ISSN : 2348 - 8948

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Volume : 2 Issue :5 Month : May (2014)
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Drug penetration enhancement via skin in transdermal drug delivery through stratum corneum- QSAR Modeling

VISHAL SHARMA, AJEET*, ARVIND KUMAR
The objective of this work was to develop a Quantitative Structure Activity Relationship (QSAR) model for understanding the effect of topological polar surface area, lipo-affinity index, fragment complexity and MLogP on the drug penetration power of penetration enhancers. For developing the model, Multiple Linear Regression (MLR) has been employed as an effective and efficient method and this model has been validated with statistical analysis such as fraction of variance, cross validation test, quality factor, standard deviation, and internal validation test. A regression based QSAR model has been developed with cross validation test q2 = 0.914 and fraction of variance r2 = 0.913, i.e. >90% predictive efficiency and all the statistical tests have validated this model.
 
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