POTENTIAL AMELIORATION OF MELIA AZEDARACHL AGAINST NICOTINE-INDUCED OXIDATIVE STRESS IN THE FEMALE RATS

Authors

  • K.Bhuvaneswari Department of siddha medicine, Faculty of Science, Tamil University Thanjavur, INDIA
  • V.Elango Department of siddha medicine, Faculty of Science, Tamil University Thanjavur, INDIA

Keywords:

Nicotine, ovary toxicity; Melia azedarach , ovarian oxidative stress

Abstract

The protective effect in female rat by oral administration of Melia azedarach (100 mg/kg bw /day) against ovarian and
uterine oxidative stress induced by subcutaneous injection of nicotine (4mg/kg bw/day), was studied. After 30 days,
nicotine treatment increased production of malondialdehyde in the nicotine-treated groupwhich was accompanied by
marked alterations in the levels of activities of superoxide dismutase, catalase, GSH, vitamin C and E.Compared to nicotine
alone, the combined treatment of nicotine with Melia azedarach significantly lowered the level of lipid peroxides and
enhanced the antioxidant status. The group of rats given Melia azedarach without exposure to nicotine exhibited no
significant changes in the above indices. Thus the results from this study showed that Melia azedarach exerted a protective
action against nicotine-induced oxidative stress and disturbance of ovarian functions in the rat.

Downloads

Download data is not yet available.

Published

2014-10-25
Statistics
5 Views | 17 Downloads
Citatons

How to Cite

K.Bhuvaneswari, and V.Elango. “POTENTIAL AMELIORATION OF MELIA AZEDARACHL AGAINST NICOTINE-INDUCED OXIDATIVE STRESS IN THE FEMALE RATS”. International Journal of Pharmaceutics and Drug Analysis, vol. 2, no. 10, Oct. 2014, pp. 805-10, https://ijpda.com/index.php/journal/article/view/117.

Issue

Section

Research Articles
Share |