Influence of Dielectric constant on Protonation Equilibria of Glutathione in aqueous solutions of propylene glycol and acetonitrile
Keywords:Protonation constants, glutathione, propylene glycol, acetonitrile, MINIQUAD75
The protonation constants of glutathione have been determined pH metrically in 0.0-60.0% v/v propylene glycol- and
acetonitrile- water mixtures maintaining an ionic strength of 0.16 mol L-1 at 303.0 K. The protonation constants have been
calculated with the computer program MINIQUAD75 and the best fit chemical models are selected based on statistical
parameters. Linear variation of step-wise protonation constants with reciprocal of dielectric constant of the solvent mixture
has been attributed to the dominance of electrostatic forces.
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