FORMULATION AND EVALUATION OF TASTE MASKED IMMEDIATE RELEASE TABLETS OF AZITHROMYCIN DIHYDRATE AND CHLOROQUINE PHOSPHAT USING ?-CYCLODEXTRIN
Keywords:Azithromycin, Chloroquine, Beta Cyclodextrin, ODT, Disintegration time; wetting time and taste masking
The main aim of the present study was to evaluate complexation as an approach for taste masking. For this purpose
Azithromycin and Chloroquine with property of bitter taste was selected as a model drug used for combination therapy.
Improvement in taste masking capability of cyclodextrin towards Azithromycine was evaluated by formulating a ternary
complex. In vitro dissolution study was carried out to see the effect of ternary complexation on drug release. Taste
perception study was carried out on human volunteers to evaluate the taste masking ability of ternary complexsation.
Complexation system showed effective taste masking as compared to binary complex and at the same time showed no
limiting effect on the drug release (D.E15min = 90%). The effective taste masking was attributed to the enhanced
complexsation of Azithromycin from the characterization studies. In conclusion, the study confirmed that complexsation
can be utilized as an alternative approach for effective taste masking.
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