ISSN : 2348 - 8948

Current Issue

Volume : 6 Issue :11 Month : November (2018)
Page Numbers : 604-609

SYNTHESIS AND BIOLOGICAL EVALUATION OF ISOINDOLINE-1, 3-DIONE DERIVATIVES

Y. N. Ingale*, R. B. Ugale
A series of phthalimide derivatives were synthesized and evaluated for their analgesic and invitro anti-inflammatory activity. The target compounds were obtained by condensation of N-hydroxymethylphthalimide with the substituted triazole. The structures of the synthesized derivatives were confirmed by means of IR, 1H-NMR spectral data. The analgesic activity was determined by acetic acid induced writhings in mice and Invitro anti-inflammatory activity was evaluated using thermally induced protein denaturation technique. The results revealed the importance of the combination of triazole and phthalimide moieties as a promising analgesic and anti-inflammatory candidate.
 
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