FORMULATION AND EVALUATION OF ETHOSOME FOR ECONAZOLE NITRATE AS A MODEL DRUG TO EN-HANCED TRANSDERMAL DELIVERY
Keywords:Ethosome, Econazole nitrate, transdermal delivery and dispersion method
Ethosome are soft malleable vesicle tailored for enhanced delivery of active agent. The application of medicines to the skin surface serves the purpose of delivering the active ingredient into the skin (dermal delivery) or through the skin and into the systemic blood circulation (transdermal delivery). The objective of present study was to prepare and evaluate the ethosomes of Econazole nitrate as a model drug to increase its depth of penetration to through skin for enhanced dermal/transdermal delivery. Novel penetration enhancer, ethosomes of Econazole nitrate were prepared successfully using mechanical- dispersion method for prolonged as well as controlled release. The prepared formulation were characterized for various evolutionary parameters like vesicle size, entrapment efficiency, vesicle elasticity, in-vitro drug deposition study and rate of transdermal flux across stratum corneum and prepared formulation were also characterized for in-vitro release study by using cellophane membrane. From in-vitro drug release studies and the biological activity study suggests that the ethosomal formulation shows good release rate in agar plate model that indicate that ethosomes would probably shows good release in humans.
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