ISSN : 2348 - 8948

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Volume : 6 Issue :8 Month : August (2018)
Page Numbers : 563-570

Development And Validation Of Liquid Chromatography Method For The Analysis Of Atazanavir In Pharmaceutical Dosage Forms

Sirsat Bhagwat, Arsul Vilas A*, Arsul Supriya V,
Atazanavir is an important antiretroviral drug. The objective of the current study was to devel-op a simple accurate, precise and rapid RP-HPLC method development and validation for determination of Atazanavir in tablet dosage form. Chromatographic separation was achieved on C18 Column with mobile phase Methanol: (0.1%) OPA (80:20) v/v with flow rate 0.7ml/min and UV detection was carried out on 250nm. Retention time of Atazanavir was found to be 4.302 & Linearity of proposed method was found to be in the range of 10-50 g/ml (r2=0.999). Method was statistically validated for its linearity, accuracy and precision. Both interday and intraday variation was found to be showing less %RSD (Relative Standard De-viation) value indicating high grade of preci-sion of method.
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