• Shaina Kalsi Department of Pharmacology, CT institute of Pharmaceutical Sciences, Shahpur, Jalandhar.
  • Dr. Santosh Kumar Verma Department of Pharmacology, CT institute of Pharmaceutical Sciences, Shahpur, Jalandhar
  • Neha Department of Pharmacology, CT institute of Pharmaceutical Sciences, Shahpur, Jalandhar
  • Arshvir Kaur Department of Pharmacology, CT institute of Pharmaceutical Sciences, Shahpur, Jalandhar
  • Narinder Singh Department of Pharmaceutics, CT institute of Pharmaceutical Sciences, Shahpur, Jalandhar.


Liquorice, Active Constituents, Pharmacological Activities, Patent


Liquorice is a plant of old cause ever. Liquorice extracts and its principle segment, glycyrrhizin, have broad use in foods, tobacco and in both herbal medicine and traditional. Subsequently, there is a high level utilization of Liquorice and glycyrrhizin affirmed for use in foods and medicines of different ailments, for example, including against ulcer, anti-inflammatory, anti-viral and hepatoprotective reactions. Traditional applications crosswise over various societies incorporate as both a demulcent and a mitigating agent to calm respiratory or gastrointestinal (GI) manifestations. Modern botanical uses of the herb include the treatment of gastric ulcers, bronchitis, hack, and dyspepsia. While Liquorice is imperative in these and numerous other home applications, it accompanies a slight yet quantifiable danger of symptoms when utilized overall.


Download data is not yet available.


Glycyrrhiza glabra Linn monograph, Alternative Medicine Review, 2005; 10(3): 230- 237.

Olukoga A, Donaldson D. Historical perspectives on health. The history of liquorice: the plant, its extract, cultivation, and commercialization and etymology of the Royal Society of Health. 1998; 118:300-304.

Rastogi RP, Mehrotra BN. Compendium of Indian Medicinal Plants published by Central Drug Research Institute, Lucknow and National Institute of Sciences Communication and Information Resources, New Delhi.1990-1994; 6: 395-398.

Borst JG, Blomhert G, Molhuysen JA, Gerbrandy J, Turner KP, de Vries LA. Excretion of water and electrolytes during a 24-hour period and under influence of licorice extract. Acta Clin Belg. 1950; 5(4):405-409.

Yang L, Liu Y. L, Lin S. The determination of flavonoid in 6 kinds of licorice root by HPLC.Acta Pharmaceutics Sinica. 1990; 25:840?848.

Bradley, P.R. British Herbal Compendium, Volume 1, BHMA, Bournemouth. 1992

Hoffmann, D. The New Holistic Herbal, Second Edition, Element, Shaftesbury. 1990


Isbrucker RA, Burdock GA, Regulatory Toxicology and Pharmacology, 2006; 46: 167-192.

Crance JM, Biziagos E, Passagot J. Inhibition of hepatitis A virus replication in vitro by antiviral compounds. J Med Virol.1990; 31:155?160.

Van Rossum TG, Vulto AG, Hop WC. Intravenous glycyrrhizin for the treatment of chronic hepatitis C: a double-blind, randomized, placebo?controlled phase I/II trial. J Gastroenterol Hepatol.1999;14:1093?1099.

Baba M, Shigeta S. Antiviral activity of glycyrrhizin against Varicella?zoster virus in vitro. Antiviral Res.1987; 7:99?107.

Armanini D, Karbowiak I, Funder JW. Affinity of liquorice derivatives for mineralocorticoid and glucocorticoid receptors. Clin Endocrinol (Oxf) 1983; 19:609?612.

Dirsch V, Faculty of Life Sciences, Universitat Wien, 2006

Setzer N, Natural Products Drug Discovery, 1999

Olukoga A, Donaldson D. Historical perspectives on health. The history of liquorice: the plant, its extract, cultivation, and commercialization and etymology. J R Soc Health 1998; 118:300?304.

