THE STUDY OF HYPOTENSIVE EFFECTS OF AQUEOUS LEAVE EXTRACT OF VERNONIA AMYGDALINA ON NORMOTENSIVE CATS
Keywords:Hypotensive, Blood pressure, Vernonia amygdalina, Normotensive, Hypertension, Effects, Aqueous extract, Cats
The hypotensive effects of aqueous leave extract of Vernonia amygdalina were evaluated on normotensive cats. The cats
used for this experiment were injected with the aqueous leave extract of Vernonia amygdalina at doses of 1mg/ml,
10mg/ml and 100mg/ml through a canula inserted in the femoral artery. Acetylcholine has a relaxing effect on the blood pressure. Atropine, a receptor blocker was then administered along with the standard drug and the leave extract in order
to determine the potency of its blocking effect on the leave extract and standard drug. The leave extract of Vernonia amygdalina produced a significant decrease in blood pressure. The 1mg/ml of the leave extract exhibited more effective response; however the standard drug Acetylcholine showed a greater potency than the extract. The blood pressure reducing effects of both drug and extract was inhibited by Atropine. Based on our observations, we therefore conclude that the aqueous leave extract of Vernonia amygdalina produced significant reduction in cat blood pressure and could be use in the management of hypertension.
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