Recent Advancements in Tablet Technology: The need of hour


  • Ankit Verma Department of Pharmaceutics, CT institute of pharmaceutical sciences, Sahapur, Jalandhar, India.
  • Surya Prakash Gautam Department of Pharmaceutics, CT institute of pharmaceutical sciences, Sahapur, Jalandhar, India.
  • Tapsya Gautam Department of Pharmaceutics, CT institute of pharmaceutical sciences, Sahapur, Jalandhar, India.
  • Sukhbir Kaur Department of Pharmaceutics, CT institute of pharmaceutical sciences, Sahapur, Jalandhar, India.
  • Kapil Kanwar Department of Pharmaceutics, CT institute of pharmaceutical sciences, Sahapur, Jalandhar, India.


Tablet in Tablet, Layered Tablets, Caplets


In this era of innovation and advancement in drug delivery for better clinical effects conventional dosages form have still a strong grip and most popular in all kinds of medicinal preparation intended for oral use. To satisfy the need of growing market tablets dosages form have incorporated automation in manufacturing and some advanced tablet types. Modified release tablet formulations including, layered tablets such as In-lay tablet, Bi-layered tablet, Medicated chewing gum, Tablet tarts, Pastilles, Lollipop, Tablet inserts, Clinicaps, Caplets, Child ecstasy tablet and Tablet in tablet are new entries in pharmaceutical market. This review highlights the current advancements and patents in tablet technology.


Download data is not yet available.


Gopinath C, BinduHV, Nischala M. An Overview on Bi-layered Tablet Technology. Journal of global trends in pharmaceutical sciences.2013; 4(2): 1077-1085.

Nilawar S, Wankhade V, Badnag D.An Emerging Trend on Bilayer Tablets. International Journal of Pharmacy and Pharmaceutical Science Research. 2013; 3(1): 15-21.

Mala1 D, Chudasama J, Narayan P, Singh RP. Formulation and evaluation of amoxycillin and potassium clavulanatebilayered tablets. International journal of pharmaceutical and chemical sciences. 2014; 3(1): 264-273.

Dey S, ChattopadhyayS,Mazumder B. Formulation and Evaluation of Fixed-Dose combination of Bilayer Gastroretentive Matrix Tablet Containing Atorvastatin as Fast-Release and Atenolol as Sustained-Release.BioMed Research International.2014; 12.

Reddy RK, Srinivas N.Formulation and evaluation of bilayered tablets of losartan potassium.Innovations in Pharmaceuticals and Pharmacotherapy. 2014; 2(1): 312-320.

Indhumathi D, Sheik MV, Priyadharshini N, Damodharan N.Formulation and evaluation of bilayer tablet of conven-tional release paracetamol and modified release diclofenac sodium.Indian journal of research in pharmacy and biotechnology. 2013; 676-678.

Ahmed NVH, Niharika G, Deepak P,Nazan S, Mohammed AS.Formulation Design, Characterisation And In Vitro Evaluation Of Bilayered Tablets Containing Telmisartan And Hydrochlorthizide. International Journal of Biopharmaceutics. 2013; 4(1): 1-9.

Udayakumar T, Vasudevan M. Novel Sustained Release SwellableBioadhesive Floating Gastroretentive Drug Delivery System of Bilayer Tablets Containing Rifampicin and Isoniazid. International Journal of Pharmaceutical Sciences Letters. 2012; 1: 21-24.

Bagyalakshmi J, Phani YK, Ravi TK. Bilayer tablet formulation of metformin hydrochloride and glipizide: a novel approach in the treatment of diabetes. International journal of pharmaceutical sciences review and research. 2011; 8(2): 209-214.

Remya PN, Damodharan N, Sulakshan KCV. Formulation and Evaluation of Bi-layered Tablets of Ibuprofen and Methocarbamol. International Journal of PharmTech Research. 2010; 2(2): 1250-1255.

Mujoriya RZ, Venkateshvarlu, Singh DC, Gupta VA, Bisen A, Bondre AB. Formulation Development and Evaluation of Metoprolol Succinate Er and Amlodipine Besilate Bilayer Tablet. Research J. Pharm. and Tech.2010; 3(4): 1-4.

Derle D, Joshi O, Pawar A, Patel J, Jagadale A. Formulation and evaluation of buccoadhesive bi-layer tablet of pro-pranolol hydrochloride. International Journal of pharmacy and pharmaceutical sciences. 2009; 1(1): 206-212.

Gerber M,Huang N,Koziara JM, Zhang F. Pharmaceutical compositions ofRanolazine and dronedarone. US 2015/0037410 A1.2015;1-15.

Nakatani M, Yokoyama K, Sawada T. Bilayer tablet comprising telmisartan and diuretic. US 8,637,078 B2.2014;1-14.

Cifter U, Turkyilmaz A, Uzer IM, Terkinli A, Oner L. Modified release pharmaceutical compositions of dexlansoprazole. US 8,741,345 B2. 2014;1-8.

