FORMULATION AND EVALUATION OF FLOATING MATRIX TABLET OF LEVOFLOXACIN HEMIHYDRATE
Keywords:Gastro retentive, Floating matrix tablet, Levofloxacin hemihydrate, Eudragit RS 100, In-vitro buoyancy, Non-Fickian
The objective of the present work was to develop Gastro retentive dosage forms which would remain in the stomach and upper part or GIT for a prolonged period of time thereby maximizing the drug release at desired site within the time before GRDFs left the stomach and upper part of the GIT, has provoked a great deal of increased interest in the formulation of such drug as Floating drug delivery systems. Levofloxacin, (BCS class I) is a fluoro-quinolone anti-bacterial agent. The rationale for the formulation of floating matrix tablet are acidic solubility of levofloxacin, residence of Halicobactor pylori mainly in sub region of stomach and the overdosing associated adverse effect due to continuous intake of drug in acute infection. Floating tablet of levofloxacin hemihydrate was prepared by wet granulation method using different hydrophilic and hydrophobic polymers like guar gum, hydroxyl propyl methyl cellulose and Eudragit RS 100, sodium alginate, xanthan gum. Sodium bicarbonate and citric acid was used as gas generating agents. The FTIR spectra of the levofloxacin hemihydrate and Eudragit RS 100, guar gum, hydroxyl propyl methyl cellulose, sodium alginate, and xanthan gum alone and in combination show the compatibility of the drug and excipients. Formulations were optimized on the basis of in- vitro drug release in 0.1N HCL. It was found that the levofloxacin hemihydrate - Eudragit RS 100 (1:1) has given the best dissolution results. The optimized formulation evaluated for physical parameters such as weight uniformity, hardness, friability, drug content, in-vitro buoyancy and swelling index. The release mechanism of levofloxacin hemihydrate from the tablets was non-Fickian.
Ratnaparkhi, M. P. & Gupta, J. P. Sustained Release Oral Drug Delivery System - An Overview. International Journal of Pharma Research & Review. 2013; 2(3): 11-21.
Patel, K. K., Patel, M.S., Bhatt, N. M., et al. An Overview: Extended Release Matrix Technology. International Journal of Pharmaceutical and Chemical Sciences. 2012; 1(2): 828-843.
Dash, T.R. & Verma, P. Matrix Tablets: An Approach towards Oral Extended Release Drug Delivery. International Journal of Pharma Researh & Review. (2013) 2(2): 12-24.
Kumar, M., Jha, S., Singh, S., et al. Floating Drug Delivery System: A Innovative Approach. Journal of Drug Delivery & Therapeutics. 2012; 2(6): 117-123.
Shaha, S.H., Patel, J.K., Shudu, P., Patel, N.V. An overview of a Gastro-Retentive Floating Drug Delivery System. Asian Journal of Pharmaceutical Sciences. 2009; 4(1): pp65-80.
Mayavanshi, A.V. & Gajjar, S.S. Floating drug delivery systems to increase gastric retention of drugs: A Review. Research Journal of Pharm. and Tech. 2008; 1(4): 345-348.
Shahwal, V.K., Dubey, B.K., Bhoumick, M. Preformulation study of Levofloxacin. International Journal of Advances in Pharmaceutics. 2012; 1 (1):1-8.
Reddy, D., Kishore, S., Krishna, T., Rao, P. Preparation and Evaluation of Levofloxacin Hemihydrates Floating Tablets. Journal of Drug Delivery Research. 2013; 2(1): 1-15.
Doodipala, N., Palem, C.R., Rao, Y.M. Pharmaceutical Development and Clinical Pharmacokinetic Evaluation of Gastro-retentive Floating Matrix Tablets of Levofloxacin. International Journal of Pharmaceutical Sciences and Nanotechnology. 2011; 4(3): 1463-1469.
Shah, S.H., Patel, J.K., Patel, N.V. Formulation and evaluation of effervescent floating tablet of Levofloxacin against H. pylori infection. Pelagia Research Library Der Pharmacia Sinica. 2010; 1 (3): 232-244.
Arunachalam. A. Rathinaraj, B.S., Rajveer, Ch., et al. Design and Evaluation of Levofloxacin Hemihydrate Floating Tablets. International Journal of Applied Biology and Pharmaceutical Technology. 2010; 1(2): 260-268.
Thakkar V.T., Shah P.A., Soni T.G, et al. Fabrication and Evaluation of Levofloxacin Hemihydrate Floating Tablet. Research in Pharmaceutical Sciences. 2008; 3(2): 1-8.
Sahu H., Jain V., Upmanyu N, et al. Formulation and Evaluation of Effervescent Floating Tablet of Levofloxacin. Scholars Research Library Der Pharmacia Lettre. 2011; 3 (6):272-279.
Bhalerao S. D., and Mahaparale P. R. Development and Evaluation of floating drug Delivery System of Levofloxacin. Novel Science International Journal of Pharmaceutical Science. 2012; 1(8):585-588.
Nagendrakumar D., Shirsand S.B., Para M.S, et al. Design and optimization of Levo?oxacin Gastroretentive tablets. RUGHS Journal of Pharmaceutical Sciences. 2012; 2(1): 38-44.
United States Pharmacopoeia National Formulary. (2007) US Pharmacopoeia The Standard of Quality, US 30 NF 25.1246.
Jain N.K. (2004) Progress in Controlled and Novel Drug Delivery Systems. 1st Ed. CBS Publishers & Distridutors. New Delhi. 90-93.
Lachman L., Lieberman H.A., Kanig J.L. The Theory and Practice of Industrial Pharmacy, 3rd Edition, Published by Varghese Publishing house, Bombay: 293-303, (1991)
Aulton, M E. Pharmaceutics- The Science of Dosage Form Design, 2 Edition, Harcourt Publishers Limited and Elsevier Science Limited, 293-295, (2002)
Sarkar B.K., Jain D.A. & Sharma V. Formulation & Evaluation of Flurbiprofen Matrix tablet for colon targeting. International Journal of Pharmaceutical & Chemical Sciences. 2012; 1(2): 477-483.
United States Pharmacopoeia 28 NF 23 (2005) The Official Compendia of Standards. Published by United States Pharmacopeial Convention, Inc. Rockville, MD, Asian Edition, Printed in Canada by Webcome Ltd. Toronto, Ontorio
Dash S., Murthy P.N., Nath Lilakanta, et al. Kinetic Modeling on Drug Release From Controlled Drug Delivery Systems. Acta Poloniae Pharmaceutica ñ Drug Research. 2010; 67(3): 217-223.
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