EFFECTS OF CIGARETTE SMOKINGON OXIDATIVE STRESS AND SERUM MINERAL CONCENTRATIONS IN MALE SMOKERS OF KURNOOL DISTRICT
Keywords:Smoking, free radicals, , damage biomolecules, minerals , enzymes , cofactors, smokers
Smoking has been accepted as a risk factor for many chronic diseases, including cardiovascular diseases, respiratory
diseases, cancer, ulcers and osteoporosis. Tobacco smoke contains many oxidants and free radicals that can cause damage to
lipids, proteins, DNA, carbohydrates and other biomolecules The purpose of this study is to examine the effect of cigarette
smoking on serumoxidative damage, antioxidant status, and mineral concentrations in male subjects.Subjects were
randomly chosen from different work places in Kurnool city. Serum oxidative defense enzyme activities (CAT
andglutathione-s- transferase) and serum mineral (Zn, Cu and I) were evaluated. Serum zincand copper concentrations were
similar in the two groups. Thesefindings show that there is depletion in the non enzymatic antioxidant change dependingon
their co factor concentrations in tobacco smokers.
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