NEW APPROACH TO CHRONIC PAIN THERAPY WITH DRUGS TARGETING GLUTAMATE TRANSPORTER

Authors

  • Abhay Kumar Pandey PhD Scholar, Department of Physiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005

Keywords:

Glutamate, Pain Transporters

Abstract

Chronic visceral pain is a particularly difficult subcategory to manage. Glutamate is the most predominant excitatory
neurotransmitter and mediates many aspects of sensory function including acute and chronic pain. There is a growing
literature describing the efficacy of physiologically dominant glutamate transporter GLT-1 up-regulation in attenuating
chronic visceral and somatic nociception. Since glutamate is the major excitatory neurotransmitter released in the first
central synapse of the pain-transmitting afferent neurons, augmentation of GLT-1 activity, which reduces extracellular
levels of glutamate, may be an important target for pain management strategies. This review summarizes studies which
highlight findings that GLT-1 up-regulation by transgenic, pharmacologic and viral transfection approaches attenuates a
host of nociceptive responses emanating from visceral or somatic sources in animal models.

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Published

2014-02-11
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How to Cite

Abhay Kumar Pandey. “NEW APPROACH TO CHRONIC PAIN THERAPY WITH DRUGS TARGETING GLUTAMATE TRANSPORTER”. International Journal of Pharmaceutics and Drug Analysis, vol. 2, no. 2, Feb. 2014, pp. 70-73, https://ijpda.com/index.php/journal/article/view/15.

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Section

Review Articles
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