A poles apart applications of somatostatin hormone

Authors

  • Rasika walunj Department of pharmaceutics, modern college of pharmacy (for ladies), Moshi, Pune, India
  • Om Bagade Department of pharmaceutics, modern college of pharmacy (for ladies), Moshi, Pune, India

Keywords:

Somatostain, Receptors, Analogs, Inhibition, Endocrine system

Abstract

Somatostatin is a 14 amino acid peptide that inhibits pancreatic exocrine and endocrine secretion. Initially isolated from the ovine hypothalamus, it is widely distributed throughout the gastrointestinal tract where it may act as a hormone, local chemical messenger, or neurotransmitter to elicit many physiological actions includeing modulation of neurotransmission, inhibition of endocrine secretion, inhibition of cell proliferation and smooth muscles contractility. Its clinical applications have been limited by its very short half-life, necessitating continuous intravenous infusion. Synthethic somatostatin analogs have longer half-lives than somatostatin, but have similar activities. The recent advances in this field will be brie?y summarized.

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Published

2016-03-26
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Rasika walunj, and Om Bagade. “A Poles Apart Applications of Somatostatin Hormone”. International Journal of Pharmaceutics and Drug Analysis, vol. 4, no. 3, Mar. 2016, pp. 126-39, https://ijpda.com/index.php/journal/article/view/211.

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