ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY: A NEW REVOLUTION IN LIQUID CHROMATOGRAPHY

Authors

  • Narwate B. M MES’s College of Pharmacy Sonai, Tal: Newasa ,Dist: Ahmednagar, Maharastra, India-414105
  • Ghule P. J MES’s College of Pharmacy Sonai, Tal: Newasa ,Dist: Ahmednagar, Maharastra, India-414105
  • Ghule A.V MES’s College of Pharmacy Sonai, Tal: Newasa ,Dist: Ahmednagar, Maharastra, India-414105
  • Darandale A.S MES’s College of Pharmacy Sonai, Tal: Newasa ,Dist: Ahmednagar, Maharastra, India-414105
  • Wagh J.G MES’s College of Pharmacy Sonai, Tal: Newasa ,Dist: Ahmednagar, Maharastra, India-414105

Keywords:

Ultra Performance Liquid Chromatography, UPLC Columns, High-performance liquid chromatography

Abstract

Ultra Performance Liquid Chromatography (UPLC) can be regarded as a new direction for liquid
chromatography. UPLC improves three areas of Liquid chromatography namely speed, resolution, and sensitivity of analysis by using particle size less than 2 ?m and the system is designed in a special way to withstand high system back-pressures. The separation on UPLC is performed under very high pressures (up to 100 MPa) but it has no negative influence on analytical column or other components of chromatographic system and also decrease of time and solvent consumption compare to HPLC. Now a day’s pharmaceutical industries as well as analytical laboratories are in search of new ways to reduce cost and time for analysis of
drugs and improve quality of their product. This review focus on basic principle, instrumentation and theory of UPLC. It also summarizes various pharmaceutical applications of this technique with examples.

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Published

2014-01-15
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How to Cite

Narwate B. M, N. B. M., G. P. J. Ghule P. J, G. A. Ghule A.V, D. A. Darandale A.S, and W. J. Wagh J.G. “ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY: A NEW REVOLUTION IN LIQUID CHROMATOGRAPHY”. International Journal of Pharmaceutics and Drug Analysis, vol. 2, no. 1, Jan. 2014, pp. 25-34, https://ijpda.com/index.php/journal/article/view/14.

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Review Articles
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