STUDY OF BINDING PARAMETERS FOR INTERACTION BETWEEN NITROGLYCERINE AND SOME PROTEINS AND AMINO ACIDS.

Abstract

Nitroglycerin belongs to a class of drugs called nitrates. Nitroglycerin has been used to treat angina pectoris and heart failure for over 130 years. Nitroglycerin (NG), also known as nitroglycerine, trinitroglycerin, trinitroglycerine, or nitro, is more correctly known as glyceryltrinitrate or more formally: 1, 2, 3-trinitroxypropane. It is a heavy, colorless, oily, explosive liquid most commonly produced by treating glycerol with white fuming nitric acid under conditions appropriate to the formation of the nitric acid ester. Nitroglycerine metabolises to Nitric oxide in vascular smooth muscle cells. Nitroglycerine is used to make nitric oxide a compound in the body that relaxes blood vessels. In the present study we proposed to observe the effect of this nitroglycerine with some amino acids, proteins and carbohydrates in both Ultraviolet and visible region (with addition of colour developing reagents). Effect on spectra is studied in terms of binding interaction like the binding sites and binding association constants. This Study is found to provide interesting and significant data, which possibly may have correlation with biological effects by NO* on these amino acids and proteins.