DEVELOPMENT AND VALIDATION OF FIRST ORDER DERIVATIVE SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF MOXONIDINE IN BULK DRUG AND PHARMACEUTICAL DOSAGE FORM

Authors

  • M. P. YEOLE Smt. Kishoritai Bhoyar College of Pharmacy, Kamptee, Nagpur
  • M. J. UMEKAR Smt. Kishoritai Bhoyar College of Pharmacy, Kamptee, Nagpur

Keywords:

Moxonidine, First-order derivative, Method validation

Abstract

A rapid, precise, accurate and specific first-order derivative spectrophotometric method was developed for the
determination of moxonidine in pharmaceutical formulation. The technique was applied using 0.1M HCl as diluent. The
first-order derivative spectra were obtained and determination was made at 232 nm. The method showed good linearity in
the concentration range of 10-50 ?g/ml with correlation coefficient 0.999. The recovery ranged between 99.50 and 100.50
%. The proposed method will be suitable for the analysis of moxonidine in bulk and in marketed preparations. The results of
analysis have been validated statistically and by recovery studies.

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Published

2015-02-15
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How to Cite

M. P. YEOLE, and M. J. UMEKAR. “DEVELOPMENT AND VALIDATION OF FIRST ORDER DERIVATIVE SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF MOXONIDINE IN BULK DRUG AND PHARMACEUTICAL DOSAGE FORM”. International Journal of Pharmaceutics and Drug Analysis, vol. 3, no. 2, Feb. 2015, pp. 44-47, https://ijpda.com/index.php/journal/article/view/136.

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Research Articles
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