DESIGN, DEVELOPMENT AND VALIDATION OF ANA-LYTICAL METHOD FOR AMLODIPINE-COPPER COMPLEX USING UV –VIS SPECTROPHOTOMETRY

Authors

  • PRASHANT L PINGALE Assistant Professor, Department of Pharmaceutics, GES’s Sir Dr. M.S. Gosavi College of Pharmaceutical Education & Research, Nashik, Maharashtra, India 422005.
  • GARIMA KUMAR Assistant Professor, Department of Pharmaceutics, GES’s Sir Dr. M.S. Gosavi College of Pharmaceutical Education & Research, Nashik, Maharashtra, India 422005.

Keywords:

Amlodipine, UV Vis- spectrophotometry, Photodegradation, Complexation

Abstract

To develop spectrophotometric method for the determination of amlodipine besylate by forming complex with copper ion. Secondly, to develop a method that would be an easy, economical and accurate method as compared to other processes. The materials used were of laboratory grade and the method used was complexation with the potent API (Amlodipine besylate). The results showed that the complex was developed by using acetate buffer pH4.7 in a fixed ratio (1:1.25) with copper sulphate. Thus, it was concluded that the complex formation with copper reduced the photolytic degradation as observed in the bulk analysis of amlodipine by using UV Vis spectrophotometry. The developed method was found to be simple, accurate and economical for routine analysis.

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Published

2016-01-15
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PRASHANT L PINGALE, and GARIMA KUMAR. “DESIGN, DEVELOPMENT AND VALIDATION OF ANA-LYTICAL METHOD FOR AMLODIPINE-COPPER COMPLEX USING UV –VIS SPECTROPHOTOMETRY”. International Journal of Pharmaceutics and Drug Analysis, vol. 4, no. 1, Jan. 2016, pp. 1-11, https://ijpda.com/index.php/journal/article/view/190.

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