ISSN : 2348 - 8948

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Volume : 6 Issue :8 Month : August (2018)
Page Numbers : 571-577

Fabrication and Characterization of Olopatadine Hydrochloride Loaded Bionanofibers as a Platform for Drug Delivery

Gitanjali Mehetre*, Vishal Pande
Bionanofibers drug delivery systems are able to improve therapeutic efficacy, reduce toxicity, and increase patient compliance by delivering drugs at controlled rate over a period of time to the site of action. Bionanofibers were individu-alized from Moringa oleifera gum by a chemical process and then mechanically separated into nanofibers using high- intensity ultrasoni-cation. The obtained bionanofibers were char-acterized on the basis of fiber length and diam-eter, morphology, entrapment efficiency and drug release behavior. FE-SEM images showed that the length of obtained bionanofibers is about 10m with 94nm in diameter. DSC data showed that the endothermic peak at about 253C for drug shifted to lower temperature in drug polymer blend. FTIR analysis shows no any significant interaction between drug and polymer. The in-vitro release study demonstrat-ed that there is a controlled release pattern of drug from bionanofibers.
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