Abebe A, Martin K, Patel MJ, Desai D, Timmins P. Bilayer tablet formulations. US 8,535,715 B2.2013; 1-48.

Rossignol FJ, Petersburg, Ayers M, Tampa. Controlled release pharmaceutical formulations of Nitazoxanide. US 8,524,278 B2. 2013; 1-18.

Plachetka JR, Kothapalli VM, Gilbert DL. Multilayer dosage forms containing NSAIDS and Triptans. US 7,332,183 B2.2008;1-20.

Mehta BP, Joshi MD. Bilayer tablets of oxcarbazepine. US 2006/0141037 A1.2006;1-9.

Eisenreich W. Bilayer tablet of telmisartan and amlodipine. US 2006/0110450 A1.2006; 1-9.

Patel AA, Guo M, Matharu AS. Bilayer tablet comprising an antihistamine and a decongestant. US 2005/0220877 A1.2005; 1-8.

Shila VD, Patil1 EA, Bari MM, Barhate SD. A Review on Novel Approach – Bilayer Tablet Technology. International Journal of Pharmaceutical Sciences Review and Research.2013; 21(1): 46-52.

Keerthi ML, Kiran RS,Rao VUM, Sannapu A, Dutt AG, Krishna KS. Pharmaceutical Mini-Tablets, its Advantages, Formulation Possibilities and General Evaluation Aspects: A Review. International Journal of Pharmaceutical Sciences Review and Research.2014; 28(1): 214-221.

Ranjith K, Mahalaxmi R. Pharmaceutical Mini Tablets. International Journal of PharmTech Research. 2015; 7(3): 507-515.

Mounika A, Sirisha B, Rao VUM.Pharmaceutical mini tablets, its advantages and different enteric coating proc-esses.World journal of pharmacy and pharmaceutical sciences.2015; 4(8): 523-541.

Daniel KD,Hutchins BM,Elkins CL, Lee H. Solid Drug Tablets For Implantable Drug Delivery Devices. US 2013/0129824 A1.2013;1-8.

Arroyo HS, Rizo MJM, Castilla T. Pharmaceutical mini tablets for sustained release of flecainide acetate. EP2533766 A2. 2012; 1-10.

Bhattacharya S, Kshirsagar R,Joshi M,Pandita S. Extended Release Formulation Of Venlafaxine Hydrochloride. US 7,807,195 B2.2010;1-12.

Strumor MA, Hartman SJ. Healthful Dissolvable Oral Tablets, And Mini-Bars. US006149939A.2000;1-8.

Clancy MJA,Cumming KL. Cisapride Mini-Tablet Formulations. US006110494A. 2000; 1-4.

Umasankar K, Reddy PJ, Prabhakaran V.Fast dissolving tablet – review article. World Journal of Pharmaceutical Research.2014; 3(6): 424-437.

Singh CL, Rajput N, Monga MG. A review on fast dissolving tablets (FDTs). World Journal of Pharmaceutical Sciences. 2014; 2(11): 1572-1581.

Ritika S, Meenu R, Pawan P, Saurabh S. Fast Dissolving Drug Delivery System- A Review.Internationalresearch journal of pharmacy.2011; 2(11): 21-29.

kumar S, Garg SKR.Fast dissolving tablets (FDTS): current status, new market opportunities, recent advances in manufacturing technologies and future prospects. International journal of pharmacy and pharmaceutical sciences .2014; 6(7): 22-35.

Khirwadkar P, Dashora K. A Review: Fast Dissolving Drug Delivery System: Current Developments In Novel System Design And Technology. International Journal of Biomedical and Advance Research. 2012; 03(02): 82-99.

Abu-Izza KA, Li VH, LOOK JL, Parr GD, Schineller MK. Fast dissolving tablet. US 6,733,781 B2.2004; 1-18.

Kikuta JI, Makino T, Yamada M. Fast Dissolving Tablet and Its Production. EP 0553777 B1. 2002; 1-24.

Makino T, Yamada M, Kikuta JI. Fast dissolving tablet and its production. US 005501861 A. 1996; 1-20.

Prasad MSC, Babu BN, Ajay M, Raj SB, Audinarayana N, Reddy KB. Design and characterization of modified release isoniazid and salbutamol sulphate inlay tablet. International journal of pharmacy and pharmaceutical sciences.2011;3(4): 153-159.

Rajalakshmi R, Sireesha A, Lakshmi SM.Inlay Tablets – a novel approach. International journal of advanced pharmaceutics .2011; 1(1): 1-10.

Sahu M, Dinda SC. Formulation and development of modified release In-layered tablet. Journal of Pharmacy Research. 2010; 3(4): 794-798.


181 Views | 872 Downloads

How to Cite

Ankit Verma, Surya Prakash Gautam, Tapsya Gautam, Sukhbir Kaur, and Kapil Kanwar. “Recent Advancements in Tablet Technology: The Need of Hour”. International Journal of Pharmaceutics and Drug Analysis, vol. 3, no. 12, Dec. 2015, pp. 423-9,



Review Articles
Share |