• Md Salahuddin Ansari College of Pharmacy Aldawadmi. Shaqra University, KSA
  • Abdulmohsen H. AlRohaimi College of Pharmacy Aldawadmi. Shaqra University, KSA
  • Khalid U Khayyam Department of Public Health and Respiratory Disease, LRS Institute of Tuberculosis and Respiratory Disease, Sri Aurbindo Marg, New Delhi (India)
  • Manju Sharma Department of Pharmacology, Jamia Hamdard, New Delhi (India)
  • Md Sarfaraz Alam Department of Pharmaceutics, College of Pharmacy, Jizan University, KSA


Tuberculosis, Non-Compliance, Psychological Factors, Personal Factors and Directly observed treatment short course


Background: One of the important factors in control of tuberculosis is non-compliance has role in multi-drug resistant tuberculosis, poor treatment outcome and cause increased morbidity and mortality of tuberculosis.

Objective: This study explores the contribution of non-pharmacological factors in non-compliance of directly observed treatment short course among tuberculosis patients.

Methodology: The Cross sectional prospective study was interviewed by using set of questionnaire with enrolled patients of TB at DOTS centre of LRS Institute of Tuberculosis and Respiratory disease New Delhi, India. The Patients who discontinue and interrupted treatment for more than 2 months were categorized as noncompliance cases.

Results: Five hundred sixty six patients TB patients enrolled during the study out of which forty non-compliance cases we observed. various factors and their contribution in noncompliance, the nuclear family have contribution 40 %, living life style of three member family in one room set contribute 42.5% role in non-compliance and types of patients who was new found 35% contribution in non-compliance. Beside these 10% of non-compliance TB patient have positive influence to tuberculosis treatment, as family and social factors have 70 % negative influence in non-compliance as well as psychological and their positive influence to non-compliance in tuberculosis treatment were only 40%.

Conclusion: Various factors contribute in non-compliance of tuberculosis treatment therefore more attention should be paid to psychological aspect in order to behavioral and life style modification during tuberculosis treatments.


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Global Report for Research on Infectious Diseases of Poverty. World Health Organization on behalf of the Special Programme for Research and Training in Tropical Diseases. 2012.

World Health Organization . Global health risks: mortality and burden of disease attributable to selected major risks. 2009.

Revelas A. Tuberculosis: a disease that is alive and kicking. Southern African Journal of Epidemiology and Infection.2013; 28-3.

Salaam-Blyther T.Tuberculosis: International Efforts and Issues for Congress. CRS Report for congress. 2008.

Global Tuberculosis Report. World health organization. 2012

Glaziou P, Sismanidis C, Floyd K, Raviglione M. Global Epidemiology of Tuberculosis. Cold Spring Harb Perspect Med. 2015; 5-a017798.

Kaufmann SH. Is the development of a new tuberculosis vaccine possible?. Nature Medicine. 2000; 6 (9): 955-960

Dietrich J, Doherty TM. Interaction of Mycobacterium tuberculosis with the host:consequences for vaccine development. acta pathologica, microbiologica, et immunologica Scandinavica. 2009; 117: 440–457.

Reyad M, Bokhari SM, Ansari P, Shahjahan DM, Hosen J, Fami IJ. Present scenario of drug adherence on tuberculosis medicines in bangladeshi patients: a comprehensive review. World Journal of Pharmaceutical Research. 2015; 4 (6): 2352-81.

Jimmy B, Jose J. Patient Medication Adherence: Measures in Daily Practice. Oman Medical Journal. 2011;26 (3 ): 155-9.

Johnson R, Streicher EM, Louw GE, Warren RM, Helden PD, Victor TC. Drug Resistance in Mycobacte-rium tuberculosis. Mol. Biol. 2009; 8: 97–112.

Laxminarayan R, Bhutta Z, Duse A, Jenkins P, Thomas O'Brien T, et al. Drug Resistance. Disease Control Priorities in Developing Countries. 2nd edition. 2006; 1031-52.

World Tuberculosis Day 2009: Partnership for TB care. Indian J Med Res. 2009; 215-18.

Martin LR, Williams SL, Haskard KB, DiMatteo MR. The challenge of patient adherence. Therapeutics and Clinical Risk Management 2005:1(3) 189 –99.

Managing Tuberculosis Patients and Improving Adherence. Self-Study Modules on Tuberculosis. CDC. 2009.

Selgelid MJ. Ethics, Tuberculosis and Globalization. Public Health Ethics. 2008; 1(1); 10-20.

Marra CA, Marra F, Cox VC, Palepu A, Fitzgerald JM. Factors influencing quality of life in patients with active tuberculosis. Health and Quality of Life Outcomes 2004; 2:58.

Marra CA, Marra F, Colley L, Moadebi S, Elwood K, Fitzgerald JM. Health-Related Quality of Life Trajec-tories among Adults with Tuberculosis. CHEST. 2008; 133; 2-8.

Orr P. Adherence to tuberculosis care in Canadian Aboriginal populations Part 1: definition, measurement, responsibility, barriers. International Journal of Circumpolar Health. 2011; 70:2

Niazi AD, Al-Delaimi AM. Impact of community participation on treatment outcomes and compliance of DOTS patients in Iraq. East Mediterr Health J. 2003; 9(4):709-17.

Dolma KG, Adhikari L, Mohapatra PK, Mahanta J. Determinants for the retreatment groups of pulmonary tuberculosis patients in DOTS Programme in Sikkim India. Indian J. Tuberc. 2011; 58; 178-88.

Ducati RG, Ruffino-Netto A, Basso LA, Santos DS. The resumption of consumption. A review on tuberculosis. Rio de Janeiro. 2006; 101(7): 697-714

Jaggarajamma K, Sudha G, Chandrasekaran V, Nirupa C, Thomas A, Santha T, Muniyandi M. Reasons for Non-Compliance among patients treated under Revised National Tuberculosis Control Programme (RNTCP), Tiruvallur District, South India. Indian J Tuberc. 2007; 54,130-35.


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How to Cite

Md Salahuddin Ansari, Abdulmohsen H. AlRohaimi, Khalid U Khayyam, Manju Sharma, and Md Sarfaraz Alam. “CONTRIBUTION OF NON-PHARMACOLOGICAL FACTORS IN NON-COMPLIANCE OF DOTS AMONGST TUBERCULOSIS PATIENTS”. International Journal of Pharmaceutics and Drug Analysis, vol. 4, no. 10, Oct. 2016, pp. 452-9,



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