Bisset; N.G, Wichtl M. Herbal Drugs and Phytopharmaceuticals, German edition Stuttgart: Medpharm,1996

Gupta VK, Fatima A, Faridi U, Negi AS, Shanker K, Kumar JK, Rahuja N, Luqman S, Sisodia BS, Saikia D, Darokar MP, Khanuja SP.Antimicrobial potential of Glycyrrhiza glabra Linn roots, Journal of Ethno pharmacology. 2008; 116(2): 377-80.

Manoj M. Nitalikar, Kailas C, Munde, Balaji V, Dhore, Sajid N, Shikalgar. Antibacterial Activities of Glycyrrhiza glabra Root Extract. International Journal of Pharm Tech Research.2010;2(1):899-901.

Wang GS, Han ZW. The protective action of glycyrrhiza flavonoids against carbon tetrachloride hepatotoxicity in mice.Yao Xue Xue Bao.993; 28(8): 572?6.

Herold A, Cremer L, Calugaru A, Tamas V, Ionescu F, Manea S, Szegli G,. Antioxidant properties of some hydroalco-holic plant extracts with anti-inflammatory activity. Roumanian Archives of Microbiology and Immunology. 2003; 62(3-4): 217-27.

Murray WJ.Herbal Medications for Gastrointestinal Problems. In: Miller LG, Murray WJ (editors). Herbal Medicinal: A Clinician s Guide. Pharmaceutical Products Press, New York. 1998; 79-93.

Mills SY, Bone K. Principles and Practice of Phototherapy: Modern Herbal Medicine. Churchill Livingstone, London, 2000.

Anderson DM, Smith WG. The antitussive activity of glycyrrhetinic acid and its derivatives. J.Pharm.Pharmacol.1961; 13:396?404.

Da Nagao Y, Sata M, Suzuki H,. Effectiveness of glycyrrhizin for oral lichen planus in patients with chronic HCV infection. J Gastroenterol 1996; 31:691?695.

Ambawade V, Kasture VS Kasture SB. Anticonvulsant Activity of roots and rhizomes of Glycyrrhiza glabra Linn. Indian Journal of Pharmacology.2002; 34: 251-255.

Chopra D, Simon D. The Chopra Centre Herbal Handbook: Forty Natural Prescriptions for Perfect Health. Three Rivers Press, New York, 2000.

Yamaguchi T Watanabe T. Effects of triterpenes on the mutagenicities of various mutagens toward Salmonella. Journal of Agricultural and Biological Chemistry.1984; 48: 3137-3139.

Dhingra D, Parle M, Kulkarni SK, Memory enhancing activity of Glycyrrhiza glabra Linn in mice, J ethno pharmacology, 2004; 91(2-3): 361-365.

Hiroshi Hojoa, Jun Satob Antifungal Activity of Licorice (Glycyrrhiza glabra) and Potential Applications in Beverage Foods Food Ingredients J. Japan No. 203 (2002).

Kalkstein Samuel. Process of preparing licorice root extract. US 3131175, assigned to Chem & Phosphates Ltd ; 1964.

Antonino Coco Biagio, Pietro Condorelli. Process for extracting the juice from liquorice. US 1849569 A, assigned to Antonino Coco Biagio, Pietro Condorelli; 1932.

Harold A. Hartung. Glycyrrhizin-free fractions from licorice root and process for obtaining such fractions. US 4163067, assigned to Macandrews And Forbes Company; 1979.

Chantal Bergeron, Stefan Gafner. Supercritical CO2 liquorice extract and products made there from. US 8236360 B2, assigned to Tom's Of Maine, Inc.; 2012.


208 Views | 127 Downloads

How to Cite

Shaina Kalsi, Dr. Santosh Kumar Verma, Neha, Arshvir Kaur, and Narinder Singh. “A REVIEW ON GLYCYRRHIZA GLABRA (LIQUORICE) AND ITS PHARMACOLOGICAL ACTIVITIES”. International Journal of Pharmaceutics and Drug Analysis, vol. 4, no. 5, May 2016, pp. 234-9, https://ijpda.com/index.php/journal/article/view/219.



Review Articles
Share |