ISSN : 2348 - 8948

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Volume : 7 Issue :3 Month : March (2019)
Page Numbers : 16-27

Effect Of Polymers On Metronidazole Anti-Amoebic Tablets On Colon Drug Delivery System.

Rajkumar, *Md. Majid Iqbal , Tukaram Tadmale, Rohit Saraswat
The aim of the present study is to compare the effect of polymers on colon targeted drug deli-very of Metronidazole compression coated tab-lets by using different polymer ratios of Chitosan and Pectin. Carbopol 934P coating is given for compression coated tablets which makes them able to release the drug at the pH of colonic fluid.Core Tablets of Metronidazole (400 mg) were prepared by using swellable and PH Dependent polymers like Chitosan and pectin in which PVP-K30 is used as Binder. Drug release profile was evaluated in simulated gastric fluid, intestinal fluid and simulated colonic fluid.The results of drug release studies performed according to the USP paddle method by using 0.1N Hcl for 2hrs, pH 7.4 phosphate buffer for 3 hrs and pH 6.8 phosphate buffer up to 24 hrs without using rat caecal content. Compression coated tablets con-taining chitosan as polymer released 95-99% of Metronidazole in simulated colonic fluid, whe-reas tablets containing pectin as polymer re-leased 94-99% of Metronidazole. The stability study for prepared tablets at 40°C/75% relative humidity for 6 weeks showed no significant change in physical appearance, Drug content uniformity and In vitro drug release pat-tern.From the result it can be concluded that Formulation F1 (Chitosan compression coated tablets) and Formulation F4 (Pectin compression coated tablets). Different polymers give different time interval but were suitable for colonic drug delivery as drug release is maximum while compared to other formulations.
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