 12 min.The conclusion is results obtained clearly indicate that optimized batch GS-6 having remarkable increase in disintegrating and dissolution time for the treatment of depression.

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References

Ved P, Mann S, Yadav S. Fast disintegrating tablets: opportunity in drug delivery system. Journal of advanced pharmaceutical technology & research 2011; 223-235.

Tomar N, Tomar M. Formulation & evaluation of fast disintegrating tablets of caffeine by using effervescent formulation approach. Scholars research library der pharmacia letter 2012; 1490-1494.

Yourong FU, Shicheng Y. Orally fast disintegrating tablets. Critical reviews in therapeutic drug carrier systems 2004; 433-475.

Jain C, Naruka P. Formulation & evaluation of fast dissolving tablets of valsartan. International journal of pharmacy and pharmaceutical sciences 2009; 219-226.

Rao N, Kota R. Formulation & evaluation of fast dissolvingchlorthalidone tablets. International journal of pharmacy and pharmaceutical sciences 2009; 79-87.

Patel B, Patel D. Development and invitro evaluation of fast dissolvingtablets of glipizide. International journal of pharmacy and pharmaceutical sciences 2009; 145-150.

Jonwal N, Mane P. Preparation and invitro evaluation of mouth dissolvingtablets of Domperidone. International journal of pharmacy and pharmaceutical sciences 2010; 170-172.

Wagh M, Yewale C. Formulation & evaluation of fast dispersibletablets of aceclofenac using different superdisintegrants. International journal of pharmacy and pharmaceutical sciences 2010; 154-157.

Behin R, Punitha I. Formulation & characterization of fast disintegrating tablets of amlopidine using disintegrants. Journal of Applied pharmaceutical sciences 2012; 218-223.

Mohsin A, Nimbalkar N. Formulation & evaluation of mouth dissolvingtablets of amitriptyline Hcl by direct compression technique. International journal of pharmacy and pharmaceutical sciences 2010; 204-210.

Published

2016-12-22
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How to Cite

Mahesh Gaikwad, Vinayak Deshmukh, Anil Pawar, Prashant Ghule, Sooraj Bendre, and Sanket Jangale. “FORMULATION AND EVALUATION OF FAST DIS-INTEGRATING TABLETS OF SERTRALINE HCL BY USING NATURAL SUPER DISINTEGRANTS”. International Journal of Pharmaceutics and Drug Analysis, vol. 4, no. 12, Dec. 2016, pp. 533-41, https://ijpda.com/index.php/journal/article/view/261.

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Research Articles